2014, Number 2
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Rev Invest Clin 2014; 66 (2)
Quality of life in patients with bone tumors, a comparison between different treatments
González-Rodríguez E, Riveros A, Benjet C, González-Forteza C, León-Hernández SR, Rico-Martínez G
Language: Spanish
References: 31
Page: 121-128
PDF size: 153.83 Kb.
ABSTRACT
Introduction. Previously, amputation was the only treatment
option for patients with malignant bone tumors. Due
to technological, medical and surgical advances, the number
of survivors and years of survival has been increasing, and
thus, the interest in evaluating the impact of this disease on
quality of life.
Objective. To evaluate the health related
quality of life reported by patients with bone tumors undergoing
different treatments (no surgery/amputation/salvage).
Material and methods. Patients (n = 85) with bone tumors
over the age of 18, both sexes, from the Instituto Nacional de
Rehabilitación of Mexico City were included, divided into
three groups according to type of treatment. The study design
was cross-sectional, descriptive of a nonrandom sample.
Quality of life was assessed with the Inventory of Quality of
Life and Health (InCaViSa). Data were analyzed using descriptive
statistics, comparisons between patients with different
treatments were evaluated with multivariate analysis of
covariance and Sidak post hoc tests.
Results. Statistically
significant differences were detected in six of the twelve areas
of quality of life that are assessed by the scale: physical
functioning, isolation, body perception, treatment attitude
leisure time and daily life. Health related quality of life in
the study group is best for those patients who received amputation
compared with the other treatments, while patients
limb salvage procedures are those with greater impairment.
REFERENCES
Centro Nacional de Rehabilitación (Discapacidades, Prevención y Rehabilitación. Tumores Óseos). Disponible en: http:// www.ediscapacinet.gob.mx/images/stories/Liferay/discapacinet/ salud_rehabilitacion/PDF/tumores_oseos.pdf [Citado 1 junio 2013].
Sun YJ, Hu YJ, Jin D, Li JW, Yu B. Health-related Quality of Life After Treatment for Malignant Bone Tumors: A Followup Study in China. Asian Pac J of Cancer Prevention 2012; 13: 3099-102.
Bacci G, Ferrari S, Lari S, Mercuri M, Donati D, Longhi A, Forni C, et al. Osteosarcoma of the limb: amputation or limb salvage in patients treated by neoadjuvant chemotherapy. J Bone Joint Surg 2002; 84: 88-92.
Arndt V, Lacour B, Steliarova-Foucher E, Spix C, Znaor A, Pastore G, Stiller C, et al. Up-to-date monitoring of childhood cancer long-term survival in Europe: tumours of the sympathetic nervous system, retinoblastoma, renal and bone tumours, and soft tissue sarcomas. Ann Oncol 2007; 18: 1722-33.
Nagarajan R, Neglia J, Clohisy D, Robison L. Limb salvage and amputation in survivors of pediatric lower-extremity bone tumors: what are the long-term implications? J Clin Oncol 2002; 20: 4493-501.
Grimer R. Surgical options for children with osteosarcoma. Lancet Oncol 2005; 6: 85-92.
Wilkins R, Camozzi A, Gitelis S. Reconstruction options for pediatric bone tumors about the knee. J Knee Surg 2005; 18: 305-9.
Tang MH, Pan DJ, Castle DJ, Choong PF. A Systematic Review of the Recent Quality of Life Studies in Adult Extremity Sarcoma Survivors. Sarcoma 2012; doi: 10.1155/2012/171342.
Christensen A, Antoni M. Chronic Physical Disorders: Behavioral Medicine’s Perspective. Cap. 2: Social Psychological Aspects of Chronic Illness Oxford, UK: Blackwell Publishers Ltd; 2002, p. 25-46.
Bekkering WP, Vliet Vlieland TP, Fiocco M, Koopman HM, Schoones JW, Nelissen RG, Taminiau AH. Quality of life, functional ability and physical activity after different surgical interventions for bone cancer of the leg: A systematic review. Surg Oncol 2012; 21: e39-e47.
Bekkering WP, Vliet Vlieland TP, Koopman HM, Schaap GR, Schreuder HW, Beishuizen A, Tissing WJ, et al. Quality of life in young patients after bone tumor surgery around the knee joint and comparison with healthy controls. Pediatr Blood Cancer 2010; 54(5): 738-45.
