medigraphic.com
Academia Mexicana de Neurología, A.C.

2010, Number 5

<< Back Next >>

Rev Mex Neuroci 2010; 11 (5)

Ewing’s sarcoma: Variety neuroepitelioma peripheral with clinical course of syndrome of medullary compression

Ferrer Y, Oliva SM, Muñoz CD, Hernández PA, Olmedo FO, Noguera HO, Moreau RN, Urdaneta LL

Language: Spanish
References: 41
Page: 368-372
PDF size: 160.25 Kb.


ABSTRACT

The objective of this report was to present a clinical case of Ewing’s sarcoma, neuroepithelioma peripheral variety, with clinical course of radicular and spinal cord associated with an intratumural abscess. It is a young man of 16 years-old, without important medical history. Clinical onset began a month before admission with pain located at dorsal region, of moderate to strong severity that gradually increases and exacerbated with Valsalva maneuver; also, he felt sensation of tingle in lower limbs. Two days before admission patient had lower limbs weakness urinary sphincter dysfunction. Neurological exam showed a conscious and oriented patient, with evidence of a sensitive level at T8, flaccid paraparesis 2/5 with right predominance, and areflexia. Magnetic resonance imaging was carried out with gadolinium, finding a lesion in dorsal paravertebral region. Biopsy of the surgical material revealed a tumor with round blue cells compatible with Ewing’s sarcoma, variety peripheral neuroepithelioma. In conclusion, even when the Ewing’s sarcoma is recognized as the second one neoplasia more frequent in pediatric age, the peripheral neuroepithelioma is an uncommon variant in clinical practice; its clinical course with spinal cord compression syndrome is exceptional, even more because its coexistence with abscess of the tumor.


REFERENCES

  1. Ewing J. Diffuse endothelioma of bone. Proc NY Pathol Soc 1921;17- 24.

  2. Horowitz M, Tsokos M, Delaney T. Ewing Sarcoma. CA Cancer J Clin 1992; 42: 1-4.

  3. Suarez-Antelo J, Rodríguez-García C, Montero-Martínez C, Verea- Hernando H. Sarcoma de Ewing pulmonar/tumor neuroectodérmico primitivo (PNET): aportación de un caso y revisión de la bibliografía. Arch Bronconeumol 2010; 46: 44-6.

  4. Souvirón R, Arenas O, Gil R, Pérez-Luengo E, Scola B. Tumor neuroectodérmico primitivo periférico/sarcoma de Ewing extraóseo del hueso temporal. Acta Otorrinolaringol 2005; 56: 38-40.

  5. Burchill SA. Ewing’s sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities. K Clin Pathol 2003; 56: 96- 102.

  6. Huang HY, Illei P, Zhao Z, Mazumdar M, Huvos A, Healey J, et al. Ewing Sarcomas With p53 Mutation or p16/p14ARF Homozygous Deletion: A Highly Lethal Subset Associated with Poor Chemoresponse. J Clin Oncol 2005; 3: 548-58.

  7. Mackintosh C, Madoz-Gúrpide J, Ordóñez JL, Osuna D, Herrero-Martín D. The molecular pathogenesis of Ewing’s sarcoma. Cancer Biol Ther 2010; 9: 655-67.

  8. Yoon L, Do Hoon K, Jong C, Kwang Ho I, Yu Whan O, Kyung C, Yong R. Primary Pulmonary Ewing’s Sarcoma/Primitive Neuroectodermal Tumor in a 67-year-old Man. J Korean Med Sci 2007; 22: 159-163.

  9. Radoje C, Nikica M, Marjan M, Slavko M, Dushan H, Atkinson E, Latincic S. Perigastric extraskeletal Ewing´s sarcoma: A case report. World J Gastroenterol 2009; 15: 245-7.

  10. Lakhdar F, Gana R, Laghmari M, Moufid F, Maaqili R, Bellakhdar F. Infected cervical epidural Ewing’s sarcoma (case report). J Neuororadiol 2008; 35: 51-5.

  11. Mut-Pons R, Gómez J, Ramírez-Latorre O, Vallcanera-Calatayud A. Manifestaciones radiológicas infrecuentes del sarcoma de Ewing en la infancia. Radiología 2009; 51: 63-70.

  12. Gosau M, Baumhoer D, Ihrler S, Kleinheinz J, Driemel O. Ewing sarcoma of the mandible mimicking an odontogenic abscess a case report. Head Face Med 2008; 4: 24.

  13. Yeop K, Seung-Koo L, Dong Joon K, Jinna K, Kyu-Sung L, Woohee J, Dong K. Intracranial Dural Metastasis of Ewing’s Sarcoma: a Case Report. Korean J Radiol 2008; 9: 76-9.

  14. Pekala JS, Gururangan S, Provenzale JM, Mukundan S. Central nervous system extraosseous Ewing sarcoma: radiologic manifestations of this newly defined pathologic entity. Am J Neuroradiol 2006; 27: 580-3.

  15. Dibendu B, Behnam S, Ramesh B, Kamarul J, Sainsbury R. Primitive Neuroectodermal Tumour (PNET) in subcutaneous abdominal wall: a case Report. International Seminars in Surgical Oncology 2009; 6: 10.

  16. Tamer C, Oksuz H, Hakverdi S, Karazincir S, Balci A, Yaldiz M. Primary peripheral primitive neuroectodermal tumor of the orbit. Can J Opthalmol 2007; 42: 138-40.

