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2013, Number 3

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Rev Cubana Plant Med 2013; 18 (3)

Achyrocline satureioides (Lam.) DC. (marcela) reduce el daño cerebral en la isquemia focal permanente en ratas

Rivera MF, Tejera CD, Abin CJA, Prunell SG, Martínez BM, Dajas MF

Language: English
References: 55
Page: 445-460
PDF size: 454.97 Kb.


ABSTRACT

Introduction: Achyrocline satureioides is a plant which has been widely used in popular medicine and experimental studies confirm its antioxidant and antiinflammatory effects, attributable to the presence of flavonoids, mainly quercetin.
Objectives: to evaluate the neuroprotective effects of a chronic oral preadministration to rats with an Achyrocline satureioides decoction (2 %).
Methods: for decoction, dried flowers of Achyrocline satureioides were used. The consumption of food and AS decoction/water of the rats was evaluated daily and weight gain weekly; quercetin content in the decoction and in the plasma of the rats was evaluated by high performance liquid chromatography. The cerebral damage was assessed with a tetrazolium salt (TTC) and a behavioral test was performed previously. Nissl staining and Fluoro-Jade histochemistry were used.
Results: the pre-treatment with Achyrocline satureioides in all groups reverted the functional deficit and, during 21 days, the infarction volume also decreased significantly. Nissl staining showed a higher percentage of preserved neuronal population and the Fluoro-Jade showed a decreased of the neurons in degeneration.
Conclusions: the quercetin levels in the decoction and plasma of rats could explain the preventive benefits of Achyrocline satureioides due to the antioxidant and antiinflammatory properties described for this flavonoid.


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