Rivera-Ordóñez A

Language: Spanish
References: 19
Page: 36-40
PDF size: 117.11 Kb.

ABSTRACT

Non-steroidal anti-inflammatory drugs (NSAIDs) form a wide group of drugs, with shared therapeutic actions and side effects. NSAIDs have various central and peripheral effects, most of which are mediated through the inhibition of prostaglandin (PG) synthesis. Their analgesic effect is based on the blockade of the peripheral and central production of prostaglandins; at the central level, the sensitization of spinal and supraspinal neurons is prevented, allowing for the modulation (inhibition) of pain. Previous research on the central nervous system (CNS) and the activity of inflammatory cells, enzyme liberation, and free radicals derived from oxygen and other mechanisms, reveal that the effects of NSAIDs may be independent from prostaglandin synthesis. Considering all the aforementioned, plus the fact that cyclooxygenase inhibitors can be useful to considerably reduce pain and inflammation, these drugs are essential for the control of acute and chronic pain, and for preventing or reducing nociceptive impulses, by giving them both before and after soft tissue injury.

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