medigraphic.com
Instituto Nacional de Neurología y Neurocirugía

2013, Number s1

Next >>

Arch Neurocien 2013; 18 (s1)

Diabetes mellitus and its association whit dementia and mild cognitive impairment in elderly mexican urban and rural population

Salinas-Contreras RM, Hiriart-Urdanivia M, Acosta-Castillo I, Sosa-Ortiz AL

Language: Spanish
References: 36
Page: 1-7
PDF size: 161.18 Kb.


ABSTRACT

Diabetes mellitus type 2 (DM2) has been associated with an increased risk of mild cognitive impairment (MCI) and dementia. The DM2 is associated with other risk factors for dementia, such as age, hypertension, hypercholesterolemia, obesity and depression. Considering the high prevalence of DM2 is important to assess whether this condition represents a risk in older Mexican to develop dementia because both threaten to substantially increased as a result of population aging. Objective: to evaluate the association of DM2 with the presence of MCI or dementia in older Mexican of urban and rural areas. Method: study of fixed cohort tracking in subjects living in urban and rural areas without dementia followed for three years. The total sample of 1,194 subjects over 65 years. DM2 was diagnosed according to the criteria of the American Diabetes Association, MCI according to the Petersen´s criteria of and dementia according to DSMIV criteria and the algorithm 10/66. Results: the incidence rate of dementia in subjects with DM2 was 0.029, the incidence rate of MCI in subjects with DM2 was 0.018. Subjects with DM2 had 1.87 times the risk of developing dementia than those without DM2 (HR 1.87, CI 1.2-2.7). On the other hand, we found no statistically significant association with the development of MCI in subjects with DM2. Conclusions: subjects with type 2 diabetes mellitus are at increased risk of developing cognitive impairment but not dementia.


REFERENCES

  1. Uzun S, Kozumplik O, Folnegovi Folnegovic-Smalc V. Alzheimer´s dementia: current Data Review. Coll Antropol 2011;35(4):1333-7.

  2. Pichot P, Aliño JJL-I, Miyar MV. DSM-IV Manual diagnóstico y estadístico de los trastornos mentales. 1995.

  3. ADI. World Alzheimer Report. London, UK: Alzheimer’s disease International, 2009.

  4. Etgen T, Sander D, Bickel H, Forstl H. Mild cognitive impairment and dementia: the importance of modifiable risk factors. Dtsch Arztebl Int 2011;108(44):743-50. PubMed PMID: 22163250. Pubmed Central PMCID: 3226957. Epub 2011/12/14. Eng.

  5. Cheng G, Huang C, Deng H, Wang H. Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J 2012 May;42(5):484-91. PubMed PMID: 22372522. Epub 2012/03/01. Eng.

  6. Kopf D, Frolich L. Risk of incident Alzheimer’s disease in diabetic patients: a systematic review of prospective trials. J Alzheimer’s disease: JAD. 2009;16(4):677-85. PubMed PMID: 19387104.

  7. Profenno LA, Porsteinsson AP, Faraone SV. Meta-analyssis of Alzheimer’s disease risk with obesity, diabetes, and related disorders. Biological psychiatry 2010 Mar 15;67(6):505-12. PubMed PMID: 19358976.

  8. Vagelatos NT, Eslick GD. Type 2 diabetes as a risk factor for alzheimer’s disease: the confounders, interactions, and neuropathology associated with this relationship. Epidemiol Rev 2013; 21. PubMed PMID: 23314404. Epub 2013/01/15. Eng.

  9. Xu W, Caracciolo B, Wang HX, Winblad B, Backman L, Qiu C, et al. Accelerated progression from mild cognitive impairment to dementia in people with diabetes. Diabetes. 2010; 59(11):2928-35. PubMed PMID: 20713684. Pubmed Central PMCID: 2963552.

  10. Ohara T, Doi Y, Ninomiya T, Hirakawa Y, Hata J, Iwaki T, et al. Glucose tolerance status and risk of dementia in the community: the Hisayama study. Neurol 2011; 20;77(12)1126-34. PubMed PMID: 21931106.

  11. Mejia-Arango S, Zuniga-Gil C. Diabetes mellitus as a risk factor for dementia in the Mexican elder population. Rev Neurol 2011; 1;53(7)397-405. PubMed PMID: 21948010. Pubmed Central PMCID: 3557520. Diabetes mellitus como factor de riesgo de demencia en la poblacion adulta mayor mexicana.

  12. Hassing LB, Johansson B, Nilsson SE, Berg S, Pedersen NL, Gatz M, et al. Diabetes mellitus is a risk factor for vascular dementia, but not for Alzheimer’s disease: a population-based study of the oldest old. International psychogeriatrics / IPA. 2002;14(3):239-48. PubMed PMID: 12475085.

  13. Hayden KM, Zandi PP, Lyketsos CG, Khachaturian AS, Bastian LA, Charoonruk G, et al. Vascular risk factors for incident Alzheimer disease and vascular dementia: the cache county study. Alzheimer disease and associated disorders. 2006; 20(2):93-100. PubMed PMID: 16772744.

  14. Kimm H, Lee PH, Shin YJ, Park KS, Jo J, Lee Y, et al. Mid-life and late-life vascular risk factors and dementia in Korean men and women. Archives of Gerontology and Geriatrics 2011; 52(3):e117-22. PubMed PMID: 20932588.

