2014, Number S2
<< Back Next >>
Rev Med Inst Mex Seguro Soc 2014; 52 (S2)
Antimicrobial resistance in uropathogens isolated in a pediatric hospital
Pérez-Pérez A, Peregrino-Bejarano L, Camacho-Velázquez M, Miranda-Novales MG
Language: Spanish
References: 20
Page: 44-49
PDF size: 66.24 Kb.
ABSTRACT
Background: Urinary tract infection is one of the most common infections
at all ages. Antimicrobial resistance has increased in the past few years.
The aim of this study was to determine the most common etiologic agents
of urinary tract infections and their antimicrobial susceptibility profiles.
Methods: A descriptive, cross-sectional survey was conducted. Patients
with a urinary tract infection identified over a 1-year period were
included. The type of infection, risk condition, antimicrobial treatment,
microorganism and antimicrobial susceptibility were recorded. Statistical
analysis: descriptive statistics.
Results: One hundred and seventy four patients with infection, 31.4 %
with urinary tract malformation, 56 % with functional abnormalities.
76.4 % were receiving antimicrobial prophylaxis.
Escherichia coli was
the most common agent isolated with 67%, followed by
Klebsiella spp.
9 %,
Pseudomonas spp. 7 % and others less frequently.
Escherichia coli
resistance to cephalotin was 58.7%, to norfl oxacin 51 %, nitrofurantoin
15.5 %, cefuroxime 12.5 %, cefotaxime 15.5 %, cefepime 5 % and to
amikacin 0 %.
Conclusions: Escherichia coli was the most common causative agent,
and resistance to quinolones and cephalotin was higher than 50 %.
Most patients had urinary tract functional abnormalities and a history of
prophylactic treatment use. Options other than quinolones need to be
assessed due to the high resistance identified in uropathogens.
REFERENCES
Cavagnaro F. Infección urinaria en la infancia. Rev Chilena Infectol. 2005;22(2):161-8.
Ginsburg CM, McCraken GH Jr. Urinary tract infections in young infants. Pediatrics. 1982;69(4):409-12.
Díaz-Ponce H, Sandoval-Mex AM. Infección de vías urinarias en pediatría. Enf Infec Micro. 2002;22(1):14-9.
Langley JM, Hanakowski M, LeBlanc JC. Unique epidemiology of nosocomial urinary tract infection in children. Am J Infect Control. 2001;29(2):94-8.
Lohr JA, Donowitz LG, Sadler JE. Hospital-acquired urinary tract infection. Pediatrics. 1989;83(2):193-9.
Ma JF, Shortliffe LM. Urinary tract infection in children: Etiology and epidemiology. Urol Clin North Am. 2004;31(3):517-26.
Matlow AG, Wray RD, Cox PN. Nosocomial urinary tract infections in children in a pediatric intensive care unit: A follow-up after 10 years. Pediatr Crit Care Med. 2003;4(1):74-7.
Ladhani S, Gransden W. Increasing antibiotic resistance among urinary tract isolates. Arch Dis Child. 2003;88(5):444-5.
Mazzulli T. Resistance trends in urinary tract pathogens and impact on management. J Urol. 2002;168(4 Pt 2):1720-2.
Komp-Lindgren P, Marcusson LL, Sandvang D, Frimodt-Moller N, Hughes D. Biological cost of single and multiple norfl oxacin resistance mutations in Escherichia coli implicated in urinary tract infections. Antimicrob Agents Chemother. 2005;49(6):2343-51.
Gales AC, Jones RN, Gordon KA, Sader HS, Wilke WW, Beach ML, et al. Activity and spectrum of 22 antimicrobial agents tested against urinary tract infection pathogens in hospitalized patients in Latin America: Report from the second year of the SENTRY antimicrobial surveillance program (1998). J Antimicrob Chemother. 2000;45(3):295-303.
Barriga-Angulo G, Rojas-Molina L, Peredo-López Velarde MA. Actualidades en los patrones de resistencia a los antimicrobianos en un centro médico nacional. Rev Mex Patol Clin. 2001;48(2):65-9.
Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing: Fifteenth informational supplement. CLSI, document M100-S15. Wayne, PA: CLSI; 2005.
Le Saux N, Pham B, Moher D. Evaluating the benefi ts of antimicrobial prophylaxis to prevent urinary tract infections in children: A systematic review. CMAJ. 2000;163(5):523-9.
Conway PH, Cnaan A, Zaoutis T, Henry BV, Grundmeier RW, Keren R. Recurrent urinary tract infections in children: Risk factors and association with prophylactic antimicrobials. JAMA. 2007;298(2):179-86.
Díaz-Rigau L, Cabrera-Rodríguez LE, Fernández- Núñez T, González-Febles O, Carrasco-Guzmán M, Bravo L. Etiología bacteriana de la infección urinaria y susceptibilidad antimicrobiana en cepas de Eschericia coli. Rev Cubana Pediatr. 2006;78(3):245-52.
Cornejo-Juárez P, Velásquez-Acosta C, Sandoval S, Gordillo P, Volkow-Fernández P. Patrones de resistencia bacteriana en urocultivos en un hospital oncológico. Salud Publica Mex. 2007;49(5):330-6.
Aguirre-Alvarado H, Plascencia-Hernández A, Rivera- Mendoza CC, Guerrero-Becerra M, Murillo-Neri V. Resistencia de Escherichia coli en infecciones de vías urinarias en pacientes pediátricos del Hospital Civil de Guadalajara “Fray Antonio Alcalde”. Enf Inf Microbiol. 2007;27(3):83-7.
Marcus N, Ashkenazi S, Yaari A, Samra Z, Livni G. Non Escherichia coli versus Escherichia coli community- acquired urinary tract infections in children hospitalized in a tertiary center: Relative frequency, risk factors, antimicrobial resistance and outcome. Pediatr Infect Dis J. 2005;24(7):581-5.
Arredondo-García JL, Soriano-Becerril D, Solórzano- Santos F, Arbo-Sosa A, Coria-Jiménez VR. Etiología y tratamiento de infecciones de vías urinarias (UTIS) en niños. Rev Enfer Infec Pediatr. 2006;19 (76):100-6.