medigraphic.com
ISSN 1561-2929 (Print)

2012, Number 1

<< Back Next >>

RCAN 2012; 22 (1)

Morphology and function of the small bowel in rat pups bred following an intrauterine growth retardation model

Martínez MM, Gámez FM, González SC, Rodríguez SVM, Hidalgo CT, Herrera ÁME

Language: Spanish
References: 80
Page: 7-28
PDF size: 259.66 Kb.


ABSTRACT

Fetal development is characterized by sequential patterns of organ and tissue growth and maturation determined by maternal milieu, uterine-placental function and the genetic growth potential that is inherent to the fetus. Limitation of this potential growth is termed Intrauterine Growth Retardation (IUGR). Physiopathological alterations accompanying this entity contribute to derangement of intestinal function, and increase the occurrence of nutritional disorders during extrauterine life. Rats bred according with an IUGR. model induced after ligature of uterine arteries of the mother’s uterine horns showed diminished values of somatometric, biochemical and morphofunctional variables of the study. Descriptive variables of the intestinal morphofunction associated closely with nutritional indicators used in the description of the animal’s nutritional status. Results discussed sustain the usefulness of the restrictive model used in this study.


REFERENCES

  1. Metcoff J, Costiloe J, Crosby W, Bentle L, Seshachalam D, Sandstead HH et al. Maternal nutrition and fetal outcome. Am J Clin Nutr 1981;34:708-21.

  2. Ramachandran P. Maternal nutritioneffect on fetal growth and outcome of pregnancy. Nutr Rev 2002;60(5 Pt 2): S26-S34.

  3. Daniels J. Fetomaternal interaction. En: Neonatology (Editor: Avery GB). JB Lippincot Co. Philadelphia:1997. pp 97- 109.

  4. Warshaw JB. Intrauterine growth restriction revisited. Growth, Genetics & Hormones 1992; 8.5-8.

  5. Division of Family Health. World Health Organization. The incidence of low birth weight: a critical review of available information. World Health Stat Q 2005; 33:197-224.

  6. Carrera JM. Crecimiento intrauterino retardado: concepto y frecuencia. En: Crecimiento Fetal Normal y Patológico (Editor: Carrera JM). Masson SA. Barcelona:1997. pp 219-224.

  7. Hill RM, Verniaud WM, Deter RL, Tennyson LM, Rettig GM, Zion TE et al. The effect of intrauterine malnutrition on the term infant: A 14-year prospective study. Acta Paediatric Scand 1984;73:482-7.

  8. Ballabriga A. Crecimiento intrauterino. An Esp Pediatr 1995;70:91-7.

  9. Battaglia FC, Meschia G. Fetal Nutrition. Ann Rev Nutr 1999;8:43-61.

  10. Gluckman PD, Harding JE. Nutritional and hormonal regulation of fetal growthevolving concepts. Acta Paediatr 1994;399(Suppl):60-3.

  11. Cedard L. The endocrine functions of the placenta. Interactions between trophic peptides and hormones. En: Placental function and fetal nutrition (Editor: Battaglia FC). Workshop Series 39. Lippincott-Raven. Philadelphia: 1997. pp 59-74.

  12. Toubas PL. Placental circulation and fetal growth. En: Intrauterine Growth Retardation (Editor: Senterre J). Raven Press. New York: 1999. pp 1-21.

  13. Owens JA, Kind KL, Robinson JS. Oxygenation in utero: Placental determinants and fetal requirements. En: Placental function and fetal nutrition (Editor: Battaglia FC). Workshop Series 39. Lippincott-Raven. Philadelphia: 1997. pp. 123-141.

  14. Milner RD, Hill DJ. Fetal growth control. The role of insulin and related peptides. Clin Endocrinol (Oxf) 1994; 21:415-33.

  15. Hill DJ, Milner RDG. Mechanisms of fetal growth. En: Clinical Paediatric Endocrinology (Editor: Brook CGD). Blackwell Scientific Publications. Oxford: 1999. pp. 3-31.