  15. Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran- Sacrey D, et al. The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals eith mild cognitive impairment. Am J Geriatric Psychiatry: official Journal of the American Association for Geriatric Psychiatry 2013;6. PubMed PMID: 23567388.

  16. Arrighi HM, Gelinas I, McLaughlin TP, Buchanan J, Gauthier S. Longitudinal changes in functional disability in Alzheimer’s Vol. 18 | Suplemento I 2013 | 7 Rosa María Salinas-Contreras, et al Arch Neurocien (Mex) Vol 18, Supl-I, 1-7, 2013 disease patients. International Psychogeriatrics / IPA 2013;25 (6):929-37. PubMed PMID: 23406898.

  17. De la Roca-Chiapas JM, Hernandez-Gonzalez M, Candelario M, Villafana Mde L, Hernandez E, et al. Association between depression and higher glucose levels in middle-aged Mexican patients with diabetes. Revista de investigacion clínica; órgano del Hospital de Enfermedades de la Nutrición. 2013;65(3):209- 13. PubMed PMID: 23877807.

  18. Prince M, Ferri CP, Acosta D, Albanese E, Arizaga R, Dewey M, et al. The protocols for the 10/66 dementia research group population-based research programme. BMC public health. 2007;7:165. PubMed PMID: 17659078. Pubmed Central PMCID: 1965476.

  19. ADA. American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes care. 2013;36 Suppl 1:S67-74. PubMed PMID: 23264425. Pubmed Central PMCID: 3537273.

  20. Lorenzo C, Williams K, Hunt KJ, Haffner SM. The National Cholesterol Education Program - Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes. Diabetes Care 2007;30(1):8-13. PubMed PMID: 17192325.

  21. Quetelet LAJ. Anthropométrie uo mesure des différentes facultés de I´homme. Bruxelles1870.

  22. Aguilar-Navarro SG, Reyes-Guerrero J, Borgues G. Cognitive impairment and alcohol and cigarette consumption in Mexican adults older than 65 years. Salud Pública de México. 2007;49 Suppl 4:S467-74. PubMed PMID: 17724519. Alcohol, tabaco y deterioro cognoscitivo en adultos mexicanos mayores de 65 años.

  23. APA. Diagnostic and Statistical Manual of Mental Disorders 4th. Text revision. Washington,DC. American Psychiatric Association 2000.

  24. WHO. International Statistical Classification of Diseases and Related Health Problems 10th. 10th ed. Ginebra: World Health Organization; 1992.

  25. Copeland JR, Dewey ME, Griffiths-Jones HM. A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychol Med 1986; 16(1):89-99. PubMed PMID: 3515380. Epub 1986/02/01. eng.

  26. Ustun TB, Chatterji S, Kostanjsek N, Rehm J, Kennedy C, Epping-Jordan J, et al. Developing the World Health Organization Disability Assessment Schedule 2.0. Bulletin of the World Health Organization. 2010;1;88(11):815-23. PubMed PMID: 21076562. Pubmed Central PMCID: 2971503.

  27. Prince M, Acosta D, Chiu H, Scazufca M, Varghese M, Dementia Research G. Dementia diagnosis in developing countries: a cross-cultural validation study. Lancet 2003; 15;361(9361):909-17. PubMed PMID: 12648969.

  28. Petersen RC, Stevens JC, Ganguli M, Tangalos EG, Cummings JL, DeKosky ST. Practice parameter: early detection of dementia: mild cognitive impairment (an evidence- based review). Report of the quality standards subcommittee of the american academy of neurology. Neurology 2001;8;56(9): 1133-42. PubMed PMID: 11342677.

  29. IBM-Corp. IBM SPSS Statistics for Windows (version 19.0). Armonk, NY: IBM Corp.; 2010.

  30. Stata Statistical Sofware: Release 10.1. ed.: Stata Corp (Database on internet). 2007.

  31. Vagelatos NT, Eslick GD. Type 2 diabetes as a risk factor for Alzheimer´s disease: The confunders, interactions, and neuropathology associated with this relationship. Epidemiol Rev 2013;35:152-60.

  32. Schrijvers EM, Witteman JC, Sijbrands EJ, Hofman A, Koudstaal PJ, Breteler MM. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study. Neurology 2010; 30;75(22):1982-7. PubMed PMID: 21115952. Pubmed Central PMCID:3014236.

  33. Toro P, Schonknecht P, Schroder J. Type II diabetes in mild cognitive impairment and Alzheimer’s disease: results from a prospective population-based study in Germany. J Alzheimer’s disease: JAD. 2009;16(4):687-91. PubMed PMID: 19387105.

  34. Xu WL, Qiu CX, Wahlin A, Winblad B, Fratiglioni L. Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6- year follow-up study. Neurology 2004;12:63(7)1181-6. PubMed PMID: 15477535.

  35. Starr VL, Convit A. Diabetes, sugar-coated but harmful to the brain. Current Opinion in Pharmacology 2007;7(6)638-42. PubMed PMID: 18024186. Pubmed Central PMCID: 2170066.

  36. Umegaki H. Neurodegeneration in diabetes mellitus. In: Ahmad SI, editor. Neurodegenerative Dis 2012; 258-65.




2020     |     www.medigraphic.com