2014, Number 01
<< Back Next >>
MediSan 2014; 18 (01)
Nesidioblastosis: persistent hyperinsulinemic hypoglycemia in the childhood
Granela CK, Gutierrez MA, Medina AFE, Montesinos ET, Perón RD
Language: Spanish
References: 10
Page: 127-133
PDF size: 260.73 Kb.
ABSTRACT
Two case reports of female newborns are presented who, among other symptoms,
presented with low concentrations of maintained glucemia (lower than 2,2 mmol/L), so
they were evaluated in the Endocrinology Service of "Eduardo Agramonte Piña" Teaching
Pediatric Provincial Hospital in Camagüey, where they were diagnosed nesidioblastosis--
persistent neonatal hypoglycemia --. In one of the patients the medical treatment was
favorable, but in the other it was necessary to carry out a subtotal pancreatectomy. At
present both patients receive therapeutic schedules adjusted to their clinical needs.
REFERENCES
Laidlaw GF. Nesidioblastoma, the islet tumor of the pancreas. Am J Path. 1938; 14(2): 125-34.
Raffel A, Krausch MM, Anlauf M, Wieben D, Braunstein S, Klöppel G, et al. Diffuse nesidioblastosis as a cause of hyperinsulinemic hypoglycemia in adults: a diagnostic and therapeutic challenge. Surgery. 2007; 141(2): 179–84.
Speranza N, Telechea H, Giachetto G, Pírez MC. Hiperinsulinismo congénito: revisión de aspectos diagnósticos y terapéuticos a propósito de un caso clínico. Arch Pediatr Urug. 2008 [citado 6 Mar 2013]; 79(3). Disponible en: http://www.scielo.edu.uy/ scielo.php?pid=S0004-05842008000300005 &script=sci_arttext
Zaldívar Ochoa JR, Rodríguez Carballo A, Quesada Cortés M, Martínez Álvarez M, Santiago Oconnor A, Menéndez Rodríguez M. Nesidioblastosis: hipoglucemia hiperinsulínica persistente en un recién nacido. MEDISAN. 2012 [citado 6 Mar 2013]; 16(12). Disponible en: http://scielo.sld.cu/scielo.php?pid=S1029-301920120012000 19&script=sci_arttext
Arnoux JB, de Lonlay P, Ribeiro MJ, Hussain K, Blankenstein O, Mohnike K, et al. Congenital hyperinsulinism. Early Hum Dev. 2010; 86(5): 287-94.
Flanagan SE, Kapoor RR, Banerjee I, Hall C, Smith W, Hussain K, et al. Dominantly acting ABCC8 mutations in patients with medically unresponsive hyperinsulinaemic hypoglycaemia. Clin Genet. 2011; 79(6): 582-7.
Carvajal Martínez F, Montesino Estévez T, Pérez Gesen C, Perón Rodríguez D, Rodríguez Gómez O, Soto Agüero L, et al. Enfermedad endocrino-quirúrgica pancreática en la infancia: presentación de 4 pacientes. Rev Cubana Endocrinol. 1998; 9(3): 221-8.
Nasir AM, Jurayyan A. Spectrum of endocrine disorders at the Paediatric Endocrine Clinic, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia. Journal of Taibah University Medical Sciences. 2012; 7(2): 99–103.
García Domínguez AM, Ramírez Mora JC. Manejo anestésico de hipoglucemia hiperinsulinémica persistente en niños del Hospital Infantil de México “Federico Gómez”. Serie de casos. Rev Mex Anest. 2009; 32(3): 196-200.
Kapoor RR, Flanagan SE, James C, Shield J, Ellard S, Hussain K. Hyperinsulinaemic hypoglycaemia. Arch Dis Child. 2009; 94(6): 450-7.