García MG, Izquierdo OA, Salinas FEM, Pérez DAB, Sierra VB, López RD, Vázquez ZM, Fonte GL, Guzmán TMG

Language: Spanish
References: 18
Page: 152-157
PDF size: 115.70 Kb.

ABSTRACT

Introduction: the possible role of mast cells in the pathogenesis of dengue infection has been speculated upon for years, due to its broad distribution in tissues. However, the role of mast cells in relation to dengue infection has not been explored properly.
Objective: evaluate the behavior of platelets in Balb/c mice, deficient in peritoneal masts cells, in which secondary infection is reproduced.
Methods: the behavior of platelets was evaluated in an animal model based on Balb/c mice in the presence or absence of peritoneal mast cells.
Results: results show a significant decrease in platelets, associated to the presence of mast cells (p= 0.0155).
Conclusions: results suggest a possible pathogenic role of mast cells in dengue infection.

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