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2005, Number 1

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Ann Hepatol 2005; 4 (1)

Effect of cold preservation/reperfusion on glycogen content of liver. Concise review

Quintana AB, Guibert EE, Rodríguez JV

Language: English
References: 36
Page: 25-31
PDF size: 68.21 Kb.


Text Extraction

Livers cold preserved during variable periods of ischemia suffer functional, morphological and hemodynamic alteration, which are exacerbated when they are reperfused. One important injury is glycogen depletion during cold ischemia/ reperfusion. How liver can restore their energy during reperfusion is related with the preservation time, nutritional status of the donor, and the preservation solution used. However, there are some treatments that help livers to preserve their energy storage. These procedures used drugs or metabolites, which are added to the liver to maintain their glycogen storage during preservation, time and allow the organ to restore its energy during reperfusion. There are several publications where the nutritional status of the donor was studied. There is controversy about the quality or the donor organ. Some authors say that fasted animals are better donors because this condition reduced hepatic injuries; others think that fed animals provide the necessary glycogen (energy) to improve liver preservation, reducing morphological and functional damages. Many others are convinced that nutritional status of the donor is not relevant because hepatic injuries will occurred even though the donor was fed or not. The preservation solution has an important role in reducing liver damages during cold ischemia/reperfusion and in restoring liver energy storage. Storage in HLR (histidine, lactobionate and raffinose) solution facilitated the resuscitation of energetic status and preserved adenine nucleotide levels significantly greater than Marshall’s citrate or Bretschneider’s histidine-based solution (HTK). University of Wisconsin (UW) proved to be suitable for energy recovery during reperfusion. In conclusion, the aim of this review is to present studies performed by different authors where they analyzed preservation/reperfusion injuries, how the liver restores its energy storage during reperfusion time, different strategies to avoid glycogen depletion during cold ischemia/reperfusion, the efficacy of preservation solutions and the effect of nutritional status of the donor to prevent functional alteration of the liver during cold preservation.


REFERENCES

  1. Koeppel TA, Gebhard MM, Otto G, Post E. Inhibition of Nitric Oxide Synthesis in Ischaemia/Reperfusion of the Rat Liver is followed by Impairment of Hepatic Microvascular Blood Flow. J Hepatol 1997; 27: 163-169.

  2. Clavien PA. Sinusoidal Endothelial Cell Injury during Hepatic Preservation and Reperfusion. Hepatology 1998; 28: 281-285.

  3. Müller AR, Platz KP, Heckert C, Häusler M, Guckelberger O, Schuppan D, Lobeck, H, et al. The Extracellular Matrix. an early target after small bowel Transplantation. Transplantation 1998; 65: 6 770-776.

  4. Li XK, Matin AFM, Suzuki H, Uno T, Yamaguchi T, Harada Y. Effect of Protease Inhibitor on Ischemia/Reperfusion Injury of the Rat Liver. Transplantation 1993; 56: 1331-1336.

  5. Upadhya AG, Harvey RPC, Howard TK, Lowell JA, Shenoy S, Strasberg SM. Evidence of a Role for Matrix Metalloproteinases in Cold Preservation Injury of the Liver in Humans and in the Rat. Hepatology 1997; 26: 922-928.

  6. Churchill TA, Green CJ, Fuller BJ. Protective Properties of Amino Acids in Liver Preservation: Effects of Glycine and a Combination of Amino Acids on Anaerobic Metabolism and Energetics. J Hepatol 1995; 23: 6 720-726.

  7. Dutkowski P, Southard JH, Junginger T. Liver metabolism during cold ischemic incubation in UW solution in the rat model. Langenbecks Arch Chir 1997; 382(6): 343-348.

  8. Lanir A, Jekins RL, Caldwell C, Lee RGL, Khettry U, Clouse ME. Hepatic transplantation survival: correlation with adenine nucleotide level in donor liver. Hepatology 1988; 8(3): 471-475.

  9. Adam R, Astarcioglu I, Gigou M, Isaac J, Bismuth H. The influence of the glycogen content of the donor liver on subsequent graft function and survival in rat liver transplantation. Transplantation 1992; 54(4): 754-756.

  10. Miki C, Iriyam K, Harrison JD, Gunson BK, D’Silva M, Suzuki H, McMaster P. Glycogen content of the donor liver and its relation to postreperfusion hepatic energy metabolism. Am J Gastroenterol 1997; 92(5): 863-866.

  11. Mitchell SJ, Churchill TA, Winslet MC, Fuller BJ. Effects of different cold preservation solutions on restoration of hepatic energy metabolism during cold reperfusion. Cryobiology 1996; 33: 413-422.

  12. Kamiike W, Burdelski M, Steinhoff G, Ringe B, Lauchart W, Pichlmayr R. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantation. Transplantation 1988; 45(1): 138-143.

  13. Palombo JD, Hirschberg Y, Pomposelli JJ, Blackburn GL, Zeisel SH, Bistrian BR. Decreased loss of liver adenosine triphosphate during hypothermic preservation in rats pretreated with glucose: implications for organ donor management. Gastroenterology 1988; 95(4): 1043-1049.

  14. Quintana AB, Lenzi HL, Almada LL, Scandizzi AL, Furno G, Rodriguez JV, Guibert EE. Effect of S-Nitrosoglutathione (GSNO) added to the University of Wisconsin Solution (UW): II) Functional Response to Cold Preservation/Reperfusion of Rat Liver. Ann Hepatol 2002; 1(4): 183-191.

