Beltrán VCE, Díaz CF, Gómez EH

Language: Spanish
References: 31
Page: 619-631
PDF size: 777.88 Kb.

ABSTRACT

Introduction: Colombia is the second country with the highest biodiversity in the world, about 10 % of the world's plant resources are represented by 50,000 species of plants, and the north Colombian´s coast has about 3,400 of these species. This region is characterized by maintaining a rich tradition of use of this natural resource to treat several primary health problems.
Objective: to conduct a phytochemical study of 45 ethanol extracts of 39 plants, which are used in traditional medicine in the Colombian Atlantic coast, with the aim of contributing to science-based knowledge of secondary metabolites present in these plants.
Methods: different organs from each species were collected, fresh drug was subjected to successive extractions with 98 % ethanol and were identified in the extracts different groups of secondary metabolites present in each plants.
Results: in the different ethanol extracts was detected high diversity of secondary metabolites; flavonoids, anthracene derivatives, triterpenes, cardiotonic compounds and alkaloids were predominantly present in each extracts. This studies were reported for first time the phytochemical study for species such as Sarcostemma clausum (Jacq) Schult., Diospyros inconstans Jacq., Sterculia apetala (Jacq.) Karst., Ceratopteris pteridoides Hooker., Cecropia peltata L., Cordia dentata Poir. and Gustavia superba (Kunth) O. Berg.
Conclusions: there was evidence the presence of flavonoids as phytoconstituents most abundant in the species selected. The results provide support for further chemical and pharmacological studies of these species.

REFERENCES

1. Kiruba S, Mahesh M, Paul Z M, Jeeva S. Preliminary phytochemical screening of the pericarp of Crataeva magna (Lour.) DC.-a medicinal tree. Asia Pac J Trop Biomed. 2011;1(1):S129-S130.

2. Sasmal S, Majumdar S, Gupta M, Mukherjee A, Mukherjee P. Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb. Asia Pac J Trop Biomed. 2012;2(10):782-6.

3. Diaz F, Kardono l, Douglas AK, Fairchild CR, Farnasworth NR, Cordell GA, et al. Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo L. J Nat Prod. 2003;66(6):865-7.

4. Diaz F, Urbina D, Mendoza K, Puello M, Gaitan R. Cytotoxicity of native sponges and plants from the Colombian Caribbean coast against Crown Gall tumors induced by Agrobacterium tumefaciens. Letters in Drug Design & Discovery. 2006;3(9):640-4.

5. Díaz F, Morelos S, Carrascal M, Pájaro Y, Gómez H. Actividad larvicida de extractos etanólicos de Tabernaemontana cymosa y Trichilia hirta sobre larvas de estadio III y IV de Aedes aegypti (Diptera: Culicidae). Rev Cubana Plant Med. 2012;17(3):256-67.

6. Ordoñes P, Vega M, Malagon O. Phytochemical study of native plant species used in traditional medicine in Loja Province. J Ecology Appliation. 2006;10(2):65-71.

7. Bahadur M, Münzbergová Z, Timsina B. Ethnobotanical study of medicinal plants from the Humla District of Western Nepal. J Ethnopharmacol. 2010;130(3):485-504.

8. Gómez H, Díaz F, Franco L, Mercado J, Guzmán J, Domingo J, et al. Folk medicine in the Northern Coast of Colombia: An overview. J Ethnobiology Ethnomedicine. 2011;7(1):27. doi:10.1186/1746-4269-7-27

9. Heinrich M. Plantas medicinales Iberoamericanas. J Ethnopharmacol. 2009;124(3):656-7.

10. Romero M, Cabrera E, Ortiz N. Informe nacional sobre el avance en el conocimiento y la información de la biodiversidad 1998-2004. Bogotá, Colombia: Instituto de Investigación en Recursos Biológicos Alexander von Humboldt; 2006.

11. Andrade MG. Estado del conocimiento de la biodiversidad en Colombia y sus amenazas. Consideraciones para fortalecer la interacción ciencia-política. Rev Acad Colomb Cienc Exactas Fís Nat. 2011;35(137):492-508.

12. Meisel A, Pérez G. Documentos de Trabajo Sobre Economía Regional: Geografía Física y Poblamiento en la Costa Caribe Colombiana. Cartagena- Colombia: Banco de la República; 2006. Disponible en: http://www.banrep.gov.co/documentos/publicaciones /regional/documentos/DTSER-73.pdf

13. Domínguez XA. Métodos de Investigación Fitoquímica. México: Limusa S.A.; 1973.

14. Wagner H, Bladt S. Plant Drug Analysis: A Thin Layer Chromatography Atlas. 2nd ed. Berlin-Heidelberg-New York: Springer-Verlag; 1996.