Ahles T, Saykin A, Furstenberg C, Cole B, Mott L, Titus-Ernstoff L, Skalla K, et al. Quality of life of long-term survivors of breast cancer and lymphoma treated with standard-dose chemotherapy or local therapy. J Clin Oncol 2005; 23: 4399-405.
Eiser C, Molkenboer A, Stride C, Grimer R. Quality of life implications as a consequence of surgery: limb salvage, primary and secondary amputation. Sarcoma 2001; 5(4): 189-95.
Pogany L, Barr R, Shaw A, Speechley K, Barrera M, Maunsell E. Health status in survivors of cancer in childhood and adolescence. Qual Life Res 2006; 15: 143-57.
Eiser C. Assessment of health-related quality of life after bone cancer in young people: Easier said than done. Eur J Cancer 2009; 45: 1744-47.
Langenhoff B, Krabbe P, Wobbes T, Ruers T. Quality of life as an outcome measure in surgical oncology. Br J Surg 2001; 88: 643-52.
Eiser C, Jenney M, Measuring quality of life. Arch Dis Child 2007; 92: 348-50.
Urzúa M. Calidad de vida relacionada con la salud: Elementos conceptuales. Rev Med Chile 2010; 138: 358-65.
Marchese V, Spearing E, Callaway L, Rai S, Zhang L, Hinds P, Carlson C, Neel M, Rao B, Ginsberg J. Relationships among range of motion, functional mobility, and quality of life in children and adolescents after limb-sparing surgery for lowerextremity sarcoma. Pediatr Phys Ther 2006; 18: 238-44.
Aksnes L, Hall K, Jebsen N, Fosså S, Dahl A. Young survivors of malignant bone tumors in the extremities: a comparative study of quality of life, fatigue and mental distress. Support Care Cancer 2007; 15: 1087-96.
Reulen R, Winter D, Lancashire E, Zeegers M, Jenney M, Walters S, Jenkinson C, et al. Health-status of adult survivors of childhood cancer: a large-scale population based study from the British Childhood Cancer Survivor Study. Int J Cancer 2007; 121: 633-40.
Nagarajan R, Clohisy D, Neglia J, Yasui Y, Mitby P, Sklar C, Finklestein J, et al. Function and quality-of-life of survivors of pelvic and lower extremity osteosarcoma and Ewing’s sarcoma: the Childhood Cancer Survivor Study. Br J Cancer 2004; 91: 1858-65.
Refaat Y, Gunnoe J, Hornicek F, Mankin H. Comparison of quality of life after amputation or limb salvage. Clin Orthop Relat Res 2002; 397: 298-305.
Paul SJ. Long term quality-of-life outcomes in pediatric bone cancer: a systematic review. J Nurs Stud Res 2008; 1: 5-12.
McDougall J, Tsonis M. Quality of life in survivors of childhood cancer: a systematic review of the literature (2001–2008). Support Care Cancer 2009; 17: 1231-46.
Herrera A, Granados M. Manual de Oncología. Cap. 62. Sarcomas de tejidos blandos en el tronco y extremidades. 3a Ed. México: McGraw Hill; 2006. p. 637-50.
Rodríguez-Velázquez A, Alvarado-Aguilar S, Cuellar-Hübbe M, Villavicencio-Valencia V, Gómez-García, F. Nivel de ansiedad y depresión en pacientes amputados por sarcomas: estudio piloto. GAMO 2010; 9: 11-8.
Riveros A, Sánchez-Sosa JJ, Del Águila M. Manual Inventario de Calidad de Vida y Salud (InCaViSa). México: Manual Moderno; 2009.
Ottaviani G, Robert RS, Huh WW, Jaffe N. Functional, psychosocial and professional outcomes in long-term survivors of lower-extremity osteosarcomas: amputation versus limb salvage. Cancer Treat Res 2009; 152: 421-36.
Barr R, Wunder J. Bone and soft tissue sarcomas are often curable-But at what cost? Cancer 2009; 115: 4046-54.
Hewitt M, Weiner S, Simone J. Childhood Cancer Survivorship: Improving Care and Quality of Life. Disponible en: http:// www.nap.edu/catalog/10767.html [Citado en junio 2013].