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ISSN 0210-5187 (Electronic)

2013, Number 3

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Med Cutan Iber Lat Am 2013; 41 (3)

Folliculotropic mycosis fungoides. Analysis and outcomes of six cases

Hassan ML, Chaparro E, Waiman J, Moliné J, Moreno A, Endre J, Schroh RG, Corbella C, Ardaiz MT

Language: Spanish
References: 27
Page: 103-110
PDF size: 1131.97 Kb.


ABSTRACT

Folliculotropic mycosis fungoides is considered a rare variant of mycosis fungoides with a bad response to therapy, severe prognosis and shorter overlife. It includes cases with and without follicular mucinosis
Material and method: We report the retrospective analysis of clinical, histopathological, and immunohistochemical aspects, therapeutic responses and follow-up of six cases of folliculotropic mycosis fungoides studied in the Department of Dermatology from May 1994 to June 2010. Three of them exhibited follicular mucinosis in cutaneous biopsies and other three failed to reveil this finding.
Objective: To report our findings taking into account the years previous to diagnosis of MF (by re-examination of previous biopsies) in order to stimate the overlife.
Results and conclusions: In this population:
a) This variant of MF was very difficult to be diagnosed presenting unusual clinical lesions and unspecific microscopic patterns.
b) Previous stage of primary follicular mucinosis or unspecific microscopic findings could be quite long (2 to 11 years) until MF criteria were fulfilled.
c) Comedo-like lesions had a good response to bexarotene. Therapeutic responses of plaques and macules to phototherapy and systemic α2bIFN were partial and brief.
d) Allthoug the significance was limited by the small number of the sample ,these data seems to asses the worser prognosis to ten years of this variant if the years previous to confirmation of MF diagnosis were not considered: The overlife at 5 years was 75%(3/4), at 10 years 25% (1/4). Taking into account the period of undiagnosed MF the severity was atempered: overlife100% at 5 years (6/6), 60% at 10 years (4/6). Nobody experimented the spontaneous remission of the lesions during the time of observation.


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