2013, Number 3
Value of ultrasonography of fetal thymus associated with structural and chromosomal alterations
Language: Spanish
References: 38
Page:
PDF size: 298.99 Kb.
ABSTRACT
The fetal thymus is a structure since it was displayed for the first time by ultrasound in 1989 has been gaining interest especially in the last decade due to its easy viewing with higher resolution equipment. This article aims to make available a review of the most recent assessment of fetal thymus with its measurement in echocardiographic view of the three vessels for those prenatal diagnosis specialists. Assessment of size by different methods either by measuring its transverse diameter, its perimeter and more recently the relationship thymic / thoracic, has demonstrated that its absence or hypoplasia is related to different fetal defects such as complex heart diseases , especially conotruncal and aortic arch, intrauterine growth delay, maternal preeclampsia, early sign of chorioamnionitis and prematurity, as well as those associated with 22q 11 deletion and in different trisomies such as 21, 18 and 13 and in predicting immune status after birth. Echocardiographic assessment of fetal thymus by measuring the three vessels, which is possible in 90% of cases, adds another valuable element to prenatal fetus examination.REFERENCES
Li L, Bahtiyar MO, Buhimschi CS, Zou L, Zhou QC, Copel JA. Assessment of the fetal thymus by two- and three-dimensional ultrasound during normal human gestation and in fetuses with congenital heart defects. Ultrasound Obstet Gynecol [Internet]. 2011 [citado 25 Oct 2012];37(4):[aprox. 6 p.]. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/uog.8853/pdf
Mohamed N, Eviston DP, Quinton AE, Benzie RJ, Kirby AC, Peek MJ, et al. Smaller fetal thymuses in pre-eclampsia: a prospective cross-sectional study. Ultrasound Obstet Gynecol [Internet]. 2011 [citado 25 Oct 2012];37(4):[aprox. 6 p.]. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/uog.8953/pdf
Chaoui R, Heling KS, Sarut Lopez A, Thiel G, Karl K. The thymicthoracic ratio in fetal heart defects: a simple way to identify fetuses at high risk for microdeletion 22q11. Ultrasound Obstet Gynecol [Internet]. 2011 [citado 25 Oct 2012];37(4):[aprox. 7 p.]. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/uog.8952/pdf
Cromi A, Ghezzi F, Raffaelli R, Bergamini V, Siesto G, Bolis P. Ultrasonographic measurement of thymus size in IUGR fetuses: a marker of the fetal immunoendocrine response to malnutrition. Ultrasound Obstet Gynecol [Internet]. 2009 [citado 25 Oct 2012];33(4):[aprox. 6 p.]. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/uog.6320/pdf
Yinon Y, Zalel Y, Weisz B, Mazaki-Tovi S, Sivan E, Schiff E, et al. Fetal thymus size as a predictor of chorioamnionitis in women with preterm premature rupture of membranes. Ultrasound Obstet Gynecol [Internet]. 2007 [citado 25 Oct 2012];29(6):[aprox. 5 p.]. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/uog.4022/pdf
Chaoui R. The examination of the normal fetal heart using two dimensional echocardiography. En: Yagel S, Gembruch U, Silverman N, editores. Fetal Cardiology: Embryology, Genetics, Physiology, Echocardiographic Evaluation, Diagnosis and Perinatal Management of Cardiac Diseases. New York: Informa Healthcare; 2008. p. 173-84.
