medigraphic.com
Academia Mexicana de Neurología, A.C.

2009, Number 5

<< Back Next >>

Rev Mex Neuroci 2009; 10 (5)

CD24v polymorphism associated with clinical progression of multiple sclerosis in a patient group Centro Medico Nacional 20 de Noviembre, ISSSTE

Dircio DV, Plascencia-Álvarez N, Chima GMC, Quiñones AS, González GRI, Núñez OL

Language: Spanish
References: 26
Page: 344-359
PDF size: 62.53 Kb.


ABSTRACT

Introduction: Multiple sclerosis (MS) is the most frequent demyelinating disease of central nervous system, in which previous reports found an association between the polymorphisms of CD24 and the progression of the disease. Objectives: To identify the polymorphism of CD24 in MS patients and their controls; to get the allelic frequency of CD24v polymorphism in patients with MS and controls; to associate the different CD24v genotypes with the clinical evolution of patients with MS. Material and methods: Transversal, opened study, with 50 subjects and 50 controls between 18 and 65 years old. We use PCR and restriction fragment long polimorfism (RFLPs) techniques for CD24v polymorphism determination. We compared the results using the Chi square test. Results: We found the CD24v polymorphism in 4% of homocygotic alleles. We did not find any association between the presence of the polymorphism and the progression of MS. Conclusion: It is necessary a bigger sample of subjects with MS to confirm or not the presence of CD24 protein mutation in Mexican people with MS.


REFERENCES

  1. Montalvan J, et al. Enfermedades desmielinizantes. 14a. Ed. En: Farreras R (ed.). Medicina Interna. Edit. Harcourt, 2002. cap 12. p. 845-853

  2. Kurtzke JK. Epidemiology of multiple sclerosis. In: Koetsier (ed.). Demyelinating Diseases. Ed. J.C.; l995, p. 259.

  3. Corona T, Rodríguez JL. Multiple sclerosis in Mexico: epidemiology and clinical findings in the Nacional Institute of Neurology and Neurosurgery. Mexico. Neurology 1996; 11: 170-3.

  4. Porras BM, Núñez OL, Plascencia N, Quiñones S. Esclerosis múltiple. Rev Mex Neuroci 2007; 8(1): 58-66.

  5. García-Pedroza F. Neuroepidemiología de la Esclerosis múltiple. En: Núñez Orozco L (Ed). El manejo integral de la esclerosis múltiple, 1ª. Ed, México. Edit. Prado. 2003. p. 7-18.

  6. Wang L, et al. A Dinucleotide Deletion in CD24 confers protection against autoimmune diseases. Plos Genetics 2007; 4(3): 508-17.

  7. Poser Cm, Paty dw, Scheimberg l, Mcdonald Wl, Davis Fa, Ebers Gc, et al. New diagnostic criteria for Multiple Sclerosis: guidelines for research protocols. Ann Neurol 1983; 13: 227-31.

  8. Investigación para la salud. 8a. Ed. En: Ley General de Salud de los Estados Unidos Mexicanos. México: Ed. Porrúa; 1994, p. 40-3.

  9. Recommendations guiding physicians in biomedical research involving human subjects. World Medical Association declaration of Helsinki 1999; 42(6): 635-97.

  10. Declaración internacional sobre los datos genéticos humanos. Octubre 2003. http:// www.unesco.org.

  11. Polman, et al. Diagnostic Criteria for Multiple Sclerosis: Revisions to the McDonald Criteria. Annals of Neurology 2005; 58: 840-6.

  12. Kurtzke JF. Rating neurological impairment in Multiple Sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983; 33: 1444-52.

  13. Rizvi Sa, Ngius Ma. Current approved options or treating patients with Multiple Sclerosis. Neurology 2004; 63(Suppl. 6): S8-S14.

  14. Noseworthy JH. Progress in determiing the causes and treatment of Multiple Sclerosis. Nature 1999; 399(6738): a40-7.

  15. Johnson RT. Viral aspects of multiple sclerosis. In: Demyelinating diseases. Edit. J.C. Koitser; 1995, p. 319-21.

  16. Martin C, et al. Seven human herpes viruses by Polymerase Chain Reaction in CSF and blood from patients with Multiple Sclerosis and optic neuritis. Acta Neurol Scand 1997; 95: 280-3.

  17. Kelly Ma, Jacobs Kh, Penny Ma, Mijovic Ch, Nigthingales Barnett Ah, Francis Da. An investigation of HLA-encoded genetic susceptibility to Multiple Sclerosis in subjects of Asian Indian and Afro-Caribbean ethnic origin. Tissue antigens 1995; 45: 197.

  18. Springer T. Monoclonal xenogeneic antibodies to murine cell surface antigens. Eur J Immunol 1978; 8: 539-51.

  19. Rougon G, et al. The murine heat-stable antigen: a differentiation expressed in both the hematolymphoid and neural cell lineages. Eur J Immunol 1991; 21: 1397-402.

  20. Liu Y, Zheng P. CD24: a Genetic Checkpoint in T Cell Homeostasis and Autoinmune Diseases. Trends in Immunology 2007; 7(28): 315-20.

  21. Bai XF, et al. CD24 Controls Expansion and Persistence of Autoreactive T cells in the Central Nervus System during experimental autoimmune encephalomyelitis. J Exp Med 2004; 200: 447-58.

  22. Kleene, R, et al. The neural recognition molecule l1 is a sialic acidbinding lectin for CD24, wich induces promotion and inhibition of neurite outgrown. J Biol Chem 2001; 276: 21656-63.

  23. Hahne M, et al. The heat-stable antigen can alter very late antigen 4- mediated adhesion. J Exp Med 1994; 179: 1391-5.

  24. Zhou Q, et al. Regulation of the stability of the heat-stable antigen MRA by interplay between two novel cis-elements in the 3’untraslated region. Mol Cell Biol 1998; 18: 815-26.

  25. Zhou Q, et al. CD24 is a genetic modifier for risk and progression of Multiple Sclerosis. Proc Natl Acad Sci USA 2003; 25(100): 15041-6.

  26. Hafler D. Multiple sclerosis. The Journal of Clinical Investigation 2004; 6(113): 788-95.




2020     |     www.medigraphic.com