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Academia Mexicana de Neurología, A.C.

2013, Number 6

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Rev Mex Neuroci 2013; 14 (6)

Relevance of brain volume loss in multiple sclerosis and impact of disease modifying therapies in reducing brain atrophy

Mendoza-Bernal JA, Jiménez-González ME, Chiquete E, González-HIF

Language: Spanish
References: 47
Page: 341-348
PDF size: 207.11 Kb.


ABSTRACT

The loss of brain tissue in patients with multiple sclerosis (MS) is up to 4 times greater than that occurring in normal subjects by the normal aging process. The disease-modifying treatments (DMT) are focused mainly in the control of inflammation. Nonetheless, sphingosine analogues have shown a class effect in reducing the progression of brain tissue loss. This opens a new horizon in the treatment goals of patients with MS, not only in the management of the initial stages of active inflammation, but also in chronic forms, when there is accelerated loss of brain tissue. The aim of this narrative review is to discuss the role of emerging DMTsin preventing brain atrophy in MS patients, and in particular, fingolimod, the sphingosine analog currently available in the market.


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