2012, Number 2
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Rev Mex Neuroci 2012; 13 (2)
Risk factors and outcome of patients with multiple sclerosis from the State of Michoacan, Mexico: A case-control study
Magaña-Zamora L, Chiquete E, Campos-González ID, Cantú-Leal R, Ibarra-Bravo O, Punzo-Bravo G, Rojas-Flores I
Language: Spanish
References: 36
Page: 78-85
PDF size: 238.60 Kb.
ABSTRACT
Introduction: Multiple sclerosis (MS) has not been
completely studied in different regions of Mexico. The
lack of information could be a barrier for the correct
identification and management of patients living with
MS.
Objective: To describe factors associated with MS
and its functional outcome in a Mexican population.
Material and methods: A case-control studied was
performed. From June 2008 to June 2010 cases with MS
were registered from different communities of the State
of Michoacan. An equal number of age-and-sex
paired subjects without known neurologic disease
comprised the control group. All were investigated for
risk factors.
Results: A total of 75 patients met MS
diagnostic criteria: mean age 3.6 years, female-tomale
ratio of 2:1, 77% from Morelia City, 81% with
relapsing-remitting MS. In univariate analysis, as
compared with controls, patients with MS were more
educated, and had a higher frequency of family
history for MS and of autoimmune diseases. However,
in the multivariate analysis only the family history of
autoimmune disease was significantly associated with
MS risk. The most frequent treatment for MS was
interferon beta (50%), combined immunosuppression
(36%), steroids alone (8%), and azathioprine (1%).
Nonetheless, 50% of MS patients declared using
complementary therapies. In a Cox proportional
hazards model, only the type of MS was a
prognosticator of a score in the Expanded Disability
Status Scale › 4, during a mean disease duration of 5
years (progressive forms of MS, RR: 7.29; IC del 95%:
2.51-21.19).
Conclusion: In this study the most
important epidemiological risk factor for MS was the
family history of autoimmunity. On the other hand, the
type of MS was the main determinant of functional
outcome.
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