medigraphic.com
Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2014, Number 1

<< Back Next >>

Rev Biomed 2014; 25 (1)

Concentrations of leptin and its correlation with the components of metabolic syndrome (MS) and body mass index (BMI)

Galván-Meléndez MF, Lares-Bayona EF, Quintanar-Escorza MA, Carrera-Gracia MA, Torres-Castorena A

Language: Spanish
References: 36
Page: 23-30
PDF size: 443.51 Kb.


ABSTRACT

Introduction. Leptine is an adipokine synthesized and secreted mainly by adipose tissue, whose concentration is proportional to the mass of this tissue, while metabolic syndrome is a complex and heterogeneous clinical entity with a strong genetic component, in patients with generally higher amounts of adipose tissue.
Objective. Evaluate the concentrations of leptin and its correlation with the components of metabolic syndrome (MS) and BMI.
Materials and Methods. Transverse and correlation observational studies made during the period of May-September of 2011 included 50 women between 30-50 years old with metabolic syndrome (MS) evaluated according to the ATPIII criteria, determined by serum leptin levels. A descriptive and inferential statistic in the SPSSv19® program was used to evaluate the results. Patient anonymity and confidentiality were respected in creating and reporting results.
Results. 50 women were evaluated, average age of 41.8±6.7 years, with an average BMI of 32.9±5.9 kg/m2, and average leptin concentration of 41.9±16.2 ng/dL. Of the components of MS, 100% of the patients had a waist index ≥88cm, followed by hypertriglyceridemia in 80% of them, and hypoalphalipoproteinemia in 75% of them. A correlation was found between the leptin concentrations and waist index and also between the leptin concentrations and BMI with “r” values of 0.306 and 0.439 respectively, with a p ‹0.05 in both correlations.
Conclusions. Weak correlations were found between leptin concentrations with both waist index and BMI, however; the correlation found between leptin concentrations and BMI were higher.


REFERENCES

  1. García-García E, De la Llata-Romero M, Kaufer- Horwitz M, Tusié-Luna MT, Calzada-León R, Vázquez-Velázquez V, et al. La obesidad y el síndrome metabólico como problema de salud pública. Una reflexión. Arch Cardiol Méx. 2008 Julio-Septiembre; 78(3):318-337.

  2. Nikolopoulou A, Kadoglou NP. Obesity and metabolic syndrome as related to cardiovascular disease. Expert Rev Cardiovasc Ther. 2012 Jul; 10(7):933-9.

  3. Quia Q, Gao W, Zhang L, Nyamodorj R, Tuomilehto J. Metabolic syndrome and cardiovascular disease. Ann Clin Biochem. 2007 May; 44(Pt 3):232-63.

  4. Osuji Charles U and Omejua Emeka G. Prevalence and characteristics of the metabolic syndrome among newly diagnosed hypertensive patients. Indian J Endocrinol Metab. 2012 Mar; 16(suppl. 1):S104-9.

  5. Canale MP, Manca di Villahermosa S, Martino G, Rovella V, Noce A, De Lorenzo A, et al. Obesity- Related metabolic Syndrome: Mechanisms of Sympathetic Overactivity. Int J Endocrinol. 2013 October.

  6. Yun-Jung B, Se-Hong K, Ju-Hye CH, Sang-Wook S, Kyung-Soo K, Mi-Kyung K, et al. Evaluation of Adiposity-Related Biomarkers as Metabolic Syndrome Indicators. Clin Nutr Res. 2013 July; 2(2): 91–99.

  7. Sheng Jiang and Zijing Xie. Comparision study of metabolic syndrome´s differences and diagnostic criteria´s Applicability among Xingjiang Uighur, Kazak and Han Population. Indian J Endocrinol Metab. 2012 Sep; 16(1):7-12.

  8. Grundy Scott M, Cleeman James I, Daniels Stephen R, Donato Karen A, Eckel Robert H, Franklin Barry A, et al. Diagnosis and Management of the Metabolic Syndrome. Circulation. 2005; 112: 2735-2752.

  9. Rakesh M Parkih, Viswanathan Mohan. Changing definitions of metabolic syndrome. Indian J Endocrinol Metab. 2012 Jan; 16(1):7-12.

  10. Abbas Rezaianzadeh, Seyedh-Mahdieh Namayandeh and Seyed-Mahmood Sadr. National Cholesterol Education Program Adult Treatment Panel III Versus International Diabetic Federation Definition of Metabolic Syndrome, Which One is Associated with Diabetes Mellitus and Coronary Artery Disease?. Int J Prev Med. 2012 Aug; 3(8):552-558.

  11. Gutiérrez JP, Rivera-Dommarco J, Shamah-Levy T, Villalpando-Hernández S, Franco A, Cuevas- Nasu L, Romero-Martínez M, Hernández-Ávila M. Encuesta Nacional de Salud y Nutrición 2012. Resultados Nacionales. Cuernavaca, México: Instituto Nacional de Salud Pública (MX), 2012.

  12. Gonzalo Martínez R, Rodrigo Alonso K, Victoria Novik A. Síndrome metabólico. Bases clínicas y fisiopatológicas para un enfoque terapéutico racional. Rev Méd Chile 2009 Mayo; 137: 685-94.

  13. Douchi T, Iwamoto I, Yoshimitsu N, Ohishi Y, Nagata Y. Differences in leptin production by regional fat mass in postmenopausal women. Endocr J. 2002 Aug; 49 (4): 413-6.