  17. Sun G, Li Z, Wang C. Peripheral neuroectodermal tumor of the maxilla. Br J Oral Maxillofac Surg 2007; 45: 226-7.

  18. Quinlan JF, Healy CF, Rotston D, Murray P. PNET of the hallux. Ir Med J 2004; 97: 118.

  19. Jayakumar S, Jatavalabulla S, Miller IM. Peripheral neuroectodermal tumor of the hand in an adult. J Hand Surg Eur 2007; 32: 460-8.

  20. Pauwels P, Ambrose P, Hattinger C, Lammens M, Dal Cin P, Ribot J, et al. Peripheral primitive neuroectodermal tumor of the cervix. Virchows Arch 2000; 436: 68-73.

  21. McCluggage WG, Sumathi VP, Nucci MR, Hirsch M, Dal Cin P, Wells M, et al. Ewing family of tumors involving the vulva and vagina: report of a series of four cases. J Clin Pathol 2007; 60: 674-80.

  22. Alvarez-Laso C, Azcano E, Gonzalez J, Gonzalez-Pinto I. Primitive neuroectodermal tumour of the retroperitoneum. Clin Transl Oncol 2008; 10: 380-2.

  23. Omers GR, Shago M, Zielenska M, Chan HS, Hgan BY. Primary subcutaneous primitive neuroectodermal tumor with aggressive behavior and an unusual karyotype: case report. Pediatr Dev Pathol 2004; 7: 538-45.

  24. Rosenburg AE. Bones, Joints and Soft Tissue Tumors. In: Kumar V, Abbas A, Fausto N (Eds.). Robbins and Cotran Pathological Basis of Disease. 2005; 1301-2.

  25. Businger A, Zettl A, Sonnet S, Ruszat R, Von M. Primitive neuroectodermal tumor of the kidney in an adult: a case report. Cases J 2009; 2: 6791.

  26. Lozano S, Martínez Tirado O. Sarcoma de Ewing: nuevas aproximaciones terapéuticas y búsqueda de dianas biológicas del oncogén EWS/ FLI-1. Universidad Autónoma de Barcelona, p. 24-72.

  27. Paulussen M, Bielack S, Jürgens H, Casali PG. Ewing’s sarcoma of the bone: Clinical Recommendations for diagnosis, treatment and followup, on behalf of the Guidelines Working Group. Annals of Oncology 2009; 28: 140-2.

  28. Siden H. The boy who refused an IV: a case report of subcutaneous clodronate for bone pain in a child with Ewing Sarcoma. J Med Case Reports 2007; 1: 7.

  29. Hawkins DS, Schuetze SM, Butrynski JE, Rajendran JG, Vernon ChB, Conrad EU 3rd, Eary JF. [18F] Fluorodeoxyglucose Positron Emission Tomography Predicts Outcome for Ewing Sarcoma Family of Tumors. J Clin Oncol 2005; 23: 8828-34.

  30. Maldonado MS, Muñoz A, Orejas L. Síndrome de comprensión medular aguda en el sarcoma de Ewing. Rev Esp Pediatr 2004; 60: 124-6.

  31. Choy E, Subba R. Digumarthy, Koplin S. Case 36-2009-A 23-Year-Old Man with Cough, Hoarseness, and Abnormalities on Chest Imaging. Case records of Massachusetts General Hospital. New E J Med 2009; 361: 2080-7.

  32. Sirrampalam SB, Chuah K. Primitive neuroectodermal tumors of the uterus: a case report with cytological correlation and review of literature. Pathology 2002; 34: 455-61.

  33. Gradoni P, Giordano D, Oretti G, Fantoni M, Ferri T. The role of surgery in children with head and neck rhabdomyosarcoma and Ewing’s sarcoma. Surg Oncol 2010. Feb 23. [Epub ahead of print].

  34. Su-Young K, Tsokos M, Helman LJ. Dilemmas Associated with Congenital Ewing Sarcoma Family Tumors. J Pediatr Hematol Oncol 2008; 30: 4-7.

  35. Yock T, Krailo M, Fryer C, Donaldson S, Miser J, Zhengjia C, et al. Ewing Sarcoma: Analysis from INT-0091, a report from the Children’s Oncology Group. J Clin Oncol 2006; 24: 3838-43.

  36. Scurr M, Hudson I. How to Treat the Ewing’s Family of Sarcomas in Adult Patients. The Oncologist 2006; 11: 65-72.

  37. Leavey P, Mascarenhas L, Marina N, Chen Z, Krailo M, Miser J, et al. Prognostic Factors for Patients with Ewing sarcoma (EWS) at First Recurrence Following Multimodality Therapy: A Report from the Children´s Oncology Group. Pediatric Blood Cancer 2008; 5: 334-8.

  38. Balamuth NJ, Womer RB. Ewing’s sarcoma. Lancet Oncol 2010; 11: 184-92.

  39. Espinosa E, Baron G, Juárez A, Castañón C, Linares P, Zamora A. El síndrome de compresión medular en el paciente oncológico que acude a urgencias. Emergencias: servicios de oncología médica, medicina interna y urgencias del hospital La Paz de Madrid 1997; (9): 6.

  40. Fariba N, Billups C, Liu T, Krasin M, Rodriguez-Galindo C. Second Cancers in Patients with the Ewing Sarcoma Family of Tumors. Eur J Cancer 2008; 44(7): 983-91.

  41. Lee Y, Kim HD, Lee H, Choi SJ, Ho In K, Whan OY, et al. Primary Pulmonary Ewing’s Sarcoma/Primitive Neuroectodermal Tumor in a 67- year-old Man. J Korean Med Sci 2007; 22 (Suppl.): S159-63.




2020     |     www.medigraphic.com