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2013, Number 3

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Revista Habanera de Ciencias Médicas 2013; 12 (3)

Immune status in children with chronic nonspecific diarrhea

Deyanira La Rosa Hernández, Elsa García Bacallao, Héctor Vega-Sánchez, Sacha Lazo-del Vallín, Ángela Elvires Gutiérrez, María Del Pilar Escobar Capote, Niurka Sánchez-Castañeda, Soamy Montesinos Goicolea, Emigdio León Toirac, Enrique J Gómez Cabeza

Language: Spanish
References: 23
Page: 354-363
PDF size: 210.13 Kb.


ABSTRACT

Introduction: chronic nonspecific diarrhea (CID) in childhood is frequent complaint, has not yet been able to determine the origin of this disease, and is invoked several theories that attempt to explain its pathophysiology based on associated immunological disorders.
Objective: to characterize the immune status of children with DCI.
Materials and Methods: we carried out a cross-sectional study of 36 children less than 6 years diagnosed with chronic nonspecific diarrhea treated at the Institute of Gastroenterology in the period March to December 2012. An All patients underwent complete blood count, determination of serum iron, total immunoglobulin dose and thymus´s ultrasound. For statistical analysis, parametric tests were used and differences were considered significant at p ‹0.05.
Results: the abandonment of exclusive breastfeeding before 6month and low serum immunoglobulin A (IgA) levels had a high frequency in our study. No association was found between cessation of breastfeeding before 6 months, thymic hypoplasia and low serum IgA levels.
Conclusions: most children with chronic nonspecific diarrhea have compromised their immune status. The main immune disorders are the thymic hypoplasia and low serum IgA levels.


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