2013, Number 4
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Revista Cubana de Cirugía 2013; 52 (4)
Liver transplantation, biliary anastomosis technique and complications observed in 10 year-work
Argüelles PO, Díaz MJ, Collera RS
Language: Spanish
References: 53
Page: 257-270
PDF size: 84.40 Kb.
ABSTRACT
Introduction: The liver transplantation is indicated in those hepatic diseases for which it is not possible to use other therapeutic measures (or they have failed), and the expected survival rate or the quality of life of the patient is lower than the expected from liver transplantation, provided that there is no contraindications for transplantation. Traditionally, choledocho-choledocho termino-terminal anastomosis used to be performed with separate points over the Kehr tube placed at the receptor choledocho and tutoring anastomosis.
Objectives: To determine the complications related to principal biliary tract repair and to define the relationship of the biliary anastomosis technique and the diagnosed biliary complications after transplantation.
Methods: A retrospective observational, descriptive and longitudinal study was conducted to characterize the biliary complications in liver transplantation. All the medical records of the patients, who underwent this procedure during the 1999-2009 period, were checked. Absolute and relative frequencies and summary measures for quantitative variables were used.
Results: Stenosis was more frequently diagnosed in patients with termino-terminal anastomosis with tutor, accounting for 50%. Abdominal pain and icterus were the predominant symptoms and signs. Of the transplanted patients, 65.8% presented with some type of biliary complications. Thirteen of them (34.2%) had unfavorable progression and 8 died.
Conclusions: Biliary tract is undoubtedly the technical aspect with highest morbimortality in transplanted patients, led by stenosis. The used technique is highly influential in this regard, icterus and pain are alarming signs to be considered for diagnosis, being retrograde endoscopic cholangiopancretography the real solution for many patients.
REFERENCES
Murray KF, Carithers RL. AASLD practice guidelines: evaluation of the patient for liver transplantation. Hepatology 2005; 41: 1407-32.
Prieto M, Clemente G, Casafont F, Cuende N, Cuervas-Mons V, Figueras J et al. Documento de consenso de indicaciones de trasplante hepático. Gastroenterol Hepatol 2003; 26: 355-375.
Organización Nacional de trasplante (ONT) Agencia de evaluación de tecnologías sanitarias (AETS). Indicaciones y contraindicaciones del trasplante y retrasplante hepático. Madrid.1995.
Pretejo Pastor V, Sala Feliz T. Tumores y estenosis del árbol biliar en Tratamiento de las enfermedades gastroenterológicas. Asociación Española de gastroenterología. Ediciones Doyma. S: L: Barcelona.2006
Carlos Chan, Juan j. Pérez Muñoz, Bernardo Franssen. Técnicas quirúrgicas en trasplante hepático. Revista de investigación clínica. 2005; 57(2): 262-72.
De la Rosa G. Séptima memoria de resultados del Registro Español de Trasplante Hepático (1984-2004).2004; 23: 236-53.
J.I herrero, J. Quiroga, F. Pardo. El trasplante hepático en el año 2000. Anales.2000; 57: 198-226.
Rerknimitr R, Sherman S, Fogel EL, et al. Biliary tract complications after orthotopic liver transplantation with choledochocholedochostomy anastomosis: endoscopic findings and results of therapy. Gastrointest Endosc 2002; 55:224-31.
Sherman S, Jamidar P, Shaked A, et al. Biliary tract complications after orthotopic liver transplantation: endoscopic approach to diagnosis and therapy. Transplantation 1995; 60:467-70.
Gholson CF, Zibari G, McDonald JC. Endoscopic diagnosis and management of biliary complications following orthotopic liver transplantation.Dig Dis Sci 1996; 41:1045-53.
Gonzalez Rapado L. primer trasplante ortotopico con supervivencia en Cuba. Rev.Cub. Cirug. 1989 28:101-23.
Herrero JI, Sangro B, Quiroga J, Pardo F, Herrazaim, Cienfuegos JA, Prieto J. Influence of tumor characteristics on the outcome of liver transplantation among patients with liver cirrhosis and hepatocellular carcinoma.Liver Transpl 2001; 7: 631-636.
Bruix J, Llovet JM. Prognostic prediction and treatment strategy in hepatocellularcarcinoma. Hepatology 2002; 35: 519-524.
