Briones-Corona G, Moreno-Alatorre MA, Lozano-Noriega R

Language: Spanish
References: 0
Page: 20-25
PDF size: 107.21 Kb.

ABSTRACT

Objective: To demonstrate the effectiveness of dexmedetomidine infusion to reduce anesthetic requirements in patients undergoing heart surgery with cardiopulmonary bypass. Materials and methods: Forty patients, male and female, ages 10 to 80 years old, scheduled for elective surgery, were randomized into two groups, 20 patients each. Group I was the control group; patients in Group II were given a 1 μg/kg bolus of dexmedetomidine, and a 0.5 μg/kg/h maintenance dose before and after cardiopulmonary bypass. Fentanyl, isofluorane, and inotropic requirements; halogenated concentration; as well as mean blood pressure and heart rate at the beginning and the end of surgery were measured. Statistical analysis was performed using a Student’s t test (p ‹ 0.05). Results: Narcotics requirements in group I were 9.3 ± 1.2 μg/kg/hour and in group II, 4.8 ± 1.2 μg/kg/hour (p ‹ 0.05); halogenated requirements in group I were 9.7 ± 0.3 percent volume, and in group II, 0.52 ± 0.08 percent volume (p ‹ 0.05). No significant differences in cardiovascular parameters (mean blood pressure, heart rate and inotropic requirements) were seen among the two groups. Conclusions: Dexmedetomidine used during cardiac surgery with cardiopulmonary bypass appeared to be effective in decreasing narcotic and halogenated requirements, with no need for inotropic support.