medigraphic.com
ISSN 1561-3038 (Print)

2013, Number 2

<< Back Next >>

Rev Cubana Med Gen Integr 2013; 29 (2)

Environmental and genetic factors associated to paranoid schizophrenia in '28 de septiembre' health area

Núñez CAC, Frómeta MC, Hechavarria ED

Language: Spanish
References: 19
Page:
PDF size: 121.05 Kb.


ABSTRACT

Background: schizophrenia is an illnes that is marked by a variable expressiveness wihc suggests the existence of heterogeneus etiological factors and physiopathological processes. A hypothesis of gene-enviroment interaction is being considered as it main way of transmission.
Objetive: to determine the possible enviroment and genetic factors associated with the illness onset.
Methods: it carriedout an analytical-observational study of cases and controls on the area"28 de Septiembre" of Santiago de Cuba during the four month period of januaryapril of 2011.It included 40 patients with a diagnosis of paranoic schizophrenia recorded on the Psychiatrist service selected randomly stratified by sex, as well as 80 controls without this diagnosis to determine the possible enviromental and genetic factors that could have influenced on the appearance of the disease. Chi square test was applied and the relative opportunity (odds ratio) by trist interval.
Results: the civil status of single resulted significative at the appearing and three quarters of the cases studied presented a stressing went at the beginning of the disease. there was an asociation of the familiar antecedents of the affection in the cases. It was recorded a greater percentage affected persons in familiar of first degree in both groups difference that resulted to be more significative on the cases. It was also observed familiar addition of the affection more frequent on the cases than of the control.
Conclusions: it was demonstrated that there is an association of the family antecedents of the illness in all the cases. There was more percent of affected people in first degree families in both groups. Family illness aggregation was observed. Prenatal antecedents increase the risk and pre-morbid patterns since childhood were hightly significant.


REFERENCES

  1. Lantigua Cruz A. Introducción a la Genética Médica. La Habana. Editorial Ciencias Médicas; 2006.p. 204 -14.

  2. Guizar Vázquez JJ. Genética clínica. 3 ed. México: Editorial El Manual Moderno; 2003.p. 251-7.

  3. Martínez JA, Cuesta MJ, Peralta V. Etiología de la esquizofrenia: interacción genesambiente. Anales. 2005 [citado 23 diciembre 2010]; 20(2). Disponible en: http://www.cfnavarra.es/salud/anales/textos/vol20/n2/revis2a.html

  4. Freudenreich O, Weiss AP, Goff DC. Psychosis and schizophrenia. In: Stern TA, Rosenbaum JF, Fava M, Biederman J, Rauch SL, eds. Massachusetts General Hospital Comprehensive Clinical Psychiatry. Philadelphia: Mosby Elsevier; 2008.p. 28.

  5. Moreno Cidoncha E. Esquizofrenia. [citado 23 diciembre 2010]. Disponible en: http://www.psicologia-online.com/colaboradores/esther/esquizofrenia1/

  6. Sotolongo García Y, Oscar Menéndez JR, Valdés Mier MA, Campos Zamora M , Turró Mármol CM. Esquizofrenia, historia, impacto socioeconómico y atención primaria de salud. Rev Cubana Med Milit. 2004 [citado 23 diciembre 2010]; 33 (2). Disponible en: http://bvs.sld.cu/revistas/mil/vol33_2_04/mil08204.htm .

  7. Servat PM, Lehmann SY, Harari AK, Gajardo IL, Eva CP. Evaluación neuropsicológica en esquizofrenia. Rev. chil. neuro-psiquiatr. 2005 [citado 23 diciembre 2010]; 43 (3): 210-6. Disponible en: http://www.scielo.cl/scielo.php?pid=S0717- 92272005000300005&script=sci_arttext .

  8. Zoch CE. Esquizofrenia: Temas en psiquiatría. Capítulo VI. Hospital Nacional Psiquiátrico, Costa Rica [citado 23 diciembre 2010]. Disponible en: http://www.binasss.sa.cr/poblacion/esquizofrenia.htm .

  9. Martín García-Sánchez J C. Guía práctica clínica para el tratamiento de la esquizofrenia en centros de salud mental. Murcia. 2009 [citado 22 abril 2011]. p 11-2. Disponible en:http://www.guiasalud.es/GPC/GPC_443_Esquizofrenia_Murcia.pdf

  10. Martín Reyes M, Mendoza Quiñónez R, Díaz de Villalvilla T, Lombo P, Padrón Fernando A, Valdez Sosa M. Transmisión familiar de los síntomas positivos y negativos en la esquizofrenia familiar y esporádica. Actas Esp Psiquiatr. 2004; 32 (6): 353- 7.

  11. Harrison PJ. Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet. 2003 [citado 23 diciembre 2010]; 361 (9355):.417-9. Disponible en: http://es.wikipedia.org/wiki/Esquizofrenia

  12. Giugni M, Bordones Dl, Malave B, Grimón B, Monquet F, Joseph M. Herramienta de rehabilitación cognitiva en pacientes con esquizofrenia. Univ Cien Tecnol. 2009 [citado 19 de mayo de 2011]; 13(50):51-8. Disponible en:http://www.scielo.org.ve/pdf/uct/v13n50/art07.pdf .

  13. Owen M, O'Donovan M, Gotesman I. Psychiatric Genetics and Genomics. Oxford: University Press; 2003. p. 247-66.

  14. Moreno JL, Kurita M, Holloway T, Lopez J, Cadagan R, Martínez Sobrido L, et al. Maternal influenza viral infection causes schizophrenia-like alterations of 5-HTloin in A and mGluloin in receptors in the adult offspring. J Neurosci. 2011 [citado 23 diciembre 2010]; 31(5): 1863-72. Disponible en: http://portal.revistas.bvs.br/Transf.php?

  15. Mesa Castillo S, Gómez Barry H, González Núñez L. Presencia del virus en el Sistema Nervioso Central en fetos de madres esquizofrénicas: estudio con microscopia electrónica en el segundo trimestre de embarazo. Rev Hosp Psiquiátrico de la Habana. 2007 [citado 23 diciembre 2010]; 4(3). Disponible en: http://www.revistahph.sld.cu/hph0307/hph030207.html

  16. Brown AS. Infección prenatal como factor de riesgo para la esquizofrenia. Esquizofrenia Boletín 32; 2006: 200-2.

  17. Parra S, Crivillés S, Acebillo E, Soto JM, Santos T, Peláez R, et al. Esquizofrenia familiar y esporádica: un estudio clínico comparativo. Rev Psiquiatría Fac Med Barna. 2005; 32(4): 174-8.

  18. Schenkel LS, Spaulding WD, Dilillo D, Silverstein SM. Histories of childhood maltreatment in schizophrenia: relationships with premorbid functioning, symptomatology, and cognitive deficits. Schizophrenia Research.2005; 76 (2-3): 273- 86.

  19. Are child abuse and schizophrenia linked?. New scientist.2006 [citado 20 abril 2011]; 190(2556). Disponible en: http://www.newscientist.com/article/dn9351-arechild- abuse-and-schizophrenia-linked.html.




2020     |     www.medigraphic.com