Hassounz Z, Gores GJ, Rosen CB. Preliminary experience with liver transplantation in selected patients with unresectable hilar cholangiocarcinoma. Surg Oncol Clin N Am 2002; 11: 909-921.
Fung J, Eghtesad B, Patel-Tom K, Devera M, Chapman H, Ragni M. Liver transplantation in patients with HIV infection. Liver Transpl 2004; 10 (10 Suppl 2): S39-53.
Alsharabi A, Zienewicz K, Patkwoski W, Wroblewski T, Grzelak I, Michalowicz B. Assessment of early biliary complications after ortothopic liver transplantation and their relationship to the technique of the biliary reconstruction. Transplant Proc. 2006. Jan Feb; 38(1):244-6.
Soria Aledo V, Carrasco Prats, M, Parrilla Paricio P. Complicaciones relacionadas con el tubo en T en cirugía biliar. Cir. Esp 2004; 68: 486-492.
Robles R, Parrilla P, Sanchez Bueno F, Acosta F, Ramírez P, Rodríguez JFet al. La peritonitis biliar tras retirar el tubo de Kehr en pacientes con trasplante ortotópico hepático es más frecuente que en pacientes con litiasis biliar. Cir. Esp 1993; 53:269-270.
Krowka MJ, Plevak DJ, Findlay JY, Rosen CB, Wiesner RH, Krom RA. Pulmonary hemodynamics and perioperative cardiopulmonaryrelated mortality in patients with portopulmonary hypertension undergoing liver transplantation. Liver Transpl 2000; 6: 443- 450.
O'carrol RE, Couston M, Cossar J, Masterton G, Hayes PC. Psychological outcome and quality of life following liver transplantation: a prospective, national, single-center study. Liver Transpl 2003; 9: 712-720.
Fondevila C, Ghobrial RM. Donor selection and management. En: Busuttill and Klintmalm (Eds.) Transplantation of the liver, second edition. Elsevier, Philadelphia 2005:515-528.
Herrero JI, Lucena JF, Quiroga J, Sangro B, Pardo F, Rotellar F et al. Liver transplant recipients older than 60 years have lower survival and higher incidence of malignancy. Am J Transplant 2003; 3: 1407-1412.
Cuende N, Grande L, San Juan F, Cuervas-Mons V. Liver transplant with organs from elderly donors: Spanish experience with more than 300 liver donors over 70 years of age. Transplantation 2005; 73: 1360.
Muiesan P, Girlanda R, Jassem W, Melendez HV, O'grady J, Bowles M et al. Single-center experience with liver transplantation from controlled non-heartbeating donors: aviable source of grafts. Ann Surg 2005; 242:732-738.
Nair S, Verma S, Thuluvat PJ. Pretransplant renal function predicts survival in patients undergoing orthotopic liver transplantation. Hepatology 2004; 35: 1179-1185.
Kim WR, Poterucha JJ, Kremers WK, Ishitani MB, Dickson ER. Outcome of liver transplantationfor hepatitis B in the United States.Liver Transpl 2004; 10: 968-974.
Berenguer M, Prieto M, San Juan F, Rayon JM, Martinez F, Carrasco D et al. Contribution of donor age to the recent decrease in patient survival among HCV-infected liver transplant recipients. Hepatology 2002; 36: 202-210.
Herrero JI. Neoplasias postrasplante: estrategias de vigilancia y diagnóstico temprano. Gastroenterol Hepatol 2006; 29 (Supl.1): 75-80.
Herrero JI, Lorenzo M, Quiroga J, Sangro B, Pardo F, Rotellar F et al. De Novo neoplasia after liver transplantation: an analysis of risk factors and influence on survival. Liver Transpl 2005; 11: 89-97.
Herrero JI, Espana A, Quiroga J, Sangro B, Pardo F, Alvarez-Cienfuegos J et al. Nonmelanoma skin cancer after liver transplantation. Study of risk factors. Liver Transp. 2005; 11: 1100-6.
Bourgeois N, Deviere J, Yeaton P, et al. Diagnostic and therapeutic endoscopic retrograde cholangiography after liver transplantation. Gastrointest Endosc 1995;42:527-34.
Rey JF, Dumas R, Canard JM, et al. French Society of Digestive Endoscopy. Guidelines of the French Society of Digestive Endoscopy: biliary stenting. Endoscopy 2002; 34:169-73.
