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ISSN 2007-4360 (Print)
Asociación Mexicana de Periodontología, Colegio de Periodoncistas A.C

2013, Number 3

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Rev Mex Periodontol 2013; 4 (3)

Relationship between the expression of IFN-γ receptor and angiogenesis in gingival tissue samples from patients with chronic and aggressive periodontitis
Second place winner in the Research contest, Asociación Mexicana de Periodontología. More

Herrera MMC, Martínez RV, Zamora PAL, Sánchez HPE, Franco TR, Guerrero VC

Language: Spanish
References: 28
Page: 106-113
PDF size: 519.90 Kb.


ABSTRACT

Introduction: Chronic and aggressive periodontitis are characterized by gingival insertion loss and alveolar bone destruction. However, insertion loss is faster in aggressive periodontitis than in the chronic variety. The immune-inflammatory response and the angiogenesis in periodontitis is initiated by the release of a wide variety of molecules, including IL-12, IL-18, IFN-γ and their receptors on T and NK cells. It has been reported that levels of IL-12 and IL-18 in patients with aggressive periodontitis are different to those in individuals with the chronic one. Nevertheless, these cytokine receptors have not been studied regarding this pathology. Material and methods: IFN-γR expression was detected by immunohistochemistry in gingival tissue samples of people with chronic periodontitis, aggressive periodontitis and healthy subjects. Results: We found no significant differences in the IFN-γ expression (Mann-Whitney U) of the three groups, but we did observe an increased IFN-γR2 expression in the endothelial cells of all groups. We could also notice a significant increase in the vascularity and vessel diameter of the patients with aggressive and chronic periodontitis when compared to healthy subjects. Conclusions: We detected an increased vascularity in patients with aggressive and chronic periodontitis, as well as an increase in the expression of IFN-γR2 in all the study groups.


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