Gutiérrez MA, Pardo AB, Gámez MR, Mas FR, García CH, Goicochea CE

Language: Spanish
References: 29
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ABSTRACT

Introduction: finasteride, a specific inhibitor of 5 α-reductase, is used as treatment for benign prostatic hiperplasia. Prenatal exposure to finasteride has proved to inhibit dihydrotestosterone-mediated development and to induce changes that are highly predictive of malformations in the male reproductive tract.
Objective: to confirm the effects caused by finasteride when administered to pregnant rats in the period of sexual differentiation under the laboratory conditions of the Natural Products Center. this is aimed at using it as positive control of damage in reproduction studies.
Methods: pregnant Sprague Dawley rats were gavaged with10 mg/kg/day of finasteride during the gestation days 12 to 21.
Results: significant differences in finasteride treated groups in relation to control group on testis descension were found. In the finasteride-exposed pups there was a significant delay in preputial separation on postnatal day 40 and 45 and all male pups showed females features such as: increased nipple retention (100 %), cleft prepuce (83.9 %) and a decrease in anogenital distance (90.3 %) This was significantly higher than in controls. Besides, 2 animals , 6.5 %, displayed ectopic testes, what was significantly different from controls. Males exposed in utero to finasteride showed atrophy of genital structures, with significant decrease in the relative weights of accessory sexual organ compared to controls.
Conclusions: these results, coherent with the reviewed literature suggest that finasteride provoked alterations on the androgen-dependent response after the exposure in utero and confirmed its validity, as positive control in reproduction studies under our conditions.

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