Ostroff JW, Roberts, JP, Gordon RL, Ring, EJ, Ascher NL. The managent of T tube le asks in orthotropic liver transplant recipients with endoscopically placed nasobiliary catheters transplantation 1990; 49:922 954.
Ranbkin JM, Orloff SL, Reed MH, et al. Biliary tract complications of side to side without a T tube versus end-to-end with or without T tube choledococholedocostomy in liver transplantrecipients. Transpl 1998; 65: 193-9.
Goff JS. Common bile duct sphincter of Oddi stenting in patients with suspected sphincter dysfunction. Am J Gastroenterol 1995; 90:586-9?
Thuluvat PJ. When is diabetes mellitus a relative or absolute contraindication to liver transplantation? Liver Transpl 2005; 11 (11 Suppl 2): S25-29.
Nair S, Verma S, Thuluvat PJ. Obesity and its effect on survival in patients undergoing orthotopic liver transplantation in the United States. Hepatology. 2002; 35: 105-109.
Arenas JI, Vargas HE, RakelaA J. The use of hepatitis C-infected grafts in liver transplantation. Liver Transpl 2004; 9: S48-51.
O'Grady JG, Alexander GJ, Hayllar KM, Williams R. Early indicators of prognosis in fulminant hepatic failure. Gastroenterology1989; 97: 439-445.
Elola-Olaso AM, Diaz IC, Glez EM, Garcia Garcia I. Preliminary study of choledochocholedochostomy without T tube in liver transplantation: A comparative study. Transplant Proc. 2005. Nov; 37(9):3922-3.
Pfau PR, Kochman ML, Lewis JD, et al. Endoscopic management of postoperative biliary complications in orthotopic liver transplantation. Gastrointest Endosc 2000; 52:55-63.
Park JS, Kim MH, Lee SK, et al. Efficacy of endoscopic and percutaneous treatments for biliary complications after cadaveric and living donor liver transplantation. Gastrointest Endosc 2003; 57:78-85.
Mahajani RV, Cotler SJ, Uzer MF. Efficacy of endoscopic management of anastomotic biliary strictures after hepatic transplantation. Endoscopy 2000;32:943-9.
Thuluvath PJ, Atassi T, Lee J. An endoscopic approach to biliary complications following orthotopic liver transplantation. Liver Int 2004; 23:156-62.
Morelli J, Mulcahy HE, Willner IR, et al. Long-term outcomes for patients with post-liver transplant anastomotic biliary strictures treated by endoscopic stent placement. Gastrointest Endosc 2003; 58: 374-9.
Morelli J, Mulcahy HE, Willner IR, et al. Endoscopic treatment of postliver transplantation biliary leaks with stent placement across the leak site. Gastrointest Endosc 2001; 54:471-5.
Bueno J, Gerdes H, Kurtz R. Endoscopic management of occluded biliary Wallstents: a cancer center experience. Gastrointest Endosc 2003; 58:879-84.
Bhattacharjya S, Puleston J, Davidson BR, et al. Outcome of early endoscopic biliary drainage in the management of bile leaks after hepatic resection. Gastrointest Endosc 2004;57:526-30.
Levy M, Baron T, Gostout J, et al. Palliation of malignant extrahepatic biliary obstruction with liver transplantation. Clin Gastroenterol Hepatol 2004; 2:273-85.
Prieto M, Gomez MD, Berenger M, Cordoba J, Rayon JM, Pastor M et al. De novo hepatitis B after liver transplantation from hepatitis B core antibody-positive donors in an area with high prevalence of anti-HBc positivity in the donor population. Liver Transpl 2001;7: 51-58.
Rizk RS, McVicar JP, Emond MJ, et al. Endoscopic management of biliary strictures in liver transplant recipients: effect on patient and graft survival. Gastrointest Endosc 1998; 47:128-35.
Rossi AF, Grosso C, Zanasi G, et al. Long-term efficacy of endoscopic stenting in patients with stricture of the biliary anastomosis after orthotopic liver transplantation. Endoscopy 1998; 30:360-6.
OPTN/SRTR 2009 Annual Report. Adjusted patient survival, deceased donor liver transplant survival at 3 months, 1 year, 3 years and 5 years. [on line]. [consultado: 12 de enero de 2013]. Disponible en: http://www.ustransplant.org/annual_reports/current/911a_li.pdf .