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2014, Number S2

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Rev Med Inst Mex Seguro Soc 2014; 52 (S2)

Clinical characteristics of pediatric patients treated for infl uenza A (H1N1). The 2009 pandemic in Mexico

Fuentes-Pacheco YC, Flores-Ruiz EM, Solórzano-Santos F, Meza-Chávez A, Zamudio-Lugo I, Vázquez-Rosales JG, Miranda-Novalese MG

Language: Spanish
References: 26
Page: 8-15
PDF size: 86.38 Kb.


ABSTRACT

Background: Pandemicinfluenza A (H1N1) virus was first reported in April 2009. The aim of this study is to describe the clinical course of patients with influenza-like illness treated in a tertiary care pediatric hospital.
Methods: Cross-sectional analytical study, encompassing the period from April 2009 to March 2010. Clinical and demographic information was obtained from clinical records. Data analysis was carried out using descriptive statistics, using a univariate analysis with the chi-square test, the exact Fisher test, and the Mann-Whitney U test for quantitative variables.
Results: 240 patients were included, out of which 53.9 % were female; median age was 5 years. Sixty four cases (26.6 %) were confirmed, 38 % had and underlying condition, and 10 % had received the influenza vaccine. One hundred and sixteen patients (48 %) were hospitalized. With regard to mortality, 10 out of 64 confi rmed cases died, 3 of the 86 of the disregarded cases, and 2 of 90 without a confi rmatory test died (p ‹ 0.05). The patients who died started antiviral treatment on day 7; conversely, those who survived started the treatment on day 4 (p ‹ 0.05).
Conclusions: Lethality was higher in patients with confirmed infection. Antiviral treatment within the first 48 hours was observed to be essential for patients with risk for the development of complications.


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