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Academia Mexicana de Neurología, A.C.

2013, Number 5

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Rev Mex Neuroci 2013; 14 (5)

Transcranial Doppler cerebral vasoreactivity in dementia of the Alzheimer’s type and vascular dementia

Malamud-Kessler C, Huertas-Navarro M, Campos-Sánchez M

Language: Spanish
References: 53
Page: 254-261
PDF size: 184.86 Kb.


ABSTRACT

Introduction: Alzheimer’s disease and vascular dementia are the two most frequent forms of severe cognitive impairment. Their distinction is of undisputed prognostic and therapeutic importance.
Objective: To determine whether differences exist between cerebral vasoreactivity parameters measured by transcranial Doppler in patients with Alzheimer’s disease and probable vascular dementia clinically defined.
Methods: We recruited 70 patients divided into two groups: Alzheimer’s and probable vascular dementia clinically defined. We recorded clinical data and rated the severity of dementia. Subsequently we performed a transcranial Doppler consigning hemodynamic parameters before and after the apnea test.
Results: The cerebral vasoreactivity measured by transcranial Doppler showed a sensitivity of 52% (95% CI: 33.5-69.7) and specificity of 80% (95% CI: 66.18-89.1) for the differential diagnosis of probable vascular dementia. There was not a relationship between the severity, time of illness or the presence of vascular risk factors with cerebral vasoreactivity.
Conclusions: This method can be a diagnostic aid test for detection of probable vascular dementia. We recommend further studies to establish relationships with respect to cerebral vasoreactivity, vascular risk factors, disease duration and severity in dementia.


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