  15. Cherid A, Cherid N, Chamlian V, Hardwigsen J, Nouthou H, Dodero F, Benkoel L, et al. Evaluation of glycogen loss in human liver transplants. Histochemical zonation of glycogen loss in cold ischemia and reperfusion. Cell Mol Biol (Noisy-le-grand) 2003; 49(4): 509-514.

  16. Dodero F, Benkoel L, Allasia C, Hardwigsen J, Campan P, Botta-Fridlund D, Le Treut YP, et al. Quantitative analysis of glycogen content in hepatocytes of human allograft after ischemia and reperfusion. Cell Mol Biol (Noisy-le-grand) 2003; 49(4): 509-514.

  17. Dodero F, Benkoel L, Hardwigsen J, Campan P, Lambert R, Botta-Fridlund D, Le Treut YP, et al. Effect of ischemia-reperfusion on the heterogeneous lobular distribution pattern of glycogen content and glucose-6-phosphatase activity in human liver allograft. Cell Mol Biol (Noisy-le-grand) 1999; 45(8): 1209-1215.

  18. Tsukamoto K. The recovery of energy metabolism from hypothermic preservation in the rat liver. Nippon Geka Gakkai Zasshi 1988; 89(5): 709-716.

  19. Churchill TA, Fuller BJ. Glycogen phosphorylase activity during the cold storage of liver: A limiting effect on glycolytic flux and energy production. Transplantation 1996; 62(3): 346-352.

  20. Peralta C, Serafin A, Fernández-Zabalegui L, Wu ZY, Roselió-Catafau J. Liver ischemic preconditioning: a new stategy for the prevention of ischemia-reperfusion injury. Transplant Proc 2003; 35: 1800-1802.

  21. Palombo JD, Pomposelli JJ, Fechner KD, Blackburn GL, Bistrian BR. Enhanced restoration of adenine nucleotides in rat liver following extended preservation in UW solution by provision of adenosine during reperfusion. Transplantation 1991; 51: 867-873.

  22. Singh AK, Mani H, Seth P, Gaddipati JP, Kumari R, Banuadha KK, Sharma SC, et al. Picroliv preconditioning protects the rat liver aginst ischemia-reperfusion injury. Eur J Pharmacol 2000; 395: 229-239.

  23. Tsukamoto K, Murakami M, Seo Y, Nonaka M, Kohnosu H, Hironaka T, Oka T, et al. Energetic recovery from hypothermic preservation in the rat liver. J Surg Res 1990; 48(1): 46-50.

  24. Pattou F, Boudjema K, Kerr-Conte J, Barguil Y, Friese N, Wolf P, Jaeck D, et al. Enhancement of the quality of hepatic graft by restoration of hepatic glycogen reserves in the donor. Press Med 1992; 21(4): 2012-2014.

  25. Wakiyama S, Yanaga K, Soejima Y, Nishizaki T, Sugimachi K. Significance of donor nutritional status for rewarming injury of the hepatic graft in rats. Eur Surg Res 1997; 29(5): 339-345.

  26. Boudjema K, Lindell SL, Southard JH, Belzer FO. The effects of fasting on the quality of liver preservation by simple cold storage. Transplantation 1990; 50(6): 943-948.

  27. Sumimoto R, Fukuda Y, Nishihara M, Asahara T, Dobi K. Liver glycogen in fasted rat livers does not improve outcome of liver transplantation. Transpl Int 1996; 9(6): 541-545.

  28. Morgan GR, Sanabria JR, Clavien PA, Phillips MJ, Edwards C, Harvey PR, Strasberg SM. Correlation of donor nutritional status with sinusoidal lining cell viability and liver function in the rat. Transplantation 1991; 51(6): 1176-1183.

  29. Imamura H, Deganais M, Giroux L, Brault A, Huet PM. Cold ischemia-reperfusion injury of the liver. Role of the liver donor nutritional status in rats. Transplantation 1995; 60(1): 14-19.

  30. Sumimoto R, Fukuda Y, Gambiez L, Oshiro H, Dohi K, Southard JH and Belzer FO. Successful 48-h liver preservation by controlling nutritional status of donor and recipient. Transpl Int 1994; 7 Suppl 1: S499-502.

  31. Cywes R, Greig PD, Sanabria JR, Clavien PA, Levy GA, Harvey PR, Strasberg SM. Effect of intraportal glucose infusion on hepatic glycogen content and degradation, and outcome of liver transplantation. Ann Surg 1992; 216(3): 235-246.

  32. Sumimoto R, Southard JH, Belzer FO. Livers from fasted rats acquire resistance to warm and cold ischemia injury. Transplantation 1993; 55(4): 728-732.

  33. Lindell SL, Hansen T, Rankin M, Danielewicz R, Belzer FO, Southard JH. Donor nutritional status – a determinat of liver preservation injury. Transplantation 1996; 61(2): 239 -247.

  34. Pentilla A, Trump BF. Studies on the modification of cellular response to injury. Virchows Arch. B. Cell Pathol 1975; 18: 17-34.

  35. Li XL, Man K, Liu YF, Lee TKW, Tsui SHT, Lau CK, Lo CM, et al. Insulin in University of Wisconsin solution exacerbates the ischemic injury and decreases the graft survival rate in rat liver transplantation. Transplantation 2003; 76(1): 44-49.

  36. Yu WM, Coddington D, Bitter-Suermann H. Rat liver preservation. I. The components of UW solution that are essential to its success. Transplantation 1990; 49(6):1060-1066.




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