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2014, Number 1

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Rev Esp Med Quir 2014; 19 (1)

Glial-derived neurotrophic factor: a therapeutic promise for Parkinson’s disease

Piña LC, Lara LM, Moreno SHN, Merino GJL, Thompson BMR, Rosas SG, Calderón RG, Rangel GPSI, Morán MPE, Rodríguez GJ, González BJA

Language: Spanish
References: 40
Page: 88-95
PDF size: 1093.35 Kb.


ABSTRACT

Glial derivate neurotrophic factor (GDNF) constitutes a strong cellular trophic factor that promotes survival, maintenance and restoration of dopaminergic neurons in the mature central nervous system. These properties have supported the idea of co-administering GDNF and conventional pharmacological treatment of Parkinson’s disease (PD), since the etiology of this pathology is characterized by the progressive loss of dopaminergic neurons that provide innervations to basal ganglia, affecting the control of motor functions. Although conventional treatment with L-DOPA and cellular transplants (fetal dopaminergic neurons or differentiated chromafin cells) have been helpful to increase the dopaminergic transmission and control disabling PD symptoms, these treatments have failed to stop the progressive cell degeneration. Consequently, current research efforts in neuroscience are aimed to find such trophic factors that help to stop the progressive cell destruction and facilitate the survival of dopaminergic neurons, as well as the increase of the functional activity of the remaining dopamine neurons.


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