Rojas CMA, Garavito CG, Rincón VJ

Language: Spanish
References: 15
Page: 69-75
PDF size: 78.59 Kb.

ABSTRACT

Introduction: plant species of the genus Piper (Piperaceae) have been used in traditional medicine in various regions of the world. In Latin America they have been used to treat tropical diseases such as malaria.
Objective: evaluate the antiplasmodial activity of the ethanolic extract and fractions of varying polarity of Piper holtonii C. DC.
Methods: evaluation was conducted of the antiplasmodial activity of ethanolic extract from aerial parts of Piper holtonii and of hexane, chloroform, methanol, buthanol and aqueous fractions on a Plasmodium falciparum strain FCB-2 culture. Hemolytic activity was determined and phytochemical characterization of each fraction was performed.
Results: both the ethanolic extract and the low-polarity fractions displayed promising activity, with CI₅₀ values below 25 µg/mL.
Conclusions: results concerning the biological activity of Piper holtonii suggest that low-and medium-polarity metabolites are related to antiplasmodial activity in this species.

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