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ISSN 1561-3046 (Electronic)

2013, Number 3

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Rev Cub Med Mil 2013; 42 (3)

Prevalence of microvascular angina in patients from the Center for Medical Surgical Research

Aldama PLI, Aroche AR, Obregón SÁG, Conde CH, Padrón PR

Language: Spanish
References: 20
Page: 387-395
PDF size: 218.04 Kb.


ABSTRACT

Introduction: a considerable number of patients undergoing coronary arteriography do not present any atherosclerotic lesions in their coronary tree. The subgroup with chest pain and a positive ergometric test was included in the diagnosis of microvascular angina.
Objective: determine the prevalence of microvascular angina in patients undergoing coronary arteriography.
Methods: descriptive cross-sectional study of patients examined at the Hemodynamic Laboratory of the Center for Medical Surgical Research from 2010 to 2011, initially diagnosed with effort angina and with a positive ergometric test. The study universe was 1 452 patients undergoing coronary arteriography in the period. The sample consisted of the 452 patients who did not show any coronary atherosclerotic lesions.
Results: 31.1 % of the patients undergoing coronary arteriography had microvascular angina, with a predominance of the female sex. Arterial hypertension was the main risk factor throughout the two years' evaluation.
Conclusions: microvascular angina, a common condition in Cuba, is related to the presence of cardiovascular risk factors.


REFERENCES

  1. Kaski JC. Cardiac syndrome X and microvascular angina. In: Kaski JC, editor. Chest pain with normal coronary angiograms. Pathogenesis, diagnosis and management. Massachusetts: Norwell Kluwer Academic Publishers; 1999. p. 1-12.

  2. Kemp HG. Left ventricular function in patients with anginal syndrome and normal coronary arteriograms. Am J Cardiol. 1973;32:375-6.

  3. Quyyumi AA, Mulcahy D, Andrews NP, Panza JA, Cannon RO. Coronary vascular nitric oxide activity in hypertension and hypercholesterolemia. Comparison of acetylcholine and substance P. Circulation. 1997;95:104-10.

  4. Johnson BD, Shaw LA, Buchthal SD, Bairey Merz N, Kim HW, Scott KN, et al. Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease. Circulation. 2004;109:2993-9.

  5. Reis S, Holubkov R, Conrad Smith A, Kelsey S, Sharaf B, Reichek N, et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J. 2001;141:735-41.

  6. Kemp HG, Kronmal RA, Vliestra RE, Frye RL. Seven years survival of patients with normal or near normal coronary arteriograms: a CASS registry study. J Am Coll Cardiol. 1986;7:479-83.

  7. Kaski JC, Rosano GM, Collins P, Nihoyannopoulos P, Maseri A, Poole-Wilson PA. Cardiac syndrome X. Clinical characteristics and left ventricular function. Long-term follow-up study. J Am Coll Cardiol. 1995;25:807-15.

  8. Shaw LJ, Bugiardini R, Bairey Merz N. Women and ischemic heart disease. Evolving knowledge. J Am Coll Cardiol. 2009;54:1561-75.

  9. Rosano GM, Collins P, Kaski JC, Lindsay DC, Sarrel PM,Poole-Wilson PA. Syndrome X in women is associated with estrogen deficiency. Eur Heart J. 1995;16:610-4.

  10. Lanza GA, Crea F. Primary Coronary Microvascular Dysfunction. Circulation. 2010;121:2317-25.

  11. Oki T, Tabata T, Yamada H, Wakatsuki T, Mishiro Y, Abe M, et al. Left ventricular diastolic properties of hypertensive patients measured by pulsed tissue Doppler imaging. J Am Soc Echocardiogr. 1998;11:1106-12.

  12. Schafer S, Kelm M, Mingers S, Strauer BE. Left ventricular remodeling impairs coronary flow reserve in hypertensive patients. J Hypertens. 2002;20:1431-7.

  13. Morkin E, Ashford TP. Myocardial DNA syntesis in experimental cardiac hypertrophy. Am J Physiol. 1968;215:1409-13.

  14. Lüscher TF, Tanner FC, Dohi Y. Age, hypertension and hypercholesterolaemia alter endothelium-dependent vascular regulation. Pharmacol Toxicol 1992;70:S32-S39.

  15. Strauer BE. The significance of coronary reserve in clinical heart disease. J Am Coll Cardiol. 1990;15:755-83.

  16. Tomanek RJ. Response of the coronary vasculature to myocardial hypertrophy. J Am Coll Cardiol. 1990;15:528-33.

  17. Bugiardini R, Bairey Merz CN. Angina with "normal" coronary arteries: a changing philosophy. JAMA. 2005;293:477-84.

  18. Johnson BD, Shaw LJ, Buchthal SD, Bairey Merz CN, Kim HW, Scott KN, et al. Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation. 2004;109:2993-9.

  19. Bugiardini R, Manfrini O, Pizzi C, Fontana F, Morgagni G. Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation. 2004;109:2518-23.

  20. Vermeltfoort I, Bondarenko O, Raijmakers P, Odekerken D, Kuijper A, Zwijnenburg A, et al. Is subendocardial ischaemia present in patients with chest pain and normal coronary angiograms? A cardiovascular MR study. Eur Heart J. 2007;28:1554-8.




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