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2012, Number 4

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Med Sur 2012; 19 (4)

Entendiendo el inmunofenotipo de las neoplasias de células B maduras

Sarmiento-Chavero M, Gabiño-López NB

Language: Spanish
References: 75
Page: 212-221
PDF size: 185.54 Kb.


ABSTRACT

The mature B cell neoplasms are the most frequent lymphoid tumors. In the last 10 years there have been some drastic changes in their classification. Previously, we only used morphologic criteria, but in the last World Health Organization (WHO) classification of 2008, the use of molecular biology and cytogenetic criteria was improved. We currently have over 25 types of mature B cell neoplasms, which share a common origin (the mature B cells) but have differences in gene expression and phenotype, and therefore show a wide variation in natural history and response to treatment. For the proper study and treatment of hematologic and lymphoid neoplasms is now essential to have knowledge of molecular biology and cytogenetic, as these criteria have evolved beyond the classification and have become the basis of therapeutics. Some of the major subtypes of neoplasms mature B cell lymphoma are: diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma and marginal zone lymphoma. Sometimes the differential diagnosis by light microscopy of these tumors is difficult (if not impossible). Immunohistochemistry analysis has become an essential tool in the pathology laboratory. The aim of this review is to help the medical team to understand the classification of mature B neoplasms, because it is a complicated but critical subject for the proper management of these neoplasms.


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