Barrientos-Alvarado C, Cárdenas-Oscoy AS, Vázquez-Sánchez J, Garrido-Acosta O

Language: Spanish
References: 24
Page: 224-230
PDF size: 208.61 Kb.

ABSTRACT

The glucosamine can contribute to insulin resistance and interfere with the glucose metabolism favoring the hexosamine biosynthetic pathway, and increased final products (UDP–N–acetylglucosamine), and the synthesis of leptin messenger RNA on muscle and adipocytes cells of rat. Female rats were administered with oral glucosamine equivalent to 300 (exp:1 nulipara) and 900 (exp:2, gestation) mg/kg daily for 11 and 15 weeks respectively. And was measured body weight, intake food, blood glucose levels and insulin, leptin and triglycerides in plasma and the curve glucose tolerance and insulin tolerance. The aim was to evaluate the effect of glucosamine on body weight and during pregnancy in rats. No difference was observed in feed intake, and leptin levels in plasma triglycerides for any dose. Curves glucose tolerance showed higher blood glucose concentrations at 60 and 120 min later with respect to the control group (ANOVA, p ‹ 0.05), both doses of glucosamine without alteration in plasma insulin levels, the curve insulin tolerance observed a decrease in blood glucose in both groups, without significant, in the offspring was not observed changes in blood glucose and body weight showed only up to day 35 postpartum be greater for the offspring of mothers with glucosamine with a dose of 900 mg/kg/day. Concluded that glucosamine orally administered at doses of 300 and 900 mg/kg/day in rats, daily for eleven and fifteen weeks respectively not affect food intake, body weight and leptin secretion, not produce insulin resistance, any significant changes during pregnancy in glucose metabolism. Is recommended to monitor blood glucose levels, as it is presumed may arise glucose intolerance in rat.

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