2013, Number 3
Use of lysed platelets in osteoarthritis of the knee
Language: Spanish
References: 23
Page: 374-386
PDF size: 350.69 Kb.
ABSTRACT
Introduction: Osteoarthritis is the most common joint ailment. Its treatments vary from conservative procedures to surgery, passing through joint injections and lately the use of plasma enriched in platelets.Objective: describe the clinical evolution of 20 patients with knee osteoarthritis who received joint injection of lysed platelets.
Material and Methods: we did a prospective longitudinal study with a 20 patient sample, referred with kneeosteoarthritis to the service of Orthopedics of the «Dr. Enrique Cabrera» University Hospital, provided they meet the inclusion requirements. Autologous lysed platelets were injected and a clinical follow up using variables such as pain, joint mobility, muscular strength and functional scale. A database was filled for statistical processing. It were calculated statistical measures.
Results: out of the 20 patients 14 were male and 6 female, age 39 to 81. 35 knees were injected. There was a trend to decrease of pain in 15 patients and gain of muscular strength in the injected cases. Regarding evolution of the physical activities, the tendency was improvement from very severe and severe to slight or none.
Conclusions: the improvement of pain, joint recovery and functional scale in the vast majority of the treated patients supports the mediation of platelet factors in the immediate anti-inflammatory action and its regenerative potential.
REFERENCES
Fernández-Delgado N, Hernández-Ramírez P, Forrellat-Barrios Mariela. Espectro funcional de las plaquetas: de la hemostasia a la medicina regenerativa. Rev Cubana Hematol Inmunol Hemoter [revista en la Internet]. 2012 sep. [Citado 2013 feb 22]; 28(3): 200-216. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-02892012000300002&lng=es
Collazo Álvarez H, Collazo Marin SY, Boada NM. Factores de crecimiento plaquetarios en lesiones traumáticas óseas y pseudotumorales. Rev Cubana Hematol Inmunol Hemoter. 2009;25 (1): Supl. A1. Resúmenes Orales Hematología. Resumen 3-3-21. Disponible en: http://bvs.sld.cu/revistas/hih/vol25-4-09/hih 02409.htm
García San Román FJ, Calcerrada Díaz-Santos N. Grupo de Trabajo de la guía de práctica clínica del manejo del paciente con artrosis de rodilla en Atención Primaria. Guía de Práctica Clínica del manejo del paciente con artrosis de rodilla en Atención Primaria. Madrid: Unidad de Evaluación de Tecnologías Sanitarias (UETS), Área de Investigación y Estudios Sanitarios. Agencia Laín Entralgo; Septiembre 2006.
Bravo Acosta T, Téllez Díaz Z, Hernández Tápanes S, Pedroso Morales I, Fernández Cuesta JI, López Pérez YM. Utilidad de un programa de rehabilitación para el mejoramiento de la calidad de vida en adultos mayores con gonartrosis. [revista en Internet] [revisado 5 marzo 2013]. Disponible en: http://bvs.sld.cu/revistas/mfr/vol_3_1_11/mfr06111.htm
Prado García OE, Arango García G, Moré Lozano R, Rey Valdivia N, López Díaz H. Osteotomía valguizante de tibia en el tratamiento de la gonartrosis. Rev Cubana Ortop Traumatol [revista en la Internet]. 2009 jun. [Citado 2013 feb 22]; 23(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-215X2009000100002&lng=es
Orozco Delclós L. Soler Rich R. Artrosis y lesiones del cartílago articular, tratamientos actuales y perspectivas de nuevas terapias. [Artículo en internet] [citado 2009 nov 16]. Disponible en: http://www.google.com.cu/search?hl=es &q=ARTROSIS+y+LESIONES+DEL+CART%C3%8DLAGO+ARTICULAR+tratamientos+actuales+y+perspectivas+de+nuevas+terapias &btnG=Buscar&aq=f&aqi=&aql=&oq=&gs_rfai