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2013, Number S1

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Evid Med Invest Salud 2013; 6 (S1)

Implications of ischemia-reperfusion injury in organ transplants

Casillas-Ramírez A, Cavazos-Velázquez JS, Meza-Martínez DY, De la Garza-De León JR

Language: Spanish
References: 32
Page: 5-11
PDF size: 352.82 Kb.


ABSTRACT

The excellent results that have been obtained in the transplantation of various organs have resulted in an increase in the number of terminally ill patients seeking this surgical treatment. While there have been important advances that have placed this procedure as a routine technique in clinical practice, the ischemia-reperfusion injury inherent in every organ transplantation remains an unsolved problem. Ischemia-reperfusion injury refers to tissue damage caused when blood flow returns to an organ following a period of ischemia. In the immediate post-transplant period, ischemia-reperfusion injury increases the risk of primary failure or dysfunction of the transplanted graft and complicates the post-transplant management of the recipient. To date there is no therapy for the prevention or treatment of ischemia-reperfusion injury. Recently, new mediators have been identified that have the potential to be effective therapeutic targets on which to design new strategies that successfully protect against ischemia-reperfusion. This literature review discusses the relevance of ischemia-reperfusion injury in organ transplantation and its pathogenic mechanisms, as well as some trends in therapeutic strategies that have the potential to achieve a clinical application.


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