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Academia Mexicana de Neurología, A.C.

2014, Number 4

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Rev Mex Neuroci 2014; 15 (4)

A multicentric study of non-motor symptoms assessment using the Movement Disorders Society- UnifiedParkinson’s Disease Rating Scale (MDS-UPDRS)

Rodríguez-Violante M, Cervantes-Arriaga A, Morales-Briceño H, Neri-Nani GA, Estrada-Bellmann I, Millán-Cepeda MR, López-Ruiz M, Calderón-Fajardo H, Llorens-Arenas R

Language: Spanish
References: 21
Page: 201-206
PDF size: 153.67 Kb.


ABSTRACT

Introduction: The nonmotor symptoms in Parkinson’s disease (PD) are considered of great importance due to their high frequency and their impact on the quality of life of patients. The Movement Disorder Socierty-Unified Parkinson’s Disease Rating Scale, or MDS- UPDRS, Part I assesses the main non-motor symptoms of the disease.
Objective: To describe and analyze the frequency of non-motor symptoms in a sample of PD patients from several centers of second and third in Mexico using the MDS-UPDRS.
Methods: We carried out a cross-sectional study with 423 patients diagnosed with Parkinson’s disease from five hospitals in Mexico. All patients were assessed using the Movement Disorder Society-Unified Parkinson’s Disease Rating Scales parts I to IV. The frequency of non-motor symptoms and their association with other clinical variables was analyzed.
Results: A total of 228 men and 195 women were included. The mean age of the subjects was 61.8 ± 12.5 years. The most frequent symptoms were cognitive impairment (71.9 %), pain (65.7 %), fatigue (61.7%) and depression (57.2%). The least frequent were psychosis (16.8 %) and dopaminergic dysregulation (5.4 %). There were significant differences in the depressive symptoms item, being the highest score in women (0.9 ± 1 vs. 1.2 ± 1.1, p = 0.012). The total score of the part I was higher in advanced stages of PD (p = 0.003).
Conclusions: The frequency of most of the non-motor based on Part I of the MDS- UPDRS symptoms are comparable to those reported in other studies in Mexican population.


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