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2013, Number 3

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Rev Cubana Invest Bioméd 2013; 32 (3)

Characterization of the association between atherosclerosis and osteoporosis in men and women: study of deceased subjects

Solís AL, Fernández-Britto RJE, Bacallao GJ

Language: Spanish
References: 38
Page: 321-337
PDF size: 354.97 Kb.


ABSTRACT

Objectives: characterize the association between atherosclerotic lesions of the coronary arteries and osteoporosis of the lumbar spine and the proximal femur in men and women.
Methods: a study was conducted of 79 necropsies by postmortem densitometry of the lumbar spine and proximal femur. Bone mineral density (BMD) levels were classified according to T score into normal, osteopenia and osteoporosis; followed by pathomorphological and morphometric examination of the three major epicardial coronary arteries, applying the atherometric system and classifying the atherosclerotic lesions into adipose stria, fibrous plate and grave plate.
Results: the association between atherosclerosis and osteoporosis exhibited specific features for each sex, with a significant predominance of osteoporosis in men and osteopenia in women. After removing the effect of cigarette smoking, there was a change in the differences between the sexes, with smokers of both sexes presenting a similar BMD and a similar association between atherosclerosis and osteoporosis.
Conclusions: the influence of sex upon the association between atherosclerosis and osteoporosis was negligible.


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