2013, Number 4
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Rev Cub Med Mil 2013; 42 (4)
Metabolic syndrome in children and adolescents
Alpízar CLB
Language: Spanish
References: 30
Page: 464-471
PDF size: 44.06 Kb.
ABSTRACT
A bibliographic review was conducted of the topic of metabolic syndrome in children and adolescents with the purpose of describing key elements showing the importance of detecting and controlling risk factors in childhood to ensure good health in adulthood. The review was based on databases such as Lilacs, BVS-BIREME, Hinari, Pubmed and Scielo. It was found that metabolic syndrome is a multifactorial problem combining environmental and genetic factors. The presence of this condition in youth directly affects quality of life in adulthood. Early identification of risk factors in young ages could be a first step in the prevention of future complications. The key to success largely lies in preventing obesity and fostering appropriate lifestyles. It follows from these results that modifying those factors in adolescence would be an important step toward reducing the prevalence of chronic diseases such as obesity, diabetes mellitus, arterial hypertension and stroke.
REFERENCES
Reaven G. Banting lecture: Role of insulin resistance in human disease. Diabetes. 1988;37:1595-607.
Meigs JB, D'Agostino RB, Wilson PW, Cupples LA, Nathan DM, Singer DE. Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study. Diabetes. 1997;46:1594-1600.
Lee J, Sparrow D, Vokonas P, Landsberg L, Weiss ST. Uric acid coronary heart disease risk: Evidence for a role of uric acid in the obesity-insulin resistance syndrome. The Normative Aging Study. Am J Epidemiol. 1995;142:288-94.
Weiss R, Dziura J, Burgert T, Tamborlane W, Taksali S, Yeckel C, et al. Obesity and the Metabolic Syndrome in Children and Adolescents. N Engl J Med. 2004;350:2362-74.
Nygard O, Vollset S, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, et al. Total homocysteine and cardiovascular disease. J Intern Med. 1999;246:425-54.
Hotamiligil G, Spiegelman B. Tumor necrosis factor alpha: A key component of the obesity-diabetes link. Diabetes. 1994;43:1271-8.
Campos M, Cañete R, Villada I, Linde J, Ramírez-Tortosa MC, Gil A. Relaciones de la adiponectina con la resistencia insulínica, lípidos plasmáticos y TNF-alfa, en el niño obeso prepúber. An Pediatr. 2004;60(Supl 2):153.
Ceballos LT. Síndrome metabólico en la infancia. An Pediatr (Barc). 2007;66(2):159-66.
Arpa A, González O, Vega C. Hábitos y estilos de vida asociados al síndrome metabólico. Rev Cubana Med Milit. 2010;39(1):16-26. 9. Ekelund U, Brage S, Froberg K. TV Viewing and Physical Activity Are Independently Associated with Metabolic Risk in Children: The European Youth Heart Study. PLoS Med. 2006;3(12):e488.
Pei-Chia Chang, Tsai-Chung Li, Ming-Tsang Wu. Association between television viewing and the risk of metabolic syndrome in a community-based population. BMC Public Health. 2008;8:93.
Marshall SJ, Biddle SJ, Gorely T. Relationships between media use, body fatness and physical activity in children and youth: A meta-analysis. Int J Obes Relat Metab Disord. 2004;28:1238-46.
Hancox RJ, Milne BJ, Poulton R. Association between child and adolescent television viewing and adult health: A longitudinal birth cohort study. Lancet. 2004;364:257-62.
Berkey CS, Rockett HR, Gillman MW, Colditz GA. One-year changes in activity and in inactivity among 10- to 15-year-old boys and girls: Relationship to change in body mass index. Pediatrics. 2003;111:836-43.
Mills GW, Avery P, McCarthy M, Hattersley AT, Levy JC, Hitman GA, et al. Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes. Diabetologia. 2004;47:732-8.
Srinivasan S, Myers L, Berenson G. Predictability of childhood adiposity and insulin for developing insulin resistance syndrome (syndrome X) in young adulthood: The Bogalusa Heart Sudy. Diabetes. 2002;51:204-9.
Wabitsch M. Overweight and obesity in European children: Definition and diagnosis procedures, risk factors and consequences for later health outcome. Eur J Pediatr. 2000;159(Suppl 1):8-13.
Ryder E. Una epidemia global: el síndrome metabólico. An Venez Nutr. 2005;18(1):105-9.
Kohen-Avramoglua R, Theriaultb A, Khosrow A. Metabolic syndrome in childhood: An epidemiological overview and mechanistic link to dyslipidemia. Clin Biochem. 2003;36:413-20.
Rodríguez A, Sánchez M, Martínez L. Síndrome metabólico. Rev Cubana Endocrinol. 2002;13:238-52.
Decsi T, Molnar D. Insulin resistance syndrome in children. Pediatr Drugs. 2003;5:291-9.
Ferannini E, Mari A. How to measure insulin sensitivity. J Hypertens. 1998;16:895-906.
Calderín RO, Prieto M, Cabrera E. Síndrome de insulinorresistencia en niños y adolescentes. Rev Cubana Endocrinol Internet]. 2007 [citado 15 Feb 2011];18(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1561-29532007000200007&lng=es&nrm=iso&tlng=es
Raitakari O, Porkka K, Rasanen L, Ronnemaa T, ViiKari J. Clustering and six years cluster-tracking of serum total cholesterol, HDL-cholesterol an diastolic blood pressure in children and young adults. The Cardiovascular Risk in Youngs Finns Study. J Clin Epidemiol. 1994;47:1085-93.
Bao W, Srinivasan S, Wattigney W, Berenson G. Persistence of multiple cardiovascular risk related to syndrome X from childhood to young adulthood. Arch Intern Med. 1994;154:1842-7.
Katzmarzyk P, Perusse L, Malina R, Bergeron J, Despres J, Bouchard C. Stability of indicators of metabolic syndrome from chilhood and adolescence to young adult: the Quebec Family Study. J Clin Epidemiol. 2001;54:190-5.
Maffeis C, Pietrobelli A, Grezzani A, Provera S, Tato L. Waist circumference and cardiovascular risk factors in prepuberal children. Obes Res. 2001;9:179-87.
Savva S, Tornaritis M, Savva M, Kourides Y, Panagi A, Silikiotou N, et al. Waist circumference and waist-to-height ratio are better predictors of cardiovascular disease risk factors in children than body mass index. Int J Obes Relat Metab Disord. 2000;24:1453-8.
Kay JP, Alemzadeh R, Langley G, D'Angelo L, Smith P, Holshouser S. Beneficial effects of metformin in normoglucemic morbidly obese adolescents. Metabolism. 2001;50:1457-61.
Miyazeki Y, Mahonkali A, Matsuda M, Mahankali S, Hardies J, Cusi K, et al. Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patient. J Clin Endocrinol Metab. 2002;87:2784-91.
Wiegman A, Hutten BA, De Groot E, Rodenburg J, Bakker HD, Buller HR, et al. Efficacy an safety of statin therapy in children with familial hypercholesterolemia: A randomized contolled trial. JAMA. 2004;292:331-7.