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Academia Mexicana de Neurología, A.C.

2011, Number 5

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Rev Mex Neuroci 2011; 12 (5)

Auditory late responses: Mismatch negativity and P300 in two groups of elderly people

Barón-Herrera RA, Peñaloza-López YR, Flores-Rodríguez TB, Flores-Ávalos BG, García-Pedroza Felipe, Herrera-Rangel Aline B

Language: Spanish
References: 38
Page: 242-249
PDF size: 226.05 Kb.


ABSTRACT

Introduction: Electrophysiological studies of central auditory processing converge in two late potentials: Mismatch negativity (MMN) a pre-atentional response, and P 300 an attention-mediated response. Objective: To identify the variability of amplitude and latency of MMN and P300 responses between two groups of elderly people, in order to analyse changes related with age, attention and gender. Methods: A total of 60 subjects were studied, selecting 37 without identified neurological damage (8 women and 25 men) allocated into two groups: G1 (aged 60-69 years) and G2 (≥ 70 years). Audiometry, clinical evaluation for neurological risk, mini-mental state examination and ABR were performed. MMN and P300 amplitudes and latencies for leads C3, Cz, C4, F3, Fz and F4 were also assessed. Results of both groups were compared. Results: Differences between both groups were statistically significant in MMN amplitudes for leads C3 and C4 (p ‹ 0.05). Females showed important differences for P300 latencies in almost all leads, except FZ. Conclusion: Amplitude differences between the studied groups for MMN suggest the presence of compensatory phenomena mediated by voluntary attention implicit in P300. Latencies prolongations of P300 in the female gender could be related with the social context of a socially underprivileged population.


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