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2012, Number 2

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RCAN 2012; 22 (2)

Ganancia de peso, dismetabolia y función renal al año del trasplante renal

Borroto DG, Quintanilla AM, Barceló AM, Cabrera VL

Language: Spanish
References: 38
Page: 186-202
PDF size: 155.79 Kb.


ABSTRACT

Rationale: Excessive weight gain might increase the risk of insulin resistance and Metabolic Syndrome in the kidney-transplanted patient at. Objectives: To assess the influence of patient’s sex and age, type of kidney donor (Living Donor/Cadaver), primary disease leading to the loss of kidney function, immunosupression protocol and kidney transplant function (measured from serum creatinine) upon weight gain one year after kidney transplantation; and also, association of observed weight gain with several of the facets of the Metabolic syndrome. Study design: Retrospective, analytical. Study serie: Kidned-transplanted outpatients older than 18 years, who completed one year of grafting, and were assisted at the Service of Nephrology, “Hermanos Ameijeiras” Hospital (Havana City, Cuba). Immunosuppressive therapy consisted of cyclosporine A, prednisone and/or an antimetabolite. Methods: Weight gain was calculated as [Weight one year after transplant–Weight pre-transplant]. Weight gain was distributed according with the study variables. Results: Excess body weight affected 56.8% of the serie (Obesity: 19.3%). Forty-four percent of the patients gained more than 10 Kg in the year following grafting. Women, patients receiving a kidney from a living donor, and twomedications immunosuppressive protocols showed the highest weight gain values. Blood lipids disorders and Metabolic syndrome were associated with the highest weigh gain values. Glomerular filtration rate and proteinuria were independent of weight gain. Conclusions: Weight gain was excessive in almost half of the transplanted patients, and was associated with several of the facets of the Metabolic syndrome.


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