  16. Karlsson K. The influence of hypoxia on uterine and maternal placental blood flow and the effect of L-adrenergic blockade. J Perinatol Med 1984;12: 168-76.

  17. Caldeyro Barcia R. Fetal malnutrition: The role of maternal blood flow. Hosp Pract 1970;6: 3343.

  18. Robinson JS, Owens JA, Owens PC. Fetal growth and fetal growth retardation. En: Textbook of Fetal Physiology (Editores: Thorburn GD, Harding R). Oxford University Press. Oxford: 1994. pp. 83-94.

  19. Hales CN. Metabolic consequences of intrauterine growth retardation. Acta Paediatr 1997; 423(Suppl):184-7.

  20. Mortaz M, Fewtrel MS, Cle TJ, Lucas A. Birth weight subsequent growth and cholesterol metabolism in children of 8 – 12 years old born preterm. Arch Dis Child 2001;84:212-7.

  21. Ferro-Luzzi A, Ashworth A, Martorell R, Scrimshaw N. Report of the IDECG Working Group on effects of IUGR on infants, children and adolescents: immunocompetence, mortality, morbidity, body size, body composition, and physical performance. Eur J Clin Nutr 1998;52(Suppl 1):S97-S99.

  22. Ibañez L, Potau N, de Zegher F. Precocious pubarche, dyslipidemia, and low IGF binding protein-1 in girls: Relation to reduced prenatal growth. Pediatr Res 1999;46:320-2.

  23. Barker DJP. Fetal growth and adult disease. J Obstet Gynaecol 1992;99:275- 82.

  24. Barker DJP. The fetal origins of diseases of old age. Eur J Clin Nutr 1992;46(Suppl 3):3-9.

  25. Barker DJP. The fetal origins of coronary heart disease. Acta Paediatr 1997;422(Suppl):78-82.

  26. Phillips DIW, Barker DJP, Hales CN, Hirst S, Osmond C. Thinness at birth and insulin resistance in adult life. Diabetologia 1994;37:150-4.

  27. Barker DJP, Godfrey KM, Gluckman PD, Harding JE, Owens JA, Robinson JS. Fetal nutrition and cardiovascular disease in adult life. Lancet 1993;341:938-41.

  28. Barker DJP, Bull AR, Osmond C, Simmonds SJ. Fetal and placental size and risk of hypertension in adult life. Br Med J 1990;301:259-62.

  29. Guyton AC, Hall JE. Digestión y absorción en el aparato gastrointestinal. En: Tratado de Fisiología Médica. Décima Edición. McGraw-Hill Interamericana. Madrid: 2002. pp.903- 15.

  30. Cotran RS, Kumar V, Collins T. Aparato gastrointestinal. En: Patología Estructural y Funcional (Editor: Robbins). Sexta Edición. McGraw-Hill Interamericana. Madrid: 2000. pp. 809- 880.

  31. Fawcett DW. Intestinos. En: Tratado de Histología. Duodécima Edición. McGraw-Hill Interamericana. Madrid: 1995. pp. 675-707.

  32. Ariyuki F. Growth retardation induced in rat fetuses by maternal fasting and massive doses of ergocalciferol. J Nutr 1987;117:342-8.

  33. Hayash TT, Dolks ME. A rat model for the study of intrauterine growth retardation. Am J Obstetric Gynecol 1988;158:1203-7.

  34. Tomé O, Alfonso C. Obtención experimental de crías con crecimiento intrauterino retardado. Rev Cubana Cienc Vet 2000;26:39-41.

  35. Tomé O, Alfonso C. Comportamiento postnatal de variables somatométricas en crías de rata con crecimiento intrauterino retardado experimental. Rev Cubana Cienc Vet 2001;27:15-7.

  36. Tomé O, Alfonso C. Comportamiento de valores de la química sanguínea en crías de ratas con crecimiento intrauterino retardado. Rev Cubana Cienc Vet 2003;39:27.

  37. Lowry OH, Rose Broygh NJ, Farr AL, Randal RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:67-73.

  38. Dalqvist A. Method for assay of intestinal disacharidases. Anal. Biochem 1994;25:18-25.

  39. Newey H, Smyth DH, Whaler BC. The absorption of glucose by the in vitro intestinal preparation. J Physiol 1955;129:1–11.