15. Lopez A, Hudson JB, Towers GHN: Antiviral and antimicrobial activities of Colombian medicinal plants. J Ethnopharmacol. 2001;77(2-3):189-96.

16. Mekhora C, Muangnoi C, Chingsuwanrote P, Dawilai S, Svasti S, Chasri K, et al. Eryngium foetidum suppresses inflammatory mediators produced by macrophages. Asian Pac J Cancer. 2012;13(2):653-64.

17. Hassan M, Saha A, Khan S, Islam A, Zaman M, Ahmed SU. Studies on the antidiarrhoeal, antimicrobial and cytotoxic activities of ethanol-extracted leaves of yellow oleander (Thevetia peruviana). Open Veterinary J. 2011;1:28-31.

18. Kim H. Do not put too much value on conventional medicines. J Ethnopharmacol. 2005;100(1-2):37-9.

19. Noguera B, Diaz E, Garcia M, Feliciano A, López J, Israel A. Anti-inflammatory activity of leaf extract and fractions of Bursera simaruba (L.) Sarg (Burseraceae). J Ethnopharmacol. 2004;92(1):129-33.

20. Germosén-Robineau L, Delens M, García-González M, Herrera J, Morón F, Sáenz-Campos D, et al. Farmacopea Vegetal Caribeña. 2da ed. León-Nicaragua: Editorial Universitaria, UNAN León; 2005.

21. Javaid A, Amin M. Antifungal activity of methanol and n-hexane extracts of three Chenopodium species against Macrophomina phaseolina. Natural product research. 2009;23(12):1120-7.

22. Barbosa WLR, Peres A, Gallori S, Vincieri FF. Artigo determination of myricetin derivatives in Chrysobalanus icaco L. Rev Bras Farmacogn. 2006;16(3):333-7.

23. Taborda N, Patiño C, Forero J, López A. Actividad antiviral in vitro de extractos de Hura crepitans y Codiaeum variegatum en la replicación de herpes virus bovino tipo-1 y virus de estomatitis vesicular. Rev Colom Cienc Pecua. 2007;20(3):241-9.

24. Abreu P, Matthew S, González T, Costa D, Segundo M, Fernandes E. Anti-inflammatory and antioxidant activity of a medicinal tincture from Pedilanthus tithymaloides. Life sciences. 2006;78(14):1578-85.

25. Nagaraju B, Srinivas N, Sandeep K. A comparative pharmacological and phytochemical analysis of in vivo & in vitro propagated Crotalaria species. Asian Pacific J Tropical Med. 2012;5(1):37-41.

26. Mohana DC, Raveesha KA. Anti-bacterial activity of Caesalpinia coriaria (Jacq.) Willd. Against plant pathogenic Xanthomonas pathovars: an eco- friendly approach. J Agricultural Technology. 2006;2(2):317-27.

27. Pradeep K, Raj C, Gobianand K, Karthikeyan S. Effect of Cassia fistula Linn. leaf extract on diethylnitrosamine induced hepatic injury in rats. Chemico-Biological Interactions. 2007;167(1):12-8.

28. Alanís AD, Calzada F, Cervantes JA, Torres J, Ceballos GM. Antibacterial properties of some plants used in Mexican traditional medicine for the treatment of gastrointestinal disorders. J Ethnopharmacol. 2005;100(1-2):153-7.

29. Diaz F, Morelos S, Carrascal M, Pajaro Y, Gomez H. Actividad larvicida de extractos etanólicos de Tabernaemontana cymosa y Trichilia hirta sobre larvas de estadio III y IV de Aedes aegypti (Diptera: Culicidae), Rev Cubana Plant Med. 2012;17(3):256-67.

30. Svetaz L, Zuljan F, Derita M, Petenatti E, Tamayo G, Cáceres A, et al. Value of the ethnomedical information for the discovery of plants with antifungal properties. A survey among seven Latin American countries. J Ethnopharmacol. 2010;127(1):137-58.

31. Kubmarawa D, Ajoku GA, Enwerem NM, Okorie DA. Preliminary phytochemical and antimicrobial screening of 50 medicinal plants from Nigeria. African J Biotechnol. 2007;6(14):1690-6.