2013, Number 2
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Bol Clin Hosp Infant Edo Son 2013; 30 (2)
Analgesic Effect of 25% Glucose Solution vs. EMLA Cream. PIPP Scale Evaluation
Guzmán-Arteaga AN, Fajardo-Ochoa F, Ramírez-Rodríguez CA, Alvarez-Hernández G
Language: Spanish
References: 17
Page: 56-62
PDF size: 107.12 Kb.
ABSTRACT
Introduction: The venipuncture is the method of choice for blood sampling in the neonate, causing moderate pain
intensity. The use of glucose and the aplications of EMLA cream are the most studied interventions of pain in neonates,
with varying results.
Objectives: Evaluate the analgesic effect of 25% dextrose solution and EMLA cream in premature neonate measured by the PIPP
pain scale during the venipuncture for blood sampling and during his internment in the Neonatology Service of the Children’s
Hospital of Sonora (HIES).
Methods: A controlled, double-blind, randomized,clinical study was performed, in the service of growth and development at our
Children‘s Hospital, in 24 prematures of 28 to 36.6 weeks of gestation. They were divided into 2 groups: group 1 was given 0.5 ml of
25 dextrose solution by suction and in group 2 EMLA cream was applied prior to blood sampling by venipuncture. They were
assessed with the Scale of Pain Profile of the Premature (PIPP).
Results: There was no significative difference in the pain scale score between infants who received 25% of dextrose solution and
those who received EMLA cream at p 0.1046.
Conclusion: Both use of 25% dextrose solution as the aplication of EMLA cream were equally effective in reducing pain during
venipuncture. We recommend using 25% of dextrose solution that is non-invasive, with easy acquisition and for their safety.
REFERENCES
1.- Comunidad de Madrid, Dirección General de Farmacia y Productos Sanitarios. Efectividad de Medicamentos en Neonatologia. Sedoanalgesia en el Recién Nacido. Marzo 2007(4): 1-14.
2.- Stevens B, Johnston C, Petryshen P, Taddio A. Premature infant pain profile: development and initial validation. Clin J Pain. 1996; 12: 1322.
3.- Pérez R, Villalobos E, Aguayo K, Guerrero M. Valoración y estrategias no farmacológicas en el tratamiento del dolor neonatal. Rev Cubana Pediatr 2006; 78 (3).
4.- Shah V and Ohlsson A. Venopuncture versus heel lance for blood sampling in term neonates. The Cochrane Database of Systematic Reviews 2006, Issue 1. Chichester: John Willey and sons.
5.- American Academy of Pediatrics. Committee on Fetus and Newborn and Section on Surgery, Canadian Paediatric Society and Fetus and Newborn Committee. Prevention and Management of Pain: An Update. Pediatrics. 2006; 118: 2231- 41.
6.- Stevens B, Yamada J and Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. The Cochrane Database of Systematic Reviews 2006, Issue 1 Chichester: John Willey and sons.
7.- Betancourt-Fuentes CE, Espinosa-García JO, et al. Estrategias no farmacológicas en el alivio del dolor del recién nacido en procedimientos de enfermería. Rev Enferm Inst Mex Seguro Soc. 2008; 16(2): 83-8.
8.- Carbajal R, Lenclen R, Gajdos V, Jugie M and Paupe A. Crossover trial of analgesic efficacy of glucose and pacifier in very preterm neonates during subcutaneous injectios. Pediatrics. 2002; 110: 389-93.
9.- Ficha técnica EMLA® crema 30g, (25mg/g) Astra-Zeneca Farmacéutica. Texto revisado en marzo 2003.
10.- Stevens B, Johnston C, Petryshen P, Taddio A. Premature Infant Pain Profile: development and initial validation. Clin J Pain. 1996;12(1): 13–22.
11.- Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2010;(1): CD001069.
12.- Biran V, Gourrier E, Cimerman P, Walter-Nicolet E, Mitanchez D, Carbajal R. Analgesic Effects of EMLA Cream and Oral Sucrose During Venipuncture in Preterm Infants. Pediatrics. 2011; 128; e63.
13.- Lefrak L, Burch K, Caravantes R, et al. Sucrose analgesia: identifying potentially better pract ices. Pediatrics. 2006;118(suppl 2):S197–S202.
14.- Acharya AB, Bustani PC, Phillips JD, Taub NA, Beattie RM. Randomised controlled trial of eutectic mixture of local anaesthetics cream for venepuncture in healthy preterm infants. Arch Dis Child Fetal Neonatal Ed. 1998;78(2): F138- F142.
15.- Gradin M, Eriksson M, Holmqvist G, Holstein A, Schollin J. Pain reduction at venipuncture in newborns: oral glucose compared with local anesthetic cream. Pediatrics. 2002; 110(6): 1053–7.
16.- Lindh V, Wiklund U, Håkansson S. Assessment of the effect of EMLA during venipuncture in the newborn by analysis of heart rate variability. Pain. 2000; 86(3): 247-54.
17.- Gourrier E, Karoubi P, el Hanache A, et al. Use of EMLA cream in premature and fullterm newborn infants. Study of efficacy and tolerance [in French]. Arch Pediatr. 1995; 2(11): 1041-6.