  40. Hernández A. Albúmina. En: La clínica y el laboratorio. Décimo octava Edición. Ediciones Médicas SA. Madrid: 1999. pp 34-36.

  41. Siedel J, Hagele EO, Ziegenhorn J, Wahlefeld AW. Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem 1983;29:1075-80.

  42. Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 1969;6:24-5.

  43. Rodríguez A. Leucograma. En: La clínica y el laboratorio. Décimo octava Edición. Ediciones Médicas SA. Madrid: 1999. pp 20-25.

  44. Hare RS. Endogenus creatinine in serum and urine. Proc Soc Exp Biol Med 1950;74 (148):45-9.

  45. Siegel S. Estadística no Paramétrica. Segunda Edición. Editorial Trillas. México: 1974.

  46. Martínez Canalejo H, Santana Porbén S. Manual de Procedimientos Bioestadísticos. Editorial Ciencias Médicas. La Habana: 1990.

  47. Wiglesworth JS. Experimental growth retardation in the fetal rat. J Pathol Bacteriol 1964;88:1-13.

  48. Hohenauer L, Oh W. Body composition in experimental growth retardation in the rat. J Nutr 1969;99:23-6.

  49. Cruz García M. Estudio morfológico del intestino delgado en ratas con crecimiento intrauterino retardado. Instituto Superior de Ciencias Médicas de la Habana. Trabajo de Terminación de Residencia en Embriología. MINSAP Ministerio de Salud Pública. La Habana: 1991.

  50. Álvarez Y. Estudio de la morfometría en órganos de crías de ratas con crecimiento intrauterino retardado. Instituto Superior de Ciencias Médicas de la Habana. Trabajo de Terminación de Residencia en Embriología. MINSAP Ministerio de Salud Pública. La Habana: 2007.

  51. Cha CJ, Gelardi NL, Oh W. Growth and cellular composition in the rat with intrauterine growth retardation: Effect of postnatal nutrition. J Nutr 1987;117:1463-8.

  52. Patel D, Kalhan S. Glycerol metabolism and triglyceride-fatty acid cycling in the human newborn: Effect of maternal diabetes and intrauterine growth retardation. Paediatric Res 1992;31:52-8.

  53. Wells JCK, Davies PSW. The components of energy metabolism in 12 week old infants. Ann Hum Biol 1995; 22:175.

  54. Salle B, Ruitton-Uglienco A. Glucose disappearance rate, insulin response and growth hormone response in the small for gestational age and premature infant of very low birth weight. Biol Neonate 1996;29:1-17.

  55. Hay WW Jr. Fetal energy and protein metabolism. Intrauterine Growth Retardation (Editor: Senterre J). Raven Press. New York: 1999. pp. 39-64.

  56. Van den Akker CH, Van Goudoever JB. Recent advances in our understanding of protein and amino acid metabolism in the human fetus. Curr Opin Clin Nutr Metab Care 2010;13:75-80.

  57. Garofano A, Czernichow P, Breant B. Postnatal somatic growth and insulin contents in moderate or severe intrauterine growth retardation in the rat. Biol Neonate 1998;73:89-98.

  58. Lang U, Clark KE. Effects of chronic reduction in uterine blood flow on fetal and placental growth in the sheep. Am J Physiol Regu Integr Comp Physiology 2000;279:53-9.

  59. Peterside I, Selak EM, Simmons RA. Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rat. Am J Physiol Endocrinol Metab 2003;285:1258-66.

  60. Bai B, Yao Y, Li W, Zeng Y, Yang F. The relationships of the serum concentrations of insulin-like growth factors in fetal rats with intrauterine growth retardation. Hua Xi Yi Ke Da Xue Bao 2003;32:307-12.

  61. Bassan H, Rejo N, Kariv M, Bassan M, Berger A, Fatal A et al. Experimental intrauterine growth retardation alters renal development. Pediatr Nephrol 2000;15:192-5.

