2013, Number 2
Arch Med Urg Mex 2013; 5 (2)
Methemoglobinemia induced by dapsone intake for suicide attempt purposes. A propos of a case
Nares TMÁ, Arredondo AJM, Ferrari GS, Sánchez VMC
Language: Spanish
References: 9
Page: 85-88
PDF size: 174.60 Kb.
ABSTRACT
Dapsone is a commonly prescribed leprostatic agent for the treatment of patients with leprosy, malaria, and a variety of skin diseases. Methemoglobinemia, a potentially life threatening when the oxygen carrying capacity of blood in the body tissues is reduced, is a known adverse effect of dapsone use. We report a case of dapsone induced Methemoglobinemia observed in the Emergency Service of Hospital General, Centro Médico Nacional la Raza, in a patient with vitiligo treated with dapsone and taking this for purposes of attempting suicide. The pathophysiological mechanisms, diagnosis, and treatment of dapsone-induced methemoglobinemia will be discussed.REFERENCES
Mansouri A, Lurie AA. Concise review: methemoglobinemia. Am J Hematology. 1993; 42: 7-12. Cuadro III. Comparación de la gasometría al ingreso, 48 horas y 5 días posterior al tratamiento médico. Ingreso 48 horas posteriores. 5 días posteriores. pH 7.30 7.40 7.38 P02 130 mmHg 80 mmHg 78 mmHg PC02 34 mmHg 32 mmHg 31 mmHg HC03 16 21 20 SAT % 89% 94% 93% Lactato 1.8 0.6 0.8 Metahemoglobinemia % 19.4 4.5 0.8