Kyburz A, Bauersfeld U, Schinzel A, Riegel M, Hug M, Tomaske M, et al. The fate of children with microdeletion 22q11.2 syndrome and congenital heart defect: clinical course and cardiac outcome. Pediatr Cardiol [Internet]. 2008 [citado 25 Oct 2012];29:[aprox. 8 p.]. Disponible en: http://download.springer.com/static/pdf /888/art%253A10.1007%252Fs00246-007-9074 2.pdf?auth66=1353513312_56b0e7bc3be9d548edf48c3a283cfb6a&ext=.pdf
Gottlieb C, Li Z, Uzel G, Nussenblatt RB, Sen HN. Uveitis in DiGeorge syndrome: a case of autoimmune ocular inflammation in a patient with deletion 22q11.2. Ophthalmic Genet [Internet]. Mar 2010 [citado 25 Oct 2012];31(1):[aprox. 6 p.]. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009586/pdf/nihms258413.pdf
García Guevara C, Arencibia Faife J, Hernández Martínez Y, Crespo del Río A, García Morejón C, Savío Benavides A. Valor de la vista ecocardiográfica de los tres vasos en el pesquisaje de cardiopatías congénitas. Rev Cubana Genet Comunit [Internet]. 2010 [citado 25 Oct 2012];4(1):[aprox. 5 p.]. Disponible en: http://bvs.sld.cu/revistas/rcgc/v4n1/rgc020110.pdf
Kuvibidila S, Dardenne M, Savino W, Lepault F. Influence of iron-deficiency anemia on selected thymus functions in mice: thymulin biological activity, T-cell subsets, and thymocyte proliferation. Am J Clin Nutr [Internet]. 1990 [citado 25 Oct 2012];51(2):[aprox. 5 p.]. Disponible en: http://ajcn.nutrition.org/content/51 /2/228.full.pdf+html
Lang U, Baker RS, Khoury J, Clark KE. Effects of chronic reduction in uterine blood flow on fetal and placental growth in the sheep. Am J Physiol Regul Integr Comp Physiol [Internet]. 2000 [citado 25 Oct 2012];279(1):[aprox. 8 p.]. Disponible en: http://ajpregu.physiology.org/content/279/1/R53.full.pdf+html
El-Haieg DO, Zidan AA, El-Nemr MM. The relationship between sonographic fetal thymus size and the components of the systemic fetal inflammatory response syndrome in women with preterm prelabour rupture of membranes. BJOG [Internet]. 2000 [citado 25 Oct 2012];115(7):[aprox. 6 p.]. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2008.01715.x/pdf
Yinon Y, Zalel Y, Weisz B, Mazaki-Tovi S, Sivan E, Schiff E, et al. Fetal thymus size as a predictor of chorioamnionitis in women with preterm premature rupture of membranes. Ultrasound Obstet Gynecol [Internet]. 2007 [citado 25 Oct 2012];29(6):[aprox. 5 p.]. Disponible en: http://onlinelibrary.wiley.com/doi/10.1002/uog.4022/pdf
García Guevara C, Arencibia Faire J, Savío Benavides A, García Morejón C, Hernandez Y, Selman-Housein Sosa E. El pesquisaje prenatal sonográfico de las Cardiopatías Congénitas en Cuba. Rev Fed Arg Cardiol [Internet]. 2011 [citado 26 Mar 2013];40(3):[aprox. 8 p.]. Disponible en: http://www.fac.org.ar/1/revista/11v40n3/art_revis/revis01/guevara.php
Knutsen AP, Baker MW, Markert ML. Interpreting low T-cell receptor excision circles in newborns with DiGeorge anomaly: importance of assessing naive T-cell markers. J Allergy Clin Immunol [Internet]. Dec 2011 [citado 25 Oct 2012];128(6):[aprox. 2 p.]. Disponible en: http://download.journals.elsevierhealth.com/pdfs/journals/0091-6749 /PIIS0091674911013200.pdf
El-Haieg D, Zidan A, El-Nemr MM. The relationship between sonographic fetal thymus size and the components of the systemic fetal inflammatory response syndrome in women with preterm prelabour rupture of membranes. BJOG[Internet]. 2008 [citado 25 Oct 2012];115(7):[aprox. 6 p.]. Disponible en: http://onlinelibrary.wiley.com/doi/10.1111/j.1471-0528.2008.01715.x/pdf
Santner Nanan B, Peek MJ, Khanam R, Richarts L, Zhu E, Fazekas de St Groth B, et al. Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J Immunol[Internet]. 2009 [citado 25 Oct 2012];183(11):[aprox. 9 p.]. Disponible en: http://www.jimmunol.org/content/183/11/7023.full.pdf+html