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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2013, Number 4

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Rev Invest Clin 2013; 65 (4)

Decrease of liver fat content by aerobic exercise of metformin therapy in overweigth or obese women

Sánchez-Muñoz V, Salas-Romero R, Del Villar-Morales A, Martínez-Coria E, Pegueros-Pérez A, Franco-Sánchez JG

Language: Spanish
References: 46
Page: 307-317
PDF size: 173.34 Kb.


ABSTRACT

Introduction. Nonalcoholic fatty liver disease (NAFLD) is characterized by high intrahepatic triglyceride content. It has been associated with an increased prevalence of cardiovascular disease, independently of underlying cardiometabolic risk factors. Metformin has been used as pharmacologic treatment; however the adherence is low due to adverse effects. Aerobic exercise can be an alternative therapy, but its effectiveness has not been established in the treatment of NAFLD compared with metformin. Aim. To establish this effectiveness and its influence in reducing cardiovascular risk in overweight or obese women. Material and methods. Women 25-60 years with a body mass index (BMI) › 24.9 kg/m2, sedentary, with liver fat content ‹ 50 UH, were randomly divided into two parallel groups: exercise (EG) or metformin (MG). The EG group performed an aerobic exercise program 60 min/5 days/week at 60-85% of heart rate reserve; the MG group took 1 g/day every morning. The total study duration was 12 weeks. Liver fat content, metabolic and cardiovascular endurance parameters were determined at the beginning and at the end of the program. The study complied with the Helsinki ethic codes in human research. Results. The study included a sample of 16 women, 8 per group. Both treatments modified the liver fat content in 14.6% (CI95% 0.92,28.36) and 10.37% (CI95% -1.74, 22.48) for EG and MG respectively. In the EG group insulin levels and HOMA-IR decreased (P ‹ 0.05), and the cardiovascular fitness was improved. Conclusions. An aerobic exercise program of 12 weeks with a volume training of 300 min/week and a moderate to vigorous intensity (60- 85% VO2peak) modified the liver fat content and improved cardiovascular risk factors during the intervention. The exercise contributed to a more holistic approach by modifying some components of metabolic syndrome, functional capacity, and cardiovascular fitness.


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