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Instituto Nacional de Salud Pública

2014, Number 4

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salud publica mex 2014; 56 (4)

Some current challenges in research on air pollution and health

Samet JM

Language: English
References: 61
Page: 379-385
PDF size: 196.22 Kb.


ABSTRACT

This commentary addresses some of the diverse questions of current interest with regard to the health effects of air pollution, including exposure-response relationships, toxicity of inhaled particles and risks to health, multipollutant mixtures, traffic-related pollution, accountability research, and issues with susceptibility and vulnerability. It considers the challenges posed to researchers as they attempt to provide useful evidence for policy-makers relevant to these issues. This commentary accompanies papers giving the results from the ESCALA project, a multi-city study in Latin America that has an overall goal of providing policy-relevant results. While progress has been made in improving air quality, driven by epidemiological evidence that air pollution is adversely affecting public health, the research questions have become more subtle and challenging as levels of air pollution dropped. More research is still needed, but also novel methods and approaches to address these new questions.


REFERENCES

  1. Bell ML, Samet JM. Air pollution. In: Frumkin H, ed. Environmental health: from global to local. 2nd ed. San Francisco: Jossey-Bass, 2010:387-415.

  2. Brimblecombe P. Air pollution and health history. In: Holgate ST, Samet JM, Koren HS, Maynard RL, ed. Air Pollution and Health. San Diego: Academic Press, 1999:5-18.

  3. Brook RD, Rajagopalan S, Pope CA, 3rd, Brook JR, Bhatnagar A, Diez-Roux AV, et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 2010;121(21):2331-2378.

  4. Katsouyanni K, Samet JM, Anderson HR, Atkinson R, Le Tertre A, Medina S, et al. Air pollution and health: a European and North American approach (APHENA). Res Rep Health Eff Inst 2009(142):5-90.

  5. World Health Organization. Air Quality Guidelines: Global Update 2005-Particulate matter, ozone, nitrogen dioxide and sulfur dioxide. Copenhagen: World Health Organization, 2006.

  6. Health Effects Institute. Assessing Health Impact of Air Quality Regulations: Concepts and Methods for Accountability Research. HEI Communication 11. Boston, MA: HEI Accountability Working Group, 2003.

  7. Samet JM, Zeger S, Dominici F, Dockery D, Schwartz J. The National Morbidity, Mortality, and Air Pollution Study (NMMAPS). Part I. Methods and methodological issues. Cambridge, MA: Health Effects Institute, 2000.

  8. Zeger SL, Thomas D, Dominici F, Samet JM, Schwartz J, Dockery D, et al. Exposure measurement error in time-series studies of air pollution: concepts and consequences. Environ Health Perspect 2000;108(5):419-426.

  9. Berhane K, Gauderman WJ, Stram DO, Thomas DC. Statistical issues in studies of the long-term effects of air pollution: The Southern California Children’s Health Study. Statistical Science 2004;19(3):414-449.

  10. U.S. Environmental Protection Agency. The Clean Air Act Amendments of 1990 [accessed July 8, 2014]. Available from: http://www.epa.gov/air/caa.

  11. Bell ML, Peng RD, Dominici F. The exposure-response curve for ozone and risk of mortality and the adequacy of current ozone regulations. Environ Health Perspect 2006;114(4):532-536.

  12. Pope CA, 3rd, Burnett RT, Krewski D, Jerrett M, Shi Y, Calle EE, et al. Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship. Circulation 2009;120(11):941-948.

  13. Daniels M, Dominici F, Samet JM, Zeger SL. Estimating PM 10 -mortality dose-response curves and threshold levels: an analysis of daily time-series for the 20 largest US cities. Am J Epidemiol 2000;152:397-406.

  14. Miller KA, Siscovick DS, Sheppard L, Shepherd K, Sullivan JH, Anderson GL, et al. Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 2007;356(5):447-458.

  15. Beelen R, Raaschou-Nielsen O, Stafoggia M, Andersen ZJ, Weinmayr G, Hoffmann B, et al. Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project. Lancet 2014;383(9919):785-795.

  16. Brook RD, Cakmak S, Turner MC, Brook JR, Crouse DL, Peters PA, et al. Long-term fine particulate matter exposure and mortality from diabetes in Canada. Diabetes Care 2013;36(10):3313-3320.

  17. U.S. Environmental Protection Agency. National Ambient Air Quality Standards (NAAQS) 2009 [accessed July 8, 2014]. Available from: http://www.epa.gov/air/criteria.html.

  18. U.S. Environmental Protection Agency. Policy Assessment for the Review of the Particulate Matter National Ambient Air Quality Standards (Second external review draft). Report No.: EPA 452/P-10-007. Washington, DC: US Environmental Protection Agency, 2010.

