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ISSN 1561-3070 (Electronic)

2014, Number 1

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Rev Cub Oftal 2014; 27 (1)

Correlation between corneal morphometry and ametrophy in LASEK

Rojas ÁE, González SJ

Language: Spanish
References: 32
Page: 38-50
PDF size: 89.64 Kb.


ABSTRACT

Objective: to establish the correlation between the corneal morphometric changes and treated ametropia one year after the corneal surgery with Excimer laser using LASEK.
Methods: prospective, observational, descriptive and longitudinal study was conducted. The sample was 111 eyes from 56 patients, who were operated on with LASEK at "Abel Santamaría" hospital in Pinar del Río province, Cuba from November 2010 through June 2011. NIDEK´s Confocal ConfoScan 4 microscopy was used to obtain and to study the in vivo corneal tissue images. The equipment was set in automatic scanning, with central fixing, image taking speed of 25 image/sec, 500x magnifying, lateral resolution of 0,6 im/pixel, 350 scanned images, and operating distance of 1,98 mm. Summary statistics, Pearson´s correlation and linear regression methods were used.
Results: after LASEK, an statistically significant correlation was observed between the size of treated ametropia and the studied variables pachymetry, corneal haze thickness and keratocyte density in the anterior stroma.
Conclusions: as the size of ametropia treated with LASEK increases, the values of pachymetry and keratocyte density in the anterior stroma decreases.


REFERENCES

  1. Benito-Llopis L, Cañadas P, Drake P, Hernández JL, Teus MA. Keratocyte density 3 months, 15 months, and 3 years after corneal surface ablation with Mitomycin C. Am J Ophthalmol. 2012;153(1):17-23.

  2. Woodward MA, Edelhauser H. Corneal endothelium after refractive surgery. J Cataract Refract Surg. 2011;37(4):767-77.

  3. Scarpa F, Zheng X, Ohashi Y, Ruggeri A. Automatic evaluation of corneal nerve tortuosity in images from in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2011;52(9):6404-08.

  4. Salvetat ML, Zeppieri M, Miani F, Parisi L, Felletti M, Brusini P. Comparison between laser scanning in vivo confocal microscopy and noncontact specular microscopy in assessing corneal endothelial cell density and central corneal thickness. Cornea. 2011;30(7):754-59.

  5. Sutton GL, Kim P. Laser in situ keratomileusis in 2010 - a review. Clin Exper Ophthalmol. 2010;38(2):192-210.

  6. Kim ST KJ, Yoon JW, Yang SW. Clinical outcomes of epi-LASIK: 1-year results of on- and off-flap procedures with and without mitomycin-C. Br J Ophthalmol. 2010;94:592-96

  7. Twa MD, Giese M. Assessment of corneal thickness and keratocyte density in a rabbit model of laser in situ keratomileusis using scanning laser confocal microscopy. Am J Ophthalmol. 2011;152(6):941-53.

  8. Linke SJ, Steinberg J, Mau-Thek E, Gisbert R, Katz T. Relationship between minimum corneal thickness and refractive state, keratometry, age, sex and left or right eye in refractive surgery candidates. J Cataract Refract Surg. 2011;37(12):2175-80.

  9. Grewal DS, Gagandeep S, Grewal S. Assessment of central corneal thickness in normal, keratoconus, and post-laser in situ keratomileusis eyes using Scheimpflug imaging, spectral domain optical coherence tomography, and ultrasound pachymetry. J Cataract Refract Surg. 2010;36(6):954-64.

  10. Dimasi DP, Burdon KP, Craig JE. The genetics of central corneal thickness. Br J Ophthalmol. 2010;94(8):971-76.

  11. Dirani M, Couper T, Yau J, Islam A, Snibson GR, Vajpayee RB, et al. Long-term refractive outcomes and stability after excimer laser surgery for myopia. J Cataract Refract Surg. 2010;36(10):1709-17.

  12. de Medeiros FW, Sinha A, Alves MR, Wilson SE, Dupps WJ. Differences in the early biomechanical effects of hyperopic and myopic laser in situ keratomileusis. J Cataract Refract Surg. 2010;36(6):947-53.

