2013, Number 2
<< Back Next >>
Rev Mex Med Repro 2013; 5.6 (2)
Effect of Body Mass Index on Alive Newborns Rate in Pregnancies Achieved by in Vitro Fertilization
Bonifacio LE,Reyes ME,Basulto ME, de la Jara DJF,Barros DJC,Santibáñez MÁ,Sánchez SV
Language: Spanish
References: 25
Page: 90-96
PDF size: 345.21 Kb.
ABSTRACT
Background: In Mexico there has been an increased percentage
of infertile couples and, besides, an increased number of
infertile women with overweight and obesity reaching pregnancies
by
in vitro fertilization. Overweight and obesity are related to a
significantly higher risk of complications, such as preeclampsia,
gestational diabetes mellitus, preterm birth, cesarean section,
shoulder dystocia and postpartum complications.
Objective: To know the effect of body mass index ≤ 25 kg/m
2 on
the incidence of alive newborns and the adverse perinatal results
of women with pregnancies obtained by
in vitro fertilization.
Patients and method: Historic cohort study including 156 women
with pregnancy obtained by
in vitro fertilization, and corroborated
16 to 20 hours later by identifying two pronuclei, with prenatal
control and pregnancy resolution at our Institution from January
2006 to December 2010. Two groups were conformed: group
1, with women with body mass index ‹ 25, and group 2, with
women with body mass index ≤ 25 at the beginning of the
in
vitro fertilization cycle.
Results: One hundred fifty-six women who obtained pregnancy
by
in vitro fertilization were included; 77 women had overweight
(body mass index 25-29.9 kg/m
2) and only 12 women had obesity.
A mild tendency of higher proportion of abortion was observed
in the group 2 (20.2%
vs 16.4%) as well as a higher incidence of
alive newborns in the group 1 (64.2%
vs 58.4%), without statistically
significant difference.
Conclusions: Body mass index ≤ 25 kg/m
2 does not affect incidence
of alive newborns, nor incidence of abortion, but it is related
to a higher risk of preeclampsia and a higher trend to gestational
diabetes mellitus in Mexican women achieving pregnancy by
in
vitro fertilization.
REFERENCES
Arellano S, Bastarrachea R, Bourges H. La obesidad en México, posición de la Sociedad Mexicana de Nutrición y Endocrinología. Rev Endocrinol Nutr 2010;12:80-87.
Olaiz-Fernández G, Rivera-Dommarco J, Shamah-Levy T, Rojas R, et al. Encuesta Nacional de Salud y Nutrición 2006. Cuernavaca: Instituto Nacional de Salud Pública, 2006.
Maheshwari A. Overweight and obesity in infertility: cost and consequences. Human Reprod Update 2010;16:229-230.
Norman RJ, Chura LR, Robker RL. Effects of obesity on assisted reproductive technology outcomes. Fertil Steril 2008;89:1611-1612.
Orvieto R, Meltcer S, Nahum R, Rabinson J, et al. The influence of body mass index on in vitro fertilization outcome. Int J Gynecol Obstet 2009;104:53-55.
Martinuzzi K, Ryan S, Luna M, Copperman A. Elevated body mass index (BMI) does not adversely affect in vitro fertilization outcome in young women. J Assist Reprod Genet 2008;25:169-175.
Bellver J, Melo M, Bosch E, Serra V, et al. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril 2007;88:446-451.
Kupka MS, Gnoth C, Buehler K, Dahncke W, et al. Impact of female and male obesity on IVF/ICSI: results of 700,000 ARTcycles in Germany. Gynecol Endocrinol 2011;27:144-149.
Yogev Y, Catalano P. Pregnancy and obesity. Obstet Gynecol Clin N Am 2009;36:285-300.
American College Obstetrics and Gynecology. Committee opinion. Obesity in pregnancy. Obstet Gynecol 2005;106:671-675.
Barros JC, Alvarado L, Gorbea C, Villalobos S, et al. Resultados perinatales de embarazos por fertilización in vitro con transferencia de embriones (FIVTE): un estudio de casos y controles. Ginecol Obstet Mex 2006;74:626-639.
Instituto Nacional de Perinatología. Normas y procedimientos de ginecología y obstetricia. Ed. Marketing y Publicidad de México, 2003.
Shah D, Missmer S, Berry K, Racowsky C, et al. Effect of Obesity on Oocyte and Embryo Quality in Women Undergoing In Vitro Fertilization. Obstet Gynecol 2011;118:63-70.
Vilarino FL, Blanco B, Christofolini DM, Barbosa CP. Impact of body mass index on in vitro fertilization outcomes. Rev Bras Ginecol Obstet 2010;32:536-540.
Dechaud H, Anahory T, Reyftmann L, Loup V, et al. Obesity does not adversely affect results in patients who are undergoing in vitro fertilization and embryo transfer. Eur J Obstet Gynecol Reprod Biol 2006;127:88-93.
Zhang D, Zhu Y, Gao H. Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilization: a cohort study of 2628 Chinese women. Gynecol Endocrinol 2010;26:325-332.
Metwally M, Ong KJ, Ledger WL, Phil D, et al. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril 2008;90:714-726.
Li Y, Yang D, Zhang Q. Impact of overweight and underweight on IVF treatment in Chinese women. Gynecol Endocrinol 2010;26:416-422.
Michalakis KG, Segars JH. The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction. Fertil Steril 2010;94:1949-1957.
Jungheim ES, Moley KH. Current knowledge of obesity’s effects in the pre- and periconceptional periods and avenues for future research. Am J Obstet Gynecol 2010;203:525-530.
Weiss JL, Malone FD, Emig D, Ball RH, et al. Obesity, obstetric complications and cesarean delivery rate -a population-based screening study. Am J Obstet Gynecol 2004;190:1091-1097.
Catalano P. Obesity, insulin resistance, and pregnancy outcome. Reproduction 2010;140:365-371.
Reyes E, Martínez N, Parra A, Castillo-Mora A, Ortega- González C. Early intensive obstetric and medical nutrition care is associated with decreased prepregnancy obesity impact on perinatal outcomes. Gynecol Obstet Invest 2011 DOI:10.1159/000329899.
Herring SJ, Oken E, Rifas-Shiman SL, Rich-Edwards JW, et al. Weight gain in pregnancy and risk of maternal hyperglycemia. Am J Obstet Gynecol 2009;201:61.
Saldana TM, Siega-Riz AM, Adair LS, Suchindran C. The relationship between pregnancy weight gain and glucose tolerance status among black and white women in central North Carolina. Am J Obstet Gynecol 2006;195:1629-1635.