  19. U.S. Environmental Protection Agency. Health Risk and Exposure Assessment for Ozone (Second External Review Draft). Research Triangle Park, NC: U.S. Environmental Protection Agency, 2014.

  20. Dominici F, Zeger S, Samet J. A measurement error correction model for time-series studies of air pollution and mortality. Biostatistics 2000;1(2):157-174.

  21. Schwartz J, Zanobetti A. Using meta-smoothing to estimate dose-response trends across multiple studies, with application to air pollution and daily death. Epidemiology 2000;11(6):666-672.

  22. Welty LJ, Peng RD, Zeger SL, Dominici F. Bayesian distributed lag models: estimating effects of particulate matter air pollution on daily mortality. Biometrics 2009;65(1):282-291.

  23. White RH, Cote I, Zeise L, Fox M, Dominici F, Burke TA, et al. State-of-the-science workshop report: Issues and approaches in low-dose-response extrapolation for environmental health risk assessment. Environ Health Perspect 2009;117:283-287.

  24. Bergen S, Sheppard L, Sampson PD, Kim SY, Richards M, Vedal S, et al. A national prediction model for PM2.5 component exposures and measurement error-corrected health effect inference. Environ Health Perspect 2013;121(9):1017-1025.

  25. Sheppard L, Burnett RT, Szpiro AA, Kim SY, Jerrett M, Pope CA, 3rd, et al. Confounding and exposure measurement error in air pollution epidemiology. Air Qual Atmos Health 2012;5(2):203-216.

  26. Zeger SL, Dominici F, McDermott A, Samet JM. Mortality in the Medicare population and chronic exposure to fine particulate air pollution in urban centers (2000-2005). Environ Health Perspect 2008;116(12):1614-1619.

  27. Samoli E, Peng R, Ramsay T, Pipikou M, Touloumi G, Dominici F, et al. Acute effects of ambient particulate matter on mortality in Europe and North America: results from the APHENA study. Environ Health Perspect 2008;116(11):1480-1486.

  28. Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, et al. Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA 2006;295(10):1127-1134. salud pública de méxico /vol. 56, no.4, julio-agosto de 2014 385 Challenges in air pollution research Artículo especia l

  29. Samet JM, Zeger S, Dominici F, Curriero F, Coursac I, Dockery D, et al. The National Morbidity, Mortality, and Air Pollution Study (NMMAPS). Part II. Morbidity and mortality from air pollution in the United States. Cambridge, MA: Health Effects Institute, 2000.

  30. US Environmental Protection Agency. Integrated Science Assessment for Particulate Matter (final report). Washington, DC: US Environmental Protection Agency, 2009.

  31. National Research Council, Committee on Research Priorities for Airborne Particulate Matter. Research priorities for airborne particulate matter: I. Immediate priorities and a long-range research portfolio. Washington, DC: National Academies Press, 1998.

  32. National Research Council, Committee on Research Priorities for Airborne Particulate Matter. Research priorities for airborne particulate matter: IV. Continuing research progress. Washington, DC: National Academies Press, 2004.

  33. Bell ML, Dominici F, Ebisu K, Zeger SL, Samet JM. Spatial and temporal variation in PM(2.5) chemical composition in the United States for health effects studies. Environ Health Perspect 2007;115(7):989-995.

  34. Bell ML, Ebisu K, Peng RD, Dominici F. Adverse health effects of particulate air pollution: modification by air conditioning. Epidemiology 2009;20(5):682-686.

  35. Peng RD, Bell ML, Geyh AS, McDermott A, Zeger SL, Samet JM, et al. Emergency admissions for cardiovascular and respiratory diseases and the chemical composition of fine particle air pollution. Environ Health Perspect 2009;117(6):957-963.

  36. Bell ML, Ebisu K, Leaderer BP, Gent JF, Lee HJ, Koutrakis P, et al. Associations of PM2.5 constituents and sources with hospital admissions: analysis of four counties in Connecticut and Massachusetts (USA) for persons >/= 65 years of age. Environ Health Perspect 2014;122(2):138-144.

  37. Ostro B, Roth L, Malig B, Marty M. The effects of fine particle components on respiratory hospital admissions in children. Environ Health Perspect 2009;117(3):475-480.

  38. Dominici F, Peng RD, Barr CD, Bell ML. Protecting human health from air pollution: shifting from a single-pollutant to a multipollutant approach. Epidemiology 2010;21(2):187-194.