  14. Hu F, Chen C, Wang B, Stampfer M, Xu X. Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population. Int J Obes. 2001 Jan; 25(1):121-25.

  15. Bates S, Myers M. The role of leptin-Stat 3 signaling in neuroendocrine function an integrative perspective. J Mol Med. 2004 Jan; 82(1):12-20.

  16. Kajikawa Y, Ikeda M, Takemoto S, Tomoda J, Ohmaru N, Kusachi S. Association of circulating levels of leptin and syndrome in a with metabolic syndrome and coronary heart disease in patients with various coronary risk factors. Int Heart J. 2011; 52(1): 17-22.

  17. Barrios Y., Díaz N., Meertens L., Naddaf G., Solano L., Fernández M., et al. Leptina sérica, su relación con peso y distribución de grasa corporal en mujeres posmenopáusicas. Nutr. Hosp. 2010 enero-febrero; 25(1):80-84.

  18. Hassanzadeh T, Maleki M, Saidijam M, Paoli M. Association between leptina gene G-2548A polymorphism with metabolic syndrome. J Res Med Sci. 2013 August; 18(8): 668–673.

  19. Esteaghamati A, Noshad S, Khalilzadeh O, Morteza A, Nazeri A, Meysamie A, et al. Contribution of serum leptin to metabolic syndrome in obese and nonobese subjects. Arch Med Res. 2011 Apr; 42(3): 244-51.

  20. Mishra S, Harris TB, Hue T, Miljkovic I, Satterfield S, de Rekeneire N, et al. Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults. J Nutr Metab. 2013; 2013

  21. Surivaprom K, Tungtrongchitr R, Thawnasom K. Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223 Arg and BDNF Val66Met in thai with metabolic syndrome. Diabetol Metab Syndr. 2014; 6: 6.

  22. Yadav A, Jyoti P, Jain SK, Bhattacharjee J. Correlation of Adiponectin and leptin with Insulin Resistance: A Pilot Study in Healthy North Indian Population. Indian J Clin Biochem. 2011 April; 26(2): 193–196.

  23. Jiménez MC. Niveles séricos de leptina e insulina en sujetos obesos y no obesos. An. Fac. Cienc. Méd. (Asunción). 2005 abr; 38 (1-2):55-62.

  24. Mantzoros CS, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno TA, Sang-Yong K, et al. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab. 2011 October; 301(4): E567–E584.

  25. Albala BC, Pérez BF, Santos MJL, Yáñez GM, Arroyo AP, Díaz CJ, et al. Relación entre leptina e insulina sanguíneas en mujeres chilenas obesas y no obesas. Rev. Méd. Chile. 2000 feb.; 128(2).

  26. Contreras-Leal EA, Santiago-García J. Obesidad, síndrome metabolico y su impacto en las enfermedades cardiovasculares. Rev Biomed 2011; 22:103-115.

  27. Coniglio RI, Nellem J, Sibechi N, Colombo O. Síndrome metabólico: frecuencia de sus componentes y riesgo global de cardiopatía coronaria. Acta Bioquím Clín Latinoam 2011; 45 (3): 413-21.

  28. Castro-Sansores CJ, Hernández-Escalante V, Arjona-Villicaña R. Prevalencia del Síndrome Metabólico en sujetos adultos que viven en Mérida, Yucatán. México. Rev Biomed 2011; 22:49-58.

  29. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentration in normal-weight and obese humans. N Engl J Med. 1996;334:292–295

  30. Bennasar-Veny M, López-González AA, Tauler P, céspedes ML, Vicente-Herrero T, Yáñez A, et al. Body Adiposity Index and Cardiovascular Health Risk Factors in Caucasians: A Comparison with the Body Mass Index and Others. PloS One. 2013; 8(5).

  31. Martins Mdo M, Lima Faleiro L, Fonseca A. Relationship between leptin and body mass and metabolic syndrome in an adult population. Rev Port Cardiol. 2012 Nov; 31(11): 711-9.

  32. Ntyintyane L, Panz V, Raaj FJ, Gill G. Leptin, adiponectina, and high-sensitivity C-reactive protein in relation to the metabolic sybdrome in urban South African blacks with and without coronary artery disease. Metabol Syndr Relat Disord. 2009 Jun; 7(3): 243-8.

  33. Adamj GF, Civalleri D, Cella F, Marinari G, Camerini G, Papadia F, et al. Relationships of serum leptin to clinical and anthropometric findings in obese patients. Obes Surg. 2002 Oct; 12(5):623-7.

  34. Feng-Hsiang Chiu, Chung Hsun Chuang, Wen- Cheng Li, Yi-Ming Weng, Wen-Chih Fann, Hsiang-Yun Lo, et al. The association of leptin and C-reactive protein with the cardiovascular risk factors and metabolic syndrome score in Taiwanese adults. Cardiovasc Diabetol. 2012 Apr; 11: 40

  35. Zamboni M, Zoico E, Fantin F, Panourgia MP, Di Francesco V, Tosoni P, et al. Relation between leptin and the metabolic syndrome in elderly women. J Gerontol A Biol Sci Med Sci. 2004 Apr; 59 (4): 396-400.

  36. Hamnvik OP, Liu X, Petrou M, Gong H, Chamberland JP, Kim EH, et al. Soluble leptin receptor and leptin are associated with baseline adiposity and metabolic risk factors, and predict adiposity, metabolic syndrome, and glucose levels at 2-year follow-up: the Cyprus Metabolism prospective Cohort Study. Metabolism. 2011 Jul; 60(7):987-93.




2020     |     www.medigraphic.com