Exploratory Study of Serum Immunoglobulin in Pediatric Patients with Giardia lamblia Infection

Judith Sánchez-Aviles; Carlos Arturo Velázquez-Contreras; Humberto Astiazaran-García; Lucila Rascón; Norberto Sotelo-Cruz

2013, Number 2

<< Back Next >>

Bol Clin Hosp Infant Edo Son 2013; 30 (2)

**Exploratory Study of Serum Immunoglobulin in Pediatric Patients with Giardia lamblia Infection**

Sánchez-Aviles J, Velázquez-Contreras CA, Astiazarán-García H, Rascón L, Sotelo-Cruz N

Full text

How to cite this article

Language: Spanish
References: 19
Page: 63-67
PDF size: 41.84 Kb.

ABSTRACT

Objective: To found the sings and symptoms in children and relationship with the levels of blood immunoglobulin.
Methods: A prospective and observational study in infected patients with GL in external patients of the Hospital Infantil del Estado de Sonora in 2011.The variables were age, genus, signs and symptoms, allergy manifestations. We made the following laboratory test: hematic biometry, parasitic in stool, levels in blood of immunoglobulin IgA, IgM, IgG, IgE. The Project was approved by ethical committee.
Results: 24 children were included the most affected ages were, the lees of 3 years old; 25% of the patient haven deficient nutrition. Signs and symptoms gastrointestinal in 50% .immunoglobulin levels of IgA, had diminished in 25%. Furthermore 87.5 % of the patients haven high levels of IgE, only two presents urticarial.
Conclusion: The IgE levels were major in children with less of 3 years old; the clinical features en the GL infected patients, do not have relationship with immunoglobulin levels.Isis necessary amplest the study.

REFERENCES

1.- AnkrakevJ,JerostomJ,Ringqvist E, Troe K. Behind the smile:cell biology and disease mechanisms of guardia species Nat rev Microlbiology 2010;doi:10.1038/nrmicro 2317. 2.- Vázquez TO, Campos R. Giardiasis. La parasitosis más frecuente a nivel mundial. Revista Centro de investigación La Salle. 2009; 8 (31): 75-90.
3.- Mexicano HH, Sotelo CN. Revisión de Parasitosis en el Hospital Infantil del Estado de Sonora en un periodo de 10 meses. Tesis 1997.UNAM.Febrero de 1998.
4.- Uribaren BT.Giardiasis.Departamento de Microbiología y parasitología Facultad Medicina UNAM. 2012.
5.- López AE. Prevalencia de enteroparasitosis en menores de 5 años, Hospital Universitario UNIVALLE 2002- 2005. RevInv e Infor Salud 2006; 2(4): 22-6.
6.- Quhui L, Morales GG, Mendez OR, Leyva JG, Esparza J, Valencia ME. Could giardiasis be a risk factor for low zinc status in schoolchildren from northwestern Mexico? A cross sectional study with longitudinal follow-up.BMC Public Health 2010; 85: 1-7
Dohi FB, Martínez VR Godoy OL,Cmpbell AO. Evaluación de dos esquemas cortos de nitroimidazolesSecnidazol y tinidazolen el tratamiento de giardiasis en el niño. BolClinHospInfant. Edo Son 1990; 7: 38-45.
8.- Kampitak T. selective immunoglobulin deficiency in a patient with a refractory giardiasis.J Invest Allergol Clin Immunol.2010;20(4) 352-63.
9.- López SM, AmorósHA, Caravaca EF. Angioedema crónico asociado a Giardialamblia. A Pediatr. 2008;69(6): 588- 89.
10.- Long ZK, Rosado JL, Santos JI, Haas M, Mamun AA, Dupont HL, Nanthakamur Estrada GT. Association betwen mucosal innate and adaptative immune responses and resolution of diarrheal pathogen infections. Infection and Immunity 2010; 78(3):1221-8.
11.- Karna JM, Piekarska VD, Kemona H. IFN-gamma, IL-5,IL-6 and IgE in infectepatients with Giardia Intestinalis. Folia Histochemica et Cytobilogica 2002;47(1): 93-7.
12- Gottstein B, Harriman GR, Conrad JT, Nash TE. Antigenic variation in Giardia lamblia: cellular and humoral immune response in a mouse model. Parasite Immunol. 1990; 12(6): 659-73.
13.- Chávez MP, Fernández J. Tendencia de la prevalencia y factores asociados a la infección por Giardiaduodenalis en escolares y prescolares de una zona rural de Cundinamarca. Biomédica. 2007; 27(3): 345- 51.
14.- Sotelo CN, Acosta E S. Martínez VR. Concentración plasmática de hierro y ferritina en niños par asitados por Giardialamblia.RevMexPediatr 1995; 62 (6) : 214-8.
15.- Astiazaran GH, Lopez TV, Valencia ME, Vazquez OF, Sotelo CN, QuihuiCotaL.GiardiaLamblia Infection and its implications for vitamin A stores in School children.Annals of Nutrition and Metabolism.2010; 57: 228-33.
16.- Iglesias HT, Almannoni A, Rodríguez BM. Conocimiento, percepciones y prácticas de los dermatólogos en relación a la infección por Giardia lamblia. RevCubMedTrop 2010;62 (1): 36 - 41.
17.- Rodríguez VN, Martínez PT. Giardiasis intestinal: estudio de 60 pacientes. RevCubPediatr 2006; 78(2).
18.- Quintana D J. Manifestaciones Clínicas Bucales detectables en pacientes con giardiasis. Rev Cubana Estomatol 1997; 34(2): 80-3.
19.- Alfaro H I. Giardiasis y desnutrición.RevSoc.Bol. Ped. 2005; 44: 166-73.
20.- Salinas CM. Anticuerpos. Estructura, función y uso terapéutico en: Inmunología médica. Mc Graw Hill Interamericana Eds. México. 2007: 44-56.