  39. Sarnat JA, Marmur A, Klein M, Kim E, Russell AG, Sarnat SE, et al. Fine particle sources and cardiorespiratory morbidity: an application of chemical mass balance and factor analytical source-apportionment methods. Environ Health Perspect 2008;116(4):459-466.

  40. Wade KS, Mulholland JA, Marmur A, Russell AG, Hartsell B, Edgerton E, et al. Effects of instrument precision and spatial variability on the assessment of the temporal variation of ambient air pollution in Atlanta, Georgia. J Air Waste Manag Assoc 2006;56(6):876-888.

  41. Strickland MJ, Darrow LA, Mulholland JA, Klein M, Flanders WD, Winquist A, et al. Implications of different approaches for characterizing ambient air pollutant concentrations within the urban airshed for time-series studies and health benefits analyses. Environ Health 2011;10:36.

  42. Sarnat SE, Sarnat JA, Mulholland J, Isakov V, Ozkaynak H, Chang HH, et al. Application of alternative spatiotemporal metrics of ambient air pollution exposure in a time-series epidemiological study in Atlanta. J Expo Sci Environ Epidemiol 2013;23(6):593-605.

  43. Mauderly JL, Samet JM. Is there evidence for synergy among air pollutants in causing health effects? Environ Health Perspect 2009;117(1):1-6.

  44. Health Effects Institute. Traffic-Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure, and Health Effects. Special Report 17. Boston, MA: Health Effects Institute, 2009.

  45. White RH, Spengler JD, Dilwali KM, Barry BE, Samet JM. Report of workshop on traffic, health, and infrastructure planning. Arch Environ Occup Health 2005;60(2):70-76.

  46. Zhu Y, Hinds WC, Kim S, Sioutas C. Concentration and size distribution of ultrafine particles near a major highway. J Air Waste Manag Assoc 2002;52(9):1032-1042.

  47. Brauer M. How much, how long, what, and where: air pollution exposure assessment for epidemiologic studies of respiratory disease. Proc Am Thorac Soc 2010;7(2):111-115.

  48. Gan WQ, McLean K, Brauer M, Chiarello SA, Davies HW. Modeling population exposure to community noise and air pollution in a large metropolitan area. Environ Res 2012;116:11-16.

  49. Pope CA, III. Respiratory disease associated with community air pollution and a steel mill, Utah Valley. Am J Public Health 1989;79:623-628.

  50. Pope CA, III. Respiratory hospital admissions associated with PM 10 Pollution in Utah, Salt Lake, and Cache Valleys. Arch Environ Health 1991;46:90-97.

  51. Pope CA, III, Schwartz J, Ranson MR. Daily mortality and PM 10 pollution in Utah Valley. Arch Environ Health 1992;47(3):211-217.

  52. Clancy L, Goodman P, Sinclair H, Dockery DW. Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study. Lancet 2002;360(9341):1210-1214.

  53. Health Effects Institute. Proceedings of an HEI Workshop on further research to assess the health impacts of actions taken to improve air quality. Communication 15. Boston, MA: Health Effects Institute, 2010.

  54. van Erp A, Cohen A. HEI’s Research Program on the Impact of Actions to Improve Air Quality: Interim Evaluation and Future Directions. HEI Communication 14. Boston, MA: Health Effects Institute, 2009.

  55. US Environmental Protection Agency. Integrated Science Assessment of Ozone and Related Photochemical Oxidants (Final Report). Washing, DC: US Environmental Protection Agency, 2013.

  56. O’Neill MS, Jerrett M, Kawachi I, Levy JI, Cohen AJ, Gouveia N, et al. Health, wealth, and air pollution: advancing theory and methods. Environ Health Perspect 2003;111(16):1861-1870.

  57. American Lung Association. Urban air pollution and health inequities: a workshop report. Environ Health Perspect 2001;109 Suppl 3:357-374.

  58. Holloway JW, Savarimuthu-Francis S, Fong KM, Yang IA. Genomics and the respiratory effects of air pollution exposure. Respirology 2012;17(4):590-600.

  59. Zanobetti A, Baccarelli A, Schwartz J. Gene-air pollution interaction and cardiovascular disease: a review. Prog Cardiovasc Dis 2011;53(5):344-352.

  60. Peters A, Greven S, Heid IM, Baldari F, Breitner S, Bellander T, et al. Fibrinogen genes modify the fibrinogen response to ambient particulate matter. Am J Respir Crit Care Med 2009;179(6):484-491.

  61. Gilliland FD. Outdoor air pollution, genetic susceptibility, and asthma management: opportunities for intervention to reduce the burden of asthma. Pediatrics 2009;123 Suppl 3:S168-S173.




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