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Academia Mexicana de Neurología, A.C.

2013, Number 4

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Rev Mex Neuroci 2013; 14 (4)

Current status of modifying therapies in Alzheimer’s disease

Carrillo-Mora P, Mena-Barranco FJ, Navarrete-Báez H

Language: Spanish
References: 101
Page: 201-214
PDF size: 257.20 Kb.


ABSTRACT

All epidemiological estimates worldwide agree that in the coming decades it is expected a significant increase in Alzheimer’s disease (AD) cases. For this reason, there are globally unprecedented research efforts in both basic and clinical scope in the development of new therapies for AD that possess not only a symptomatic effect but actually modify significantly the course of disease (disease modifying treatments). Currently an amazing variety of therapeutic targets are being explored (some of them even already in clinical field), all based on the modification of one of the pathophysiological factors involved in AD: inhibitors and modulators of gamma secretase, alpha secretase activators, active and passive immunotherapy against Aβ and tau, aggregation inhibitors of Aβ and tau, phosphorylation tau inhibitors, antioxidants, anti-inflammatory, statins, gene therapy, and other factors. In this article we review the current status about the disease-modifying therapies in AD by therapeutic target. Unfortunately, current results of the vast majority of clinical studies have been negative for two main reasons: the severity of side effects and the lack of significant efficacy or both. Currently developing drugs in experimental studies have shown very promising effects but we should wait to see their clinical effects and long-term safety.


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