On anti-lamin B1 autoantibodies  as major determinant  of thromboprotection in SLE patients displaying antiphospholipid antibodies

Arnulfo Nava; Juan Alberto Rodríguez-Ruiz; Gerardo Orozco-López; Gerardo Orozco-Barocio; Ignacio Garcia-de la Torre

2014, Number 1

<< Back

Residente 2014; 9 (1)

On anti-lamin B1 autoantibodies as major determinant of thromboprotection in SLE patients displaying antiphospholipid antibodies

Nava A, Rodriguez-Ruiz JA, Orozco-López G, Orozco-Barocio G, Garcia-de la Torre I

Full text

How to cite this article

Language: English
References: 8
Page: 20-23
PDF size: 243.95 Kb.

ABSTRACT

Autoantibodies directed against components of the nuclear lamina have been initially described using the Western-blot technique. IgG autoantibodies against lamin B1 have been properly identified using an enzymatic immunoassay, mainly in systemic lupus erythematosus (SLE) patients’ sera. It is clear from these works that a subgroup of SLE patients display high titers of autoantibodies against lamin B1 (aLB1), and that those aLB1 were not observed in other rheumatic diseases. In addition, these aLB1 were strongly associated with the lupus anticoagulant. A subsequent exciting finding in a group of 259 SLE patients was the frequency of thrombosis displayed depending on aLB1 and lupus anticoagulant (LAC) status as follows: presence of LAC and abscence of aLB1 50%, presence of both LAC and aLB1 22.7%, abscence of both LAC and aLB1 25.5%, abscence of LAC and presence of aLB1 20.8%. This effect associated with the presence of aLB1 was proposed as a «thromboprotection» and was independent of other antiphospholipid-related antibodies tested such as anticardiolipin and anti-beta(2)GPI. The mechanisms involved in this phenomenon remain to be elucidated, although no evidence was found that supports a direct role of lamin B1 in apoptotic blebs.

REFERENCES

Senecal JL, Raymond Y. Autoantibodies to major and minor nuclear lamins are not restricted to autoimmune diseases. Clin Immunol Immunopathol. 1992; 63 (2): 115-125.
Konstantinov K, von Mikecz A, Buchwald D, Jones J, Gerace L, Tan EM. Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome. J Clin Invest. 1996; 98 (8): 1888-1896.
Senecal JL, Rauch J, Grodzicky T, Raynauld JP, Uthman I, Nava A et al. Strong association of autoantibodies to human nuclear lamin B1 with lupus anticoagulant antibodies in systemic lupus erythematosus. Arthritis Rheum. 1999; 42 (7): 1347-1353.
Dieude M, Senecal JL, Rauch J, Hanly JG, Fortin P, Brassard N et al. Association of autoantibodies to nuclear lamin B1 with thromboprotection in systemic lupus erythematosus: lack of evidence for a direct role of lamin B1 in apoptotic blebs. Arthritis Rheum. 2002; 46 (10): 2695-2707.
Butin-Israeli V, Adam SA, Goldman RD. Regulation of nucleotide excision repair by nuclear lamin b1. PLoS One. 2013; 8 (7): e69169. doi: 10.1371/journal.pone.0069169. Print 2013. PubMed PMID: 23894423; PubMed Central PMCID: PMC3722182.
Wang Y, Azuma Y, Friedman DB, Coffey RJ, Neufeld KL. Novel association of APC with intermediate filaments identified using a new versatile APC antibody. BMC Cell Biol. 2009; 10: 75. doi: 10.1186/1471-2121-10-75. PubMed PMID: 19845967; PubMed Central PMCID: PMC2774295.
Tang CW, Maya-Mendoza A, Martin C, Zeng K, Chen S, Feret D et al. The integrity of a lamin-B1-dependent nucleoskeleton is a fundamental determinant of RNA synthesis in human cells. J Cell Sci. 2008; 121 (Pt 7): 1014-1024. doi: 10.1242/jcs.020982. Epub 2008 Mar 11. PubMed PMID: 18334554.
Moisan E, Girard D. Cell surface expression of intermediate filament proteins vimentin and lamin B1 in human neutrophil spontaneous apoptosis. J Leukoc Biol. 2006; 79 (3): 489-498. Epub 2005 Dec 19. PubMed PMID: 16365157.