2013, Number 3
<< Back Next >>
Revista Habanera de Ciencias Médicas 2013; 12 (3)
Motility factors at Barrett's Esophagus, according different endoscopic presentation
Anido EV, Cathcart RF, Brizuelas QR, García JE, Díaz DZ, Morera PM
Language: Spanish
References: 26
Page: 343-353
PDF size: 82.96 Kb.
ABSTRACT
Background: Barrett's esophagus is considered one of the most severe complications of gastroesophageal reflux disease, because its association with esophageal adenocarcinoma. Although motility studies show significant abnormalities at the antireflux barrier, not all patients show the same affectations.
Aims: by conventional esophageal manometry to define the characteristics of motility factors at antireflux barrier and esophageal motor disorders, in patients with Barrett, according to different endoscopic presentations.
Material and Methods: esophageal manometry was performed to a group of patients with Barrett, histologically confirmed. Characteristics of the antireflux barrier and esophageal body peristalsis were recorded. There were applied statistical techniques for the association between variables (multiple correlation and regression).
Results: predominance of patients with short segment, 61.3% male and a mean age of 47.7 years. Patients with long segment were lower resting pressure of the lower esophageal sphincter and larger hiatal hernias, while in patients with short segment, instability prevailed. Severe motor disorders predominated, with over 30% of failures of responses, but they were more important in patients with short-segment Barrett.
Conclusions: Tthere were differences in motility patterns between the group of patients with short-segment and long segment Barrett Esophagus.
REFERENCES
Sharma P. Clinical practice. Barrett´s esophagus. N Engl J Med. 2009;361(26):2548-56.
Matsuzaki J, Suzuki H, Asakura K, Saito Y, Hirata K, Takebayashi T, et al. Etiological difference between ultrashort and short segment Barrett´s esophagus. J Gastroenterol. 2011 Mar;46(3):332-8.
Ciriza-de-los Rios. Barrett´s esophagus-a review. Rev Esp Enf Dig. 2010;102(4):257-69.
Rubesntein JH. Shedaling some light on the etiology of adenocarcinoms of the esophagus and gastric cardias. Am J Gastroenterol. 2012 Dec;107(12):1814-6.
De Jonge PJF, van Blankenstein M, Looma CWN, Casparie MK, Meijer GA, Kuipers EJ. Risk of malignant progression in patients with Barrett´s oesophagus: a Dutch nationwide cohort study. Gut. 2010 Aug;59(8):1030-6.
Sharma P. Short segment Barrett´s esophagus: the need for standartization of the definition and endoscopic criteria. Am J Gastroenterol. 1998;93:1033-6.
Hahabzadeh B, Seetharam AB, Cook MC, Wanj S. Validation of the Prague C&M criteria for the endoscopic grading of Barrett's esophagus by gastreonterology trainees: a multicenter study. Gastrointest Endosc, 2012;75(2):236-41.
Fujiyama Y, Ishizuka I, Koyama S. Histochemical disgnosis of short segment Barrett's esophagus. Nihon Rinsho. 2005 Aug;63(8):1420-6.
Villanacci V, Bassotti G, Salemme M, Rossi E. Influence of genetics on tumoral patholohies: The example of the adenocarcinoma arising in Barrett´s esophagus. Rev Esp Enferm Dig. 2012 Dec;104(11):592-602.
Ang D, Blondeau K, Sifrim D, Tack J. The spectrum of motor function abnormalities in Gastroesophageal Reflux Disease and Barrett´s Esophagus. Digestion. 2009;79:158-168.
Savarino E, Zentino P, Frazzoni M, Cuoco DL, Pohl D, Dulbecco P, et al. Characteristics of gastro-esophageal reflux episodes in Barrett´s esophagus, erosive esophagitis and healthy volunteers. Neurogastroenterol Motil. 2010;22(10):1061-80.
Rajendra S, Kutty K, Karim N. Ethnic differences in the prevalence of endoscopic esophagitis and Barrett´s esophagus: the long and short of it all. Dig Dis Sci. 2004;49(2):237-42.
Anido V, Martínez R, Díaz-Canel Fernández O, García Menocal J, Pernía L, Díaz Z. Enfermedad por reflujo gastroesofágico: factores de motilidad. Endoscopia. 2008;20(2):120-8.
Anido V, Martínez R, Brizuela E, García Menocal J, Díaz Z, García E. Estudio por manometría esofágica de pacientes con enfermedad por reflujo gastroesofágico en Cuba. GEN. 2011;65(3):177-82.
Helman L, Nubes Biccas B, Lemme EMO, Novais P, Fittipaldi V. Esophageal manometry findings and degree of acid exposure in short and long Barrett's esophagus. Arq Gastroenterol. 2012 Jan-Mar;49(1):64-8.
Bresadola V, Adani GL, Londero F, Leo CA, Cherchi V, Lorenzin D, et al. Non-erosive and uncomplicated erosive reflux diseases: Difference in physiopathological and symptom pattern. World J Gastrointest Pathophysiol. 2011 June 15;2(3):42-8.
Iwakiri K, Sugiura T, Hayashi Y, Kotoyori M, Kawakami A, Makino H, et al. Esophageal motility in japanese patients with Barrett´s esophagus. J Gastroenterol. 2003;38:1036-41.
Thrift AP, Kendall BJ, Pandeya N, Vaughan TL, Whiteman DC, Study of Digestive Health. A clinical risk prediction model for Barrett's esophagus. Cancer Prev Res (Phila). 2012 Sep;5(9):1115-23.
Caum LC, Bizinelli SL, Pisani JCl, Amarantes HM, Ioshii SO, Carmes ER. Metaplasia especializada de esófago distal na doenca do refluxo gastroesofagico: prevalencia e aspectos clínico-epidemiologicos. Arq Gastroenterol. 2003;40(4):220-6.
Rosztoczy A, Izbeki F, Nemeth IB, Dulic S, Vadaszi K, Roka R, et al. Detailed esophageal function and morphological analysis shows high prevalence of gastroesophageal reflux disease and Barrett´s esophagus in patients with cervical inlet patch. Dis Esophagus. 2011;25(6):498-504.
Roman S, Pandolfino JE, Woodland P, Sifrim D, Lengliner J. Testing for gastroesophageal reflux in the 21st century. Ann NY Acad Sci. 2011 Sep;1232:358-64.
Frazzoni M, Manno M, DeMicheli E, Savarino V. Pathophysiological characteristics of the various forms of gastroesophageal reflux disease. Spectrum disease or distinct phenotypic presentantions? Dig Liver Dis. 2006;38(9):643-8.
Meneghetti AT, Tedesco P, Damani T, Patti MG. Esophageal mucosal damage may promote dysmotility and worsen esophageal acid exposure. J Gastrointest Surg. 2005;9(9):1313-7.
Iwakiri K, Tanaka Y, Kawami N, Sano H, Sakamoto S. Pathophysiology of gastroesophageal reflux disease: motility factors. Nihon Rinsho. 2007;65(5):829-35.
Shah AK, Wolfsen HC, Hemminger LL, Shag AA, DeVault KR. Changes in esophageal motility after porfimer sodium photodynamic therapy for Barrett´s dysplasia and mucosal carcinoma. Dis Esophagus. 2006;19(5):335-9.
Dickman R, Kim JL, Camargo L, Green SB, Sampliner RE, Garewal HS, Fass R. Correlation of gastroesophageal reflux disease symptoms characteristics with long-segment Barrett´s esophagus. Dis Esophagus. 2006;19(5):360-5.