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Rev Mex Med Repro 2013; 5.6 (4)
Language: Spanish
References: 20
Page: 171-177
PDF size: 1056.14 Kb.
ABSTRACT
Background: Obesity affects various aspects of health, including fertility. This condition has multiple causes: hormonal, seminal, mechanical, and genetic alterations, as well as lifestyle. Obese men express a hormonal profile with hyperestrogenic hypogonadotropic hypogonadism.
Objective: To determine the effect of IMC on the serum values of testosterone, estradiol, luteinizing hormone, sex hormone binding globulin (SHBG) and free androgen index (FAI) in male patients with infertility.
Patients and method: We conducted a cross-sectional study comparing 680 patients (mean age of 34 years). Hormonal profile and body mass index (BMI) were determined. Two hundred patients were included in several groups: normal weight, overweight and obese I; as well as 66 in the group of obesity ll and 14 in the obesity lll.
Results: There was a significant difference (
p‹0.05) with testosterone and SHBG normal-weight patients. There were notable differences in testosterone in all groups (normal: 17.68, 13.11/
p‹0.001 overweight, obesity I: 13.37/
p‹0.001, obesity II: 13.02/
p‹0.001, obesity III: 12.34/
p=0.002); SHBG in obesity (normal: 34.00, obesity I: 25.33/
p‹0.001, obesity II: 23.26/
p‹0.001, obesity III: 24.29/
p=0.03). Concentrations of estradiol (normal: 32.59) were very similar in patients with overweight (32.45/
p=0.922) but different in obese (obese I: 35.45/
p=0.52, obese II: 38.42/
p=0.005, obese III: 38.91/
p=0.120), although only a group reached statistical significance; free androgen index was different when comparing the normal weight (56.58) with overweight (41.54/
p≤0.001). Luteinizing hormone showed no difference.
Conclusions: There is an alteration in the hormonal profile dependent of hypothalamic-pituitary-cell of Leydig axis and BMI in men with normal weight similar to that referred by other authors.
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