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Órgano Oficial del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz

2013, Number 4

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Salud Mental 2013; 36 (4)

Melatonin effects on macro sleep architecture in Alzheimer’s disease patients

Cruz-Aguilar MA, Ramírez-Salado I, Cruz-Ulloa C, Benítez-King G

Language: Spanish
References: 39
Page: 271-277
PDF size: 247.14 Kb.


ABSTRACT

The objective of the present study was to evaluate the 5 mg. melatonin effects on the sleep macro-architecture in eight patients with middle to moderate Alzheimer´s disease (DTA). Using the polysomnographic technique (PSG), we made a simple-blind, non-randomized, controlled with placebo study. The PSG was carried out according to the following order: night 1: placebo administration; night 2 and 3: continues melatonin administration. In the first night with melatonin treatment, the sleep latency to the first episode of Stage 2, Delta and REM sleep, was significantly diminished as compared with placebo (≤.05). No significant difference in total time of each sleep stage and sleep efficiency was observed. Nevertheless, a tendency to diminish the total time of nocturnal wake and increase of the total sleep time in the second night with melatonin treatment was observed. We conclude that melatonin can improve sleep in patients with middle to moderate DTA.


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