  62. Merlet-Bénichou C, Gilbert T, Muffat- Joly M, Lelièvre-Pégorier M, Leroy B. Intrauterine growth retardation leads to a permanent nephron deficit in the rat. Pediatr Nephrol 1994;8:175-180.

  63. Filiz S, Dalcik C, Filiz TM, Dalcik H. Localization of neural cell adhesion molecule and pan-cadherin immunoreactivity in intrauterine growth-retarded newborn rats kidneys. Appl. Immunohystochem Mol Morphol 2003; 11:352-8.

  64. Mayhew TM, Gregson MC, Fagan DH. Ventricular myocardium in control and growth-retarded human fetuses: growth in different tissue compartments and variation with fetal weight, gestational age, and ventricle size. Hum Pathol 1999;30:655-60.

  65. Miyague NI, Ghidini A, Fromberg R, Miyague MM. Alterations in ventricular filling in small-for gestational age foetuses. Fetal Diagn Ther 1997;12:332- 5.

  66. Sparks JW, Hay WW Jr, Meschia G, Battaglia FC. Fetal liver metabolism in the unstressed fetal lamb: Experience with a chronic induced hepatic venous catheter. Paediatric Res 1998; 1615: 265A.

  67. Philips AF, Battagha FC. Glucose metabolism and ammonia production by the human placenta in vitro. Paediatric Res 1999;13:117-20.

  68. Lacy JA. Albumin overview: use as nutritional marker and as a therapeutic intervention. Crit Care Nurs 1991;11:46- 9.

  69. Comizio R, Pietrobelli A, Tan YX, Wang ZM, Withers RT, Heymsfi eld SB, Bóxer CN. Total body lipid and triglyceride response to energy deficit: relevance to body composition models. Am J Physiol 1998;274 (Endocrinol Metab 37):E860–E866.

  70. Bastow M. Biochemistry of hospital nutrition. Contemp Issues Clin Biochem 1986;4:123-39.

  71. Shenkin A, Cederblad G, Elia M, Isaksson B. Laboratory assessment of protein energy status. Clin Chim Acta 1996;253:S3-S59.

  72. Kimberly A., Freitag, Kourin E. Acute starvation and subsequent refeeding affect lymphocytes subsets and proliferation in cats. J Nutr 2000;130: 2444-9.

  73. Forbes GB, Bruining GJ. Urinary creatinine excretion and lean body mass. Am J Clin Nutr 1976;29:1359-66.

  74. Avila CG, Harding R, Rees S, Robinson PM. Small intestinal development in growth retarded fetal sheep. J Pediatr Gastroenterol Nutr 1989;8:507-15.

  75. González Sabín C. Funciones intestinales en ratas con crecimiento intrauterino retardado. Instituto Superior de Ciencias Médicas de la Habana. Trabajo de Terminación de Residencia en Fisiología Normal y Patológica. MINSAP Ministerio de Salud Pública. La Habana: 1991.

  76. Bloomfield FH, Bauer MK, Van PL, Gluckman PD, Harding JE. Amniotic IGF-I supplements improve gut growth but reduce circulating IGF-I in growth restricted fetal sheep. Am J Physiol Endocrinol Metab 2002;282:259-69.

  77. Trahair JF, DeBarro TM, Robinson JS, Owens JA. Restriction of nutrition in utero selectively inhibits gastrointestinal growth in fetal sheep. J Nutr 1997;127:637-41.

  78. Lebenthal E, Nitzan M, Lee PC, Chrzanowski BL, Krasner J. Effect of intrauterine growth retardation on the activities of fetal intestinal enzymes in rats. Biol Neonate 1981;39:14–21.

  79. Clarke S, Abraham S. Gene expression. Nutrient control of pretranscriptional and posttranscriptional events. FASEB J 1992;6:3146-52.

  80. Guard J, Hauguel-de Mouzon S, Chatelain F. Regulation of gene expression by nutrients during the perinatal period. En: Placental function and fetal nutrition (Editor: Battaglia FC). Workshop Series 39. Lippincott-Raven. Philadelphia: 1997. pp. 103-121.




2020     |     www.medigraphic.com