Cedano DA, Martínez GS, Torres BO, Zúñiga GG, Trujillo HB

Language: Spanish
References: 11
Page: 21-26
PDF size: 193.86 Kb.

ABSTRACT

The massive increases in world population, industrial development and urbanization have led strong environmental toxicological effects. Therefore it is important to identify particularly the compounds that cause damage chromosomal level. The objective was to evaluate the pig as bioindicators micronucleogénicos agents by the micronucleus test. 40 piglets were used which were divided into 4 lots: control lot 5 mg, 10 mg lot, and 20 mg of cyclophosphamide lot. , using this compound as a micronucleogénico inducing agent. Results were analyzed by the statistical tests of Friedman and Wilcoxon (P ‹0.05). Micronucleated polychromatic erythrocytes showed a significant statistical difference in lots 5 mg and 10 mg. In treatment 20 mg there is no significant difference. In the analysis of micronucleated erythrocytes, no significant difference was found. According to the results, we conclude that in piglets micronucleated polychromatic erythrocytes increased significantly at doses of 5 and 10 mg / kg of cyclophosphamide. At doses of 10 and 20 mg / kg of cyclophosphamide, piglets have cytotoxic effects in their myeloid system.

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