  13. Argento C, Croxatt JO. Evaluación de la celularidad estromal corneal mediante microscopía confocal en LASEK con Mitomicina. Oftalmol Clin Exp. 2007;35(1):14-20.

  14. Javaloy J, Vidal MT, Ruiz JM, Alió JL. Microscopía confocal de la córnea en la cirugía foforrefractiva. Arch Soc Esp Oftalmol. 2005;80(9):497-509.

  15. Moilanen JAO, Vesaluoma M, Müller LJ, Tervo T. Long-Term corneal morphology after PRK by in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 2003;44(3):1064-69.

  16. Nakamura K, Kurosaka D, Bissen-Miyajima H, Tsubota K. Prevention of stromal haze after laser assisted in Intact corneal epithelium is essential for the situ keratomileusis. Br J Ophthalmol. 2001(2);85:209-13.

  17. McLaren JW, Bourne WM, Patel SV. Standardization of corneal haze measurement in confocal microscopy. Invest Ophthalmol Vis Sci. 2010;51(11):5610-16.

  18. Park C, Kim J. Comparison of wound healing after photorefractive keratectomy and laser in situ keratomileusis in rabbits. J Cataract Refract Surg. 1999;25(6):842-50.

  19. Erie JC, Patel SV, McLaren JW, Maguirre LJ, Ramírez M, Bourne WM. Keratocyte density in vivo after photorefractive keratectomy in humans. Trans Am Ophthalmol Soc. 1999;97:221-36.

  20. Poole BN, Clover GM. Keratocyte networks visualized in the living cornea using vital dyes. J Cell Sci. 1993;106:685-92.

  21. Wallau AD, Campos M. One-year outcomes of a bilateral randomised prospective clinical trial comparing PRK with mitomycin C and LASIK. Br J Ophthalmol. 2009;93(12):1634-38.

  22. Dawson DG, Kramer T, Grossniklaus HE, Waring G, Edelhauser H. Histologic, ultraestructural and inmunofluorescent evaluation of human laser in situ keratomileusis corneal wounds. Arch Ophthalmol. 2005;123(6):741-56.

  23. Jester JVM-PT, Huang J. The cellular basis of corneal transparency: evidence for corneal crystallins. J Cell Sci. 1999;112:613-22.

  24. Dawson DG, Edelhauser H, Grosshiklaus HE. Long term histopathologic findings in human corneal wounds after refractive surgical procedures. Am J Ophthalmol. 2005;139(1):168-76.

  25. Darwish T, Brahma A, Efron N, O'Donnell C. Subbasal nerve regeneration after LASEK measured by confocal microscopy. J Refract Surg. 2007;23(7):709-15.

  26. Dimitri A, Pluznik D, Sandeep J, Khoury J. Gelatinase B and A expression after laser in situ keratomileusis and photorefractive keratectomy. Arch Ophthalmol. 1998;116(9):1206-08.

  27. Li J, Wang Y. Characteristics of straylight in normal young myopic eyes and changes before and after LASIK. Invest Ophthalmol Vis Sci. 2011;52(6):3069-73.

  28. Patel SV, Bourne W. Corneal endothelial cell loss 9 years after excimer laser keratorefractive surgery. Arch Ophthalmol. 2009;127(11):1423-27.

  29. Anderson NJ, Edelhauser H, Sharara N, Thompson KP, Rubinfeld RS, Devaney DM, et al. Histologic and ultrastructural findings in human corneas after successful laser in situ keratomileusis. Arch Ophthalmol. 2002;120(3):288-93.

  30. Masters BR, Böhnke M. Three-dimensional confocal microscopy of the living human eye. Annu Rev Biomed Eng. 2002;4:69-91.

  31. Tavakoli M, Hossain P, Malik RA. Clinical applications of corneal confocal microscopy. Clinical Ophathalmology. 2008;2(2):435-45.

  32. Nubile M, Mastropasqua L. In vivo confocal microscopy of the ocular surface: where are we now? Br J Ophthalmol. 2009;